Recombinant Human IL-17 RA/IL-17 R Fc Chimera Protein, CF

Catalog # Availability Size / Price Qty
177-IR-100
Product Details
Citations (2)
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Recombinant Human IL-17 RA/IL-17 R Fc Chimera Protein, CF Summary

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit IL-17-induced IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.03‑0.1 µg/mL in the presence of 10 ng/mL recombinant human IL‑17.
Source
Mouse myeloma cell line, NS0-derived human IL-17 RA/IL-17 R protein
Human IL-17 RA/IL-17 R
(Leu33-Trp 320)
Accession # Q96F46
IEGRMD Human IgG1
(Pro100-Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Analysis
Leu33
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
60 kDa (monomer)
SDS-PAGE
100 kDa, reducing conditions

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Background: IL-17 RA/IL-17 R

Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22. Human IL‑17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy‑proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of human IL‑17 R is 69% identical to the mouse IL‑17 R. The signaling events of IL‑17 includes activation of NF‑ kappa B and JNK, and require TNF receptor‑associated factors 6 (TRAF6) in the signaling pathway.

References
  1. Yao, Z. et al. (1997) Cytokine 9:794.
  2. Schwander, R. et al. (2000) J. Exp. Med. 191:1233.
Long Name
Interleukin 17 Receptor
Entrez Gene IDs
23765 (Human); 16172 (Mouse); 312679 (Rat)
Alternate Names
CD217 antigen; CD217; Cdw217; CDw217interleukin 17 receptor; hIL-17R; IL-17 R; IL-17 RA; IL-17 receptor A; IL17RA; IL-17RA; IL-17RAMGC10262; IL17Rinterleukin-17 receptor A; interleukin 17 receptor A

Citations for Recombinant Human IL-17 RA/IL-17 R Fc Chimera Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
    Sci Rep, 2016;6(0):26071.
    Species: Human
    Sample Types: Whole Cells
    Applications: Surface Plasmon Resonance
  2. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
    Sci Rep, 2016;6(0):30859.
    Species: Human
    Sample Types: Protein
    Applications: FRET

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Human IgG1 Antibody

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