Recombinant Human IL-17 RA/IL-17 R Fc Chimera Protein, CF
Recombinant Human IL-17 RA/IL-17 R Fc Chimera Protein, CF Summary
|Human IL-17 RA/IL-17 R
Accession # Q96F46
Background: IL-17 RA/IL-17 R
Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22. Human IL‑17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy‑proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of human IL‑17 R is 69% identical to the mouse IL‑17 R. The signaling events of IL‑17 includes activation of NF‑ kappa B and JNK, and require TNF receptor‑associated factors 6 (TRAF6) in the signaling pathway.
Citations for Recombinant Human IL-17 RA/IL-17 R Fc Chimera Protein, CF
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Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
Sci Rep, 2016;6(0):26071.
Sample Types: Whole Cells
Applications: Surface Plasmon Resonance
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Sci Rep, 2016;6(0):30859.
Sample Types: Protein
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