Recombinant Human IL-17 RA/IL-17 R Fc Chimera Protein, CF

  (2 citations)     
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Citations (2)
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  • Purity
    >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured by its ability to inhibit IL-17-induced IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.03‑0.1 µg/mL in the presence of 10 ng/mL recombinant human IL‑17.
  • Source
    Mouse myeloma cell line, NS0-derived human IL-17 RA/IL-17 R protein
    Human IL-17 RA/IL-17 R
    (Leu33-Trp 320)
    Accession # Q96F46
    IEGRMD Human IgG1
    (Pro100-Lys330)
    N-terminus C-terminus
  • Accession #
  • N-terminal Sequence
    Analysis
    Leu33
  • Structure / Form
    Disulfide-linked homodimer
  • Predicted Molecular Mass
    60 kDa (monomer)
  • SDS-PAGE
    100 kDa, reducing conditions
Product Datasheets

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177-IR
 
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
 
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
 
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
 
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
 
Background: IL-17 RA/IL-17 R

Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22. Human IL‑17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy‑proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of human IL‑17 R is 69% identical to the mouse IL‑17 R. The signaling events of IL‑17 includes activation of NF‑ kappa B and JNK, and require TNF receptor‑associated factors 6 (TRAF6) in the signaling pathway.

  • References:
    1. Yao, Z. et al. (1997) Cytokine 9:794.
    2. Schwander, R. et al. (2000) J. Exp. Med. 191:1233.
  • Long Name:
    Interleukin 17 Receptor
  • Entrez Gene IDs:
    23765 (Human); 16172 (Mouse); 312679 (Rat)
  • Alternate Names:
    CD217 antigen; CD217; Cdw217; CDw217interleukin 17 receptor; hIL-17R; IL-17 R; IL-17 RA; IL-17 receptor A; IL17RA; IL-17RA; IL-17RAMGC10262; IL17Rinterleukin-17 receptor A; interleukin 17 receptor A
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Species
Applications
Sample Type
  1. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
    Sci Rep, 2016;6(0):30859.
    Species: Human
    Sample Type: Protein
    Application: FRET
  2. Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
    Sci Rep, 2016;6(0):26071.
    Species: Human
    Sample Type: Whole Cells
    Application: Surface Plasmon Resonance

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Primary Antibodies
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Human IgG1 Antibody

WB , ELISA MAB9894  
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Human IgG1 Antibody

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Recombinant Proteins
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Recombinant Human IgG1 Fc Protein, CF

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Reconstitution Buffers
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Reconstitution Buffer 1 (PBS)

RB01
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