Recombinant Human LILRA4/CD85g/ILT7 Protein, CF Summary
Glu24-Asn446, with a C-terminal 6-His tag
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 100 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation (1). Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain (2). Alternative splicing generates an additional isoform that lacks the signal peptide and a portion of the first Ig-like domain. LILRA4 is expressed on plasmacytoid dendritic cells (pDC) but is down-regulated in response to TLR9 signaling (3-5). Antibody mediated crosslinking of LILRA4 on pDC inhibits the production of type I interferons following TLR7 or TLR9 stimulation (3, 4, 6). It also blocks the up-regulation of CCR7 but enhances the up-regulation of Integrin beta 7 on TLR7/9-stimulated pDC (6). LILRA4 associates with the ITAM-containing adaptor protein Fc epsilon RI gamma (3, 4, 6), and this complex binds to cell surface BST2/Tetherin which is expressed on monocytes, plasmacytoid and myeloid dendritic cells, B cells, and activated CD4+ and CD8+ T cells (5, 8). This interaction inhibits the TLR-induced pDC production of type I interferons, IL-6, and TNF-alpha (8).
- Thomas, R. et al. (2010) Clin. Rev. Allergy Immunol. 38:159.
- Young, N.T. et al. (2001) Immunogenetics 53:270.
- Cho, M. et al. (2008) Int. Immunol. 20:155.
- Cao, W. et al. (2006) J. Exp. Med. 203:1399.
- Tavano, B. et al. (2013) J. Immunol. 190:2622.
- Tsukamoto, N. et al. (2009) Clin. Cancer Res. 15:5733.
- Tavano, B. and A. Boasso (2014) PLoS ONE 9:e89414.
- Cao, W. et al. (2009) J. Exp. Med. 206:1603.
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