Recombinant Human/Mouse/Rat Activin A Protein, CF

(210 citations)   
  • Purity
    >95%, by SDS-PAGE with silver staining.
  • Endotoxin Level
    <0.01 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al. (1991) Method Enzymol. 198:340. The ED50 for this effect is 0.2-1.2 ng/mL.
    The specific activity of Recombinant Human/Mouse/Rat Activin A is approximately 1 IU/μg, which is calibrated against human Activin A WHO International Standard (NIBSC code: 91/626).
  • Source
    Chinese Hamster Ovary cell line, CHO-derived Gly311-Ser426
  • Accession #
  • N-terminal Sequence
    Analysis
    Gly311
  • Structure / Form
    Disulfide-linked homodimer
  • Predicted Molecular Mass
    13 kDa (monomer)
  • SDS-PAGE
    14 kDa, reducing conditions
    24 kDa, non-reducing conditions
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
338-AC/CF
 
338-AC
Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 100-500 µg/mL in sterile 4 mM HCl.
Reconstitution Reconstitute at 100-500 μg/mL in sterile 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC/CF) induces hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 is 0.2‑1.2 ng/mL.
1 μg/lane of Recombinant Human/Mouse/Rat Activin A was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 14 kDa and 24 kDa, respectively.
Recombinant Human/Mouse/Rat Activin A Promotes the Differentiation of Pluripotent Stem Cells into Endoderm.
BG01V human embryonic stem cells were differentiated into endoderm using media supplemented with Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC). Control cells were cultured in medium without recombinant Activin A. Differentiation into endoderm was confirmed by positive-staining for Claudin-6 (red) and Sox17 (green) using the Mouse Anti-Human Claudin-6 Monoclonal Antibody (Catalog # MAB3656) and the Goat Anti-Human Sox17 Polyclonal Antibody (Catalog # AF1924), respectively. BG01V human embryonic stem cells are licensed from ViaCyte, Inc.
Background: Activin A
Activin and Inhibin are members of the TGF-beta superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis (1‑7). Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfide-linked dimers of the bioactive proteins (8, 9). Activins are nonglycosylated homodimers or heterodimers of various beta subunits ( beta A, beta B, beta C, and beta E in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two beta A chains. The beta A subunit can also heterodimerize with a beta B or beta C subunit to form Activin AB and Activin AC, respectively (10). The 14 kDa mature human beta A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat beta A. Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK-4 (7, 11). Signaling through this receptor complex leads to Smad activation and regulation of activin-responsive gene transcription (7, 11). The bioactivity of Activin A is regulated by a variety of mechanisms (11). BAMBI, Betaglycan, and Cripto are cell‑associated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly (12‑14). The intracellular formation of Activin A can be prevented by the incorporation of the beta A subunit into Activin AC or Inhibin A (3, 10). And the bioavailability of Activin A is restricted by its incorporation into inactive complexes with alpha 2-Macroglobulin, Follistatin, and FLRG (15, 16).
  • References:
    1. Kumanov, P. et al. (2005) Reprod. Biomed. Online 10:786.
    2. Maeshima, A. et al. (2008) Endocr. J. 55:1.
    3. Rodgarkia-Dara, C. et al. (2006) Mutat. Res. 613:123.
    4. Werner, S. and C. Alzheimer (2006) Cytokine Growth Factor Rev. 17:157.
    5. Xu, P. and A.K. Hall (2006) Dev. Biol. 299:303.
    6. Shav-Tal, Y. and D. Zipori (2002) Stem Cells 20:493.
    7. Chen, Y.G. et al. (2006) Exp. Biol. Med. 231:534.
    8. Gray, A.M. and A.J. Mason (1990) Science 247:1328.
    9. Mason, A.J. et al. (1996) Mol. Endocrinol. 10:1055.
    10. Thompson, T.B. et al. (2004) Mol. Cell. Endocrinol. 225:9.
    11. Harrison, C.A. et al. (2005) Trends Endocrinol. Metab. 16:73.
    12. Onichtchouk, D. et al. (1999) Nature 401:480.
    13. Gray, P.C. et al. (2002) Mol. Cell. Endocrinol. 188:254.
    14. Kelber, J.A. et al. (2008) J. Biol. Chem. 283:4490.
    15. Phillips, D.J. et al. (1997) J. Endocrinol. 155:65.
    16. Schneyer, A. et al. (2003) Endocrinology 144:1671.
  • Entrez Gene IDs:
    3624 (Human); 16323 (Mouse)
  • Alternate Names:
    Activin A; INHBA
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

210 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening
    Authors: ZQ He, BL Xia, YK Wang, J Li, GH Feng, LL Zhang, YH Li, HF Wan, TD Li, K Xu, XW Yuan, YF Li, XX Zhang, Y Zhang, L Wang, W Li, Q Zhou
    Cell Rep, 2017;20(9):2227-2237.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System
    Authors: K Low, LY Wong, M Maldonado, C Manjunath, CB Horner, M Perez, NV Myung, J Nam
    Stem Cell Reports, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  3. In Vitro Micropatterned Human Pluripotent Stem Cell Test (�P-hPST) for Morphometric-Based Teratogen Screening
    Authors: J Xing, Y Cao, Y Yu, H Li, Z Song, H Yu
    Sci Rep, 2017;7(1):8491.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  4. Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
    Authors: K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya
    J. Clin. Invest., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  5. Insulin-producing cells derived from 'induced pluripotent stem cells' of patients with fulminant type 1 diabetes: vulnerability to cytokine insults and increased expression of apoptosis-related genes
    Authors: Y Hosokawa, T Toyoda, K Fukui, MY Baden, M Funato, Y Kondo, T Sudo, H Iwahashi, M Kishida, C Okada, A Watanabe, I Asaka, K Osafune, A Imagawa, I Shimomura
    J Diabetes Investig, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  6. Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity
    Authors: S Merfeld-Cl, H Lu, X Wu, KL March, DO Traktuev
    J. Cell. Mol. Med., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  7. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells
    Authors: F Sampazioti, MC de Brito, I Geti, A Bertero, NR Hannan, L Vallier
    Nat Protoc, 2017;12(4):814-827.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  8. Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses
    Authors: S Tousa, M Semitekolo, I Morianos, A Banos, AI Trochoutso, TM Brodie, N Poulos, K Samitas, M Kapasa, D Konstantop, G Paraskevop, M Gaga, CM Hawrylowic, F Sallusto, G Xanthou
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  9. Supraphysiological levels of GDF11 induce striated muscle atrophy
    Authors: DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney
    EMBO Mol Med, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  10. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci
    Authors: EE Pashos, Y Park, X Wang, A Raghavan, W Yang, D Abbey, DT Peters, J Arbelaez, M Hernandez, N Kuperwasse, W Li, Z Lian, Y Liu, W Lv, SL Lytle-Gabb, DH Marchadier, P Rogov, J Shi, KJ Slovik, IM Stylianou, L Wang, R Yan, X Zhang, S Kathiresan, SA Duncan, TS Mikkelsen, EE Morrisey, DJ Rader, CD Brown, K Musunuru
    Cell Stem Cell, 2017;20(4):558-570.e10.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  11. The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGF? and Activin pathways
    Authors: M García, R Barrio, M García-Lav, AR Garcia-Ren, A Escudero, E Díaz-Rodrí, D Gorbenko D, A Fernández, YB de Rijke, E Vallespín, J Nevado, P Lapunzina, V Matre, PM Hinkle, AC Hokken-Koe, MP de Miguel, JM Cameselle-, M Nistal, CV Alvarez, JC Moreno
    Sci Rep, 2017;7(0):42937.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  12. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells
    Authors: C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat
    J. Biol. Chem., 2017;0(0):.
    Species: Sheep
    Sample Type: Whole Cells
    Application: Bioassay
  13. Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells
    Authors: X Zhang, H Cao, S Bai, W Huo, Y Ma
    Stem Cell Res, 2017;20(0):21-29.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  14. Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors
    Authors: G Valenti, HM Quinn, GJ Heynen, L Lan, JD Holland, R Vogel, A Wulf-Golde, W Birchmeier
    Cancer Res, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse
    Authors: B Ulmer, M Tingler, S Kurz, M Maerker, P Andre, D Mönch, M Campione, K Dei beta ler, M Lewandoski, T Thumberger, A Schweicker, A Fainsod, H Steinbei beta e, M Blum
    Sci Rep, 2017;7(0):43010.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  16. In�Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling
    Authors: K Yamamizu, M Iwasaki, H Takakubo, T Sakamoto, T Ikuno, M Miyoshi, T Kondo, Y Nakao, M Nakagawa, H Inoue, JK Yamashita
    Stem Cell Reports, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  17. Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells
    Authors: T Jiajie, Y Yanzhou, AC Hoi-Hung, C Zi-Jiang, C Wai-Yee
    Sci Rep, 2017;7(0):41304.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
    Authors: Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, L Huan, HS Tan, R Kanesvaran, H Yu, MH Tan
    Sci Rep, 2017;7(0):41238.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  19. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo
    Authors: S Stayte, P Rentsch, AR Tr”scher, M Bamberger, KM Li, B Vissel
    PLoS ONE, 2017;12(1):e0167211.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  20. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells
    Nat Protoc, 2017;12(1):195-207.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  21. Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells
    Nat Protoc, 2017;12(1):15-31.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  22. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
    Authors: N Cerdá-Este, H Naumann, S Ruzittu, N Mah, IM Pongrac, C Cozzitorto, A Hommel, MA Andrade-Na, E Bonifacio, FM Spagnoli
    Nat Commun, 2017;8(0):14127.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  23. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration
    Authors: JS Saini, B Corneo, JD Miller, TR Kiehl, Q Wang, NC Boles, TA Blenkinsop, JH Stern, S Temple
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  24. The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes
    Authors: N Merienne, G Vachey, L de Longpre, C Meunier, V Zimmer, G Perriard, M Canales, A Mathias, L Herrgott, T Beltramine, A Maulet, T Dequesne, C Pythoud, M Rey, L Pellerin, E Brouillet, AL Perrier, R du Pasquie, N Déglon
    Cell Rep, 2017;20(12):2980-2991.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  25. Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing
    Authors: M Crespo, E Vilar, SY Tsai, K Chang, S Amin, T Srinivasan, T Zhang, NH Pipalia, HJ Chen, M Witherspoo, M Gordillo, JZ Xiang, FR Maxfield, S Lipkin, T Evans, S Chen
    Nat. Med., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  26. Activin signaling is an essential component of the TGF-? induced pro-metastatic phenotype in colorectal cancer
    Authors: JJ Staudacher, J Bauer, A Jana, J Tian, T Carroll, G Mancinelli, Ö Özden, N Krett, G Guzman, D Kerr, P Grippo, B Jung
    Sci Rep, 2017;7(1):5569.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  27. Activin Receptor Type IIA (ACVR2A) Functions Directly in Osteoblasts as a Negative Regulator of Bone Mass
    Authors: BC Goh, V Singhal, AJ Herrera, RE Tomlinson, S Kim, MC Faugere, EL Germain-Le, TL Clemens, SJ Lee, DJ DiGirolamo
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  28. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes
    Authors: G Yücel, Z Zhao, I El-Battraw, H Lan, S Lang, X Li, F Buljubasic, WH Zimmermann, L Cyganek, J Utikal, U Ravens, T Wieland, M Borggrefe, XB Zhou, I Akin
    Sci Rep, 2017;7(1):2935.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  29. Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
    Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
    Sci Rep, 2017;7(1):2585.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  30. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations
    Authors: JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller
    Cell Stem Cell, 2017;21(2):179-194.e4.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  31. Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate
    Authors: AG Freire, A Waghray, F Soares-da-, TP Resende, DF Lee, CF Pereira, DS Nascimento, IR Lemischka, P Pinto-do-Ó
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer
    Authors: DD Seachrist, ST Sizemore, E Johnson, FW Abdul-Kari, KL Weber Bonk, RA Keri
    Breast Cancer Res., 2017;19(1):66.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  33. Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols
    Authors: D Jeziorowsk, V Fontaine, C Jouve, E Villard, S Dussaud, D Akbar, V Letang, P Cervello, JM Itier, MP Pruniaux, JS Hulot
    Int J Mol Sci, 2017;18(6):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  34. Differentiation of cardiomyocytes and generation of human engineered heart tissue
    Authors: K Breckwoldt, D Letuffe-Br, I Mannhardt, T Schulze, B Ulmer, T Werner, A Benzin, B Klampe, MC Reinsch, S Laufer, A Shibamiya, M Prondzynsk, G Mearini, D Schade, S Fuchs, C Neuber, E Krämer, U Saleem, ML Schulze, ML Rodriguez, T Eschenhage, A Hansen
    Nat Protoc, 2017;12(6):1177-1197.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  35. Direct comparison of distinct naive pluripotent states in human embryonic stem cells
    Authors: S Warrier, M Van der Je, G Duggal, L Tilleman, E Sutherland, J Taelman, M Popovic, S Lierman, S Chuva De S, A Van Soom, L Peelman, F Van Nieuwe, DIM De Coninck, B Menten, P Mestdagh, J Van de Som, D Deforce, P De Sutter, B Heindryckx
    Nat Commun, 2017;8(0):15055.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  36. Activin A more prominently regulates muscle mass in primates than does GDF8
    Authors: E Latres, J Mastaitis, W Fury, L Miloscio, J Trejos, J Pangilinan, H Okamoto, K Cavino, E Na, A Papatheodo, T Willer, Y Bai, J Hae Kim, A Rafique, S Jaspers, T Stitt, AJ Murphy, GD Yancopoulo, J Gromada
    Nat Commun, 2017;8(0):15153.
    Species: Human
    Sample Type: Recombinant Protein
    Application: Surface Plasmon Resonance
  37. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations
    Authors: Q Gu, J Wang, L Wang, ZX Liu, WW Zhu, YQ Tan, WF Han, J Wu, CJ Feng, JH Fang, L Liu, L Wang, W Li, XY Zhao, BY Hu, J Hao, Q Zhou
    Stem Cell Reports, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  38. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
    Authors: KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
    Nat Commun, 2017;8(1):331.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  39. A pluripotent stem cell-based model for post-implantation human amniotic sac development
    Authors: Y Shao, K Taniguchi, RF Townshend, T Miki, DL Gumucio, J Fu
    Nat Commun, 2017;8(1):208.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  40. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
    Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
    Cell Rep, 2017;20(7):1597-1608.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  41. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
    Authors: NG Kooreman, PE de Almeida, JP Stack, RV Nelakanti, S Diecke, NY Shao, RJ Swijnenbur, V Sanchez-Fr, E Matsa, C Liu, AJ Connolly, JF Hamming, PHA Quax, MA Brehm, DL Greiner, LD Shultz, JC Wu
    Cell Rep, 2017;20(8):1978-1990.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  42. BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5
    Authors: LK Bollum, K Huse, MP Oksvold, B Bai, VI Hilden, L Forfang, SO Yoon, S Wälchli, EB Smeland, JH Myklebust
    PLoS ONE, 2017;12(5):e0177188.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  43. Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes
    Stem Cells Transl Med, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  44. Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose
    PLoS ONE, 2016;11(9):e0163580.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells
    Stem Cell Res Ther, 2016;7(1):127.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  46. Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation
    Nat Commun, 2016;7(0):12603.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  47. Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells
    PLoS ONE, 2016;11(7):e0159246.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. Growth hormone is permissive for neoplastic colon growth
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  49. Activin A programs the differentiation of human TFH cells
    Nat Immunol, 2016;17(8):976-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia
    Authors: N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer
    Nat. Med., 2016;22(12):1421-1427.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  52. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling
    Stem Cell Res Ther, 2016;7(1):115.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  53. Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages
    EMBO Mol Med, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  54. Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling
    Authors: L Song, J Chen, G Peng, K Tang, N Jing
    J. Biol. Chem., 2016;291(29):15212-25.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  55. In�Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts
    Authors: S Kadota, L Pabon, H Reinecke, CE Murry
    Stem Cell Reports, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  56. Repressed SIRT1/PGC-1? pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration
    J Transl Med, 2016;14(1):344.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  57. Transient RUNX1 Expression during Early Mesendodermal Differentiation of�hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling
    Stem Cell Reports, 2016;7(5):884-896.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  58. Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-Versus-Host Disease in Mice
    Stem Cells Transl Med, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  59. Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells.
    Authors: Nagaoka M, Kobayashi M, Kawai C, Mallanna S, Duncan S
    PLoS ONE, 2015;10(8):e0136350.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  60. Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary.
    Authors: Wang Z, Niu W, Wang Y, Teng Z, Wen J, Xia G, Wang C
    PLoS ONE, 2015;10(6):e0129643.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  61. Alternative Routes to Induce Naive Pluripotency in Human Embryonic Stem Cells.
    Authors: Duggal G, Warrier S, Ghimire S, Broekaert D, Van der Jeught M, Lierman S, Deroo T, Peelman L, Van Soom A, Cornelissen R, Menten B, Mestdagh P, Vandesompele J, Roost M, Slieker R, Heijmans B, Deforce D, De Sutter P, de Sousa Lopes S, Heindryckx B
    Stem Cells, 2015;33(9):2686-98.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  62. Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor.
    Authors: Zhu G, Fei T, Li Z, Yan X, Chen Y
    J Biol Chem, 2015;290(36):22019-29.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  63. Activin A protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease.
    Authors: Stayte S, Rentsch P, Li K, Vissel B
    PLoS ONE, 2015;10(4):e0124325.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  64. Reprogramming of HUVECs into induced pluripotent stem cells (HiPSCs), generation and characterization of HiPSC-derived neurons and astrocytes.
    Authors: Haile, Yohannes, Nakhaei-Nejad, Maryam, Boakye, Paul A, Baker, Glen, Smith, Peter A, Murray, Allan G, Giuliani, Fabrizio, Jahroudi, Nadia
    PLoS ONE, 2015;10(3):e0119617.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  65. DNA methylation directs functional maturation of pancreatic beta cells.
    Authors: Dhawan S, Tschen S, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A
    J Clin Invest, 2015;125(7):2851-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  66. Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis.
    Authors: Bufalino A, Cervigne N, de Oliveira C, Fonseca F, Rodrigues P, Macedo C, Sobral L, Miguel M, Lopes M, Paes Leme A, Lambert D, Salo T, Kowalski L, Graner E, Coletta R
    PLoS ONE, 2015;10(8):e0136599.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  67. Adipose Stromal Cell Contact with Endothelial Cells Results in Loss of Complementary Vasculogenic Activity Mediated by Induction of Activin A.
    Authors: Merfeld-Clauss S, Lupov I, Lu H, March K, Traktuev D
    Stem Cells, 2015;33(10):3039-51.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  68. Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor beta (TGFbeta)-mediated Germ Layer Induction in Xenopus Embryos.
    Authors: Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen Y, Zhang M, Tao Q, Wu W
    J Biol Chem, 2015;290(28):17239-49.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  69. Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice.
    Authors: Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky T, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, Lin C, Murphy A, Yancopoulos G, Gromada J, Stitt T
    Skelet Muscle, 2015;5(0):34.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  70. HEB associates with PRC2 and SMAD2/3 to regulate developmental fates.
    Authors: Yoon, Se-Jin, Foley, Joseph W, Baker, Julie C
    Nat Commun, 2015;6(0):6546.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  71. The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy.
    Authors: Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y
    PLoS ONE, 2015;10(7):e0133713.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  72. Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
    Authors: Morizane R, Lam A, Freedman B, Kishi S, Valerius M, Bonventre J
    Nat Biotechnol, 2015;33(11):1193-200.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  73. Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
    Authors: Yang J, Wang W, Ooi J, Campos L, Lu L, Liu P
    Stem Cells, 2015;33(5):1390-404.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  74. Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1.
    Authors: Majumder A, Syed K, Joseph S, Scambler P, Dutta D
    J Biol Chem, 2015;290(21):13053-63.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  75. Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.
    Authors: Tamminen J, Yin M, Ronty M, Sutinen E, Pasternack A, Ritvos O, Myllarniemi M, Koli K
    Exp Cell Res, 2015;332(1):102-15.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  76. Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures.
    Authors: Fowler T, Kamalakar A, Akel N, Kurten R, Suva L, Gaddy D
    J Cell Sci, 2015;128(4):683-94.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  77. In vitro generation of human pluripotent stem cell derived lung organoids.
    Authors: Dye, Briana R, Hill, David R, Ferguson, Michael, Tsai, Yu-Hwai, Nagy, Melinda, Dyal, Rachel, Wells, James M, Mayhew, Christop, Nattiv, Roy, Klein, Ophir D, White, Eric S, Deutsch, Gail H, Spence, Jason R
    Elife, 2015;4(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  78. Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells.
    Authors: Pezzolla D, Lopez-Beas J, Lachaud C, Dominguez-Rodriguez A, Smani T, Hmadcha A, Soria B
    PLoS ONE, 2015;10(3):e0119904.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  79. Transcription factor binding dynamics during human ES cell differentiation.
    Authors: Tsankov, Alexande, Gu, Hongcang, Akopian, Veronika, Ziller, Michael, Donaghey, Julie, Amit, Ido, Gnirke, Andreas, Meissner, Alexande
    Nature, 2015;518(7539):344-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  80. Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection.
    Authors: Noguchi, H, Saitoh, I, Tsugata, T, Kataoka, H, Watanabe, M, Noguchi, Y
    Cell Death Differ, 2015;22(1):145-55.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  81. DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation.
    Authors: Czysz, Katherin, Minger, Stephen, Thomas, Nick
    PLoS ONE, 2015;10(2):e0117689.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  82. Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts.
    Authors: Gerbin K, Yang X, Murry C, Coulombe K
    PLoS ONE, 2015;10(7):e0131446.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  83. Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells.
    Authors: Yang W, Liu Y, Slovik K, Wu J, Duncan S, Rader D, Morrisey E
    PLoS ONE, 2015;10(8):e0134995.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  84. Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure.
    Authors: Calderon-Gierszal E, Prins G
    PLoS ONE, 2015;10(7):e0133238.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  85. Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
    Authors: Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A
    Stem Cells, 2015;33(4):1089-101.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  86. The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway.
    Authors: Wilson C, Ottewell P, Coleman R, Holen I
    BMC Cancer, 2015;15(0):55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  87. Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity.
    Authors: Gancarz A, Wang Z, Schroeder G, Damez-Werno D, Braunscheidel K, Mueller L, Humby M, Caccamise A, Martin J, Dietz K, Neve R, Dietz D
    Nat Neurosci, 2015;18(7):959-61.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  88. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
    Nat Protoc, 2015;10(3):413-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  89. Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
    Authors: Kim M, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J
    PLoS ONE, 2015;10(2):e0118670.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  90. Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.
    Authors: Krawchuk D, Anani S, Honma-Yamanaka N, Polito S, Shafik M, Yamanaka Y
    J Cell Sci, 2015;128(5):1011-22.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  91. Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells.
    Authors: Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, Talasila A, Sinha S
    Development, 2015;142(8):1528-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  92. Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells.
    Authors: Wu J, Fan Y, Tzanakakis E
    Stem Cells Dev, 2015;24(7):892-903.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  93. Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
    Authors: Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
    Stem Cells, 2015;33(3):742-50.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  94. Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile.
    Authors: Sugawa F, Arauzo-Bravo M, Yoon J, Kim K, Aramaki S, Wu G, Stehling M, Psathaki O, Hubner K, Scholer H
    EMBO J, 2015;34(8):1009-24.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  95. Generation of articular chondrocytes from human pluripotent stem cells.
    Authors: Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G
    Nat Biotechnol, 2015;33(6):638-45.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  96. Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro.
    Authors: Pethe, Prasad, Nagvenkar, Punam, Bhartiya, Deepa
    BMC Cell Biol, 2014;15(0):18.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  97. Generation of organized germ layers from a single mouse embryonic stem cell.
    Authors: Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N
    Nat Commun, 2014;5(0):4000.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  98. High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.
    Authors: Hakim F, Kaitsuka T, Raeed J, Wei F, Shiraki N, Akagi T, Yokota T, Kume S, Tomizawa K
    J Biol Chem, 2014;289(14):9623-38.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  99. Alteration of skin wound healing in keratinocyte-specific mediator complex subunit 1 null mice.
    Authors: Noguchi F, Nakajima T, Inui S, Reddy J, Itami S
    PLoS ONE, 2014;9(8):e102271.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  100. Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria.
    Authors: Kowno, Megumi, Watanabe-Susaki, Kanako, Ishimine, Hisako, Komazaki, Shinji, Enomoto, Kei, Seki, Yasuhiro, Wang, Ying Yin, Ishigaki, Yohei, Ninomiya, Naoto, Noguchi, Taka-aki, Kokubu, Yuko, Ohnishi, Keigoh, Nakajima, Yoshiro, Kato, Kaoru, Intoh, Atsushi, Takada, Hitomi, Yamakawa, Norio, Wang, Pi-Chao, Asashima, Makoto, Kurisaki, Akira
    PLoS ONE, 2014;9(4):e81552.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  101. Signaling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle.
    Authors: Eresheim, Christin, Leeb, Christia, Buchegger, Patricia, Nimpf, Johannes
    J Biol Chem, 2014;289(14):10182-91.
    Species: Chicken
    Sample Type: Whole Cells
    Application: Bioassay
  102. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang, Sarah X, Islam, Mohammad, O'Neill, John, Hu, Zheng, Yang, Yong-Gua, Chen, Ya-Wen, Mumau, Melanie, Green, Michael, Vunjak-Novakovic, Gordana, Bhattacharya, Jahar, Snoeck, Hans-Wil
    Nat Biotechnol, 2014;32(1):84-91.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  103. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
    Authors: Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, Cordi S, Brindle P, Lemaigre F, Kaestner K, Sosa-Pineda B
    Development, 2014;141(3):538-47.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  104. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.
    Authors: Turnbull I, Karakikes I, Serrao G, Backeris P, Lee J, Xie C, Senyei G, Gordon R, Li R, Akar F, Hajjar R, Hulot J, Costa K
    FASEB J, 2014;28(2):644-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  105. Nodal.Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.
    Authors: Fuerer C, Nostro M, Constam D
    J Biol Chem, 2014;289(25):17854-71.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  106. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
    Authors: Chong J, Yang X, Don C, Minami E, Liu Y, Weyers J, Mahoney W, Van Biber B, Cook S, Palpant N, Gantz J, Fugate J, Muskheli V, Gough G, Vogel K, Astley C, Hotchkiss C, Baldessari A, Pabon L, Reinecke H, Gill E, Nelson V, Kiem H, Laflamme M, Murry C
    Nature, 2014;510(7504):273-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  107. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
    Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
    J Am Soc Nephrol, 2014;25(6):1211-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  108. Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer.
    Authors: Togashi, Yosuke, Sakamoto, Hiroki, Hayashi, Hidetosh, Terashima, Masato, de Velasco, Marco A, Fujita, Yoshihik, Kodera, Yasuo, Sakai, Kazuko, Tomida, Shuta, Kitano, Masayuki, Ito, Akihiko, Kudo, Masatosh, Nishio, Kazuto
    Mol Cancer, 2014;13(0):126.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  109. TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E
    BMC Cancer, 2014;14(0):113.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  110. Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors.
    Authors: Kaitsuka T, Noguchi H, Shiraki N, Kubo T, Wei F, Hakim F, Kume S, Tomizawa K
    Stem Cells Transl Med, 2014;3(1):114-27.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  111. Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells.
    Authors: Fortin J, Boehm U, Weinstein M, Graff J, Bernard D
    FASEB J, 2014;28(3):1474-85.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  112. sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets.
    Authors: Hinton A, Hunter S, Afrikanova I, Jones G, Lopez A, Fogel G, Hayek A, King C
    Stem Cells, 2014;32(9):2360-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  113. Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.
    Authors: Onishi K, Tonge P, Nagy A, Zandstra P
    Stem Cell Reports, 2014;3(1):156-68.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  114. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
    Authors: Shelton M, Metz J, Liu J, Carpenedo R, Demers S, Stanford W, Skerjanc I
    Stem Cell Reports, 2014;3(3):516-29.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  115. A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells.
    Authors: Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, Lu H, Lee M, Chu I, Hwang S
    Stem Cells Dev, 2014;23(4):372-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  116. Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors.
    Authors: Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M
    Stem Cells, 2014;32(8):2178-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  117. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.
    Authors: Guo T, Marmol P, Moliner A, Bjornholm M, Zhang C, Shokat K, Ibanez C
    Elife, 2014;3(0):e03245.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  118. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHbeta gene expression.
    Authors: Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, Magnan C, Migrenne S, Cruciani-Guglielmacci C, Cohen-Tannoudji J
    Endocrinology, 2014;155(2):592-604.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  119. Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells.
    Authors: Massumi M, Hoveizi E, Baktash P, Hooti A, Ghazizadeh L, Nadri S, Pourasgari F, Hajarizadeh A, Soleimani M, Nabiuni M, Khorramizadeh M
    Exp Cell Res, 2014;322(1):51-61.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  120. In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
    Authors: Gouti, Mina, Tsakiridis, Anestis, Wymeersch, Filip J, Huang, Yali, Kleinjung, Jens, Wilson, Valerie, Briscoe, James
    PLoS Biol, 2014;12(8):e1001937.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  121. HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.
    Authors: Watanabe, Hitoshi, Takayama, Kazuo, Inamura, Mitsuru, Tachibana, Masashi, Mimura, Natsumi, Katayama, Kazufumi, Tashiro, Katsuhis, Nagamoto, Yasuhito, Sakurai, Fuminori, Kawabata, Kenji, Furue, Miho Kus, Mizuguchi, Hiroyuki
    PLoS ONE, 2014;9(3):e90791.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  122. A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice.
    Authors: Tsukiyama, Tomoyuki, Ohinata, Yasuhide
    PLoS ONE, 2014;9(4):e95329.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  123. CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision.
    Authors: Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue M, Mizuguchi H
    Development, 2014;141(1):91-100.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  124. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant.
    Authors: Takebe, Takanori, Zhang, Ran-Ran, Koike, Hiroyuki, Kimura, Masaki, Yoshizawa, Emi, Enomura, Masahiro, Koike, Naoto, Sekine, Keisuke, Taniguchi, Hideki
    Nat Protoc, 2014;9(2):396-409.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  125. Enabling autologous human liver regeneration with differentiated adipocyte stem cells.
    Authors: Xu, Dan, Nishimura, Toshihik, Zheng, Ming, Wu, Manhong, Su, Hua, Sato, Noboru, Lee, Gordon, Michie, Sara, Glenn, Jeffrey, Peltz, Gary
    Cell Transplant, 2014;23(12):1573-84.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  126. The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways.
    Authors: Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han J, Li J, Jing N
    Elife, 2014;3(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  127. Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs.
    Authors: Wile B, Ban K, Yoon Y, Bao G
    Nat Protoc, 2014;9(10):2411-24.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  128. Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro.
    Authors: Gao W, Zhou P, Ma X, Tschudy-Seney B, Chen J, Magner N, Revzin A, Nolta J, Zern M, Duan Y
    PLoS ONE, 2014;9(11):e112698.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  129. Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
    Authors: Dambrot C, Braam S, Tertoolen L, Birket M, Atsma D, Mummery C
    J Cell Mol Med, 2014;18(8):1509-18.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  130. An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin.
    Authors: Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza M, Raymon H, Heise C, Daniel T, Chopra R, Sung V
    Br J Haematol, 2014;165(6):870-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  131. A single-cell and feeder-free culture system for monkey embryonic stem cells.
    Authors: Ono T, Suzuki Y, Kato Y, Fujita R, Araki T, Yamashita T, Kato H, Torii R, Sato N
    PLoS ONE, 2014;9(2):e88346.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  132. Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors.
    Authors: Lippmann E, Estevez-Silva M, Ashton R
    Stem Cells, 2014;32(4):1032-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  133. Enzyme-free passage of human pluripotent stem cells by controlling divalent cations.
    Authors: Ohnuma, Kiyoshi, Fujiki, Ayaka, Yanagihara, Kana, Tachikawa, Saoko, Hayashi, Yohei, Ito, Yuzuru, Onuma, Yasuko, Chan, Techuan, Michiue, Tatsuo, Furue, Miho K, Asashima, Makoto
    Sci Rep, 2014;4(0):4646.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  134. Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche.
    Authors: Jorgensen A, Young J, Nielsen J, Joensen U, Toft B, Rajpert-De Meyts E, Loveland K
    Br J Cancer, 2014;110(10):2604-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  135. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.
    Authors: Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R
    Cell Stem Cell, 2014;14(1):53-67.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  136. Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
    Authors: Liu Y, Kaneda R, Leja T, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz R, Barahona M, Schneider M
    Stem Cells, 2014;32(6):1515-26.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  137. Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods.
    Authors: Araoka, Toshikaz, Mae, Shin-ich, Kurose, Yuko, Uesugi, Motonari, Ohta, Akira, Yamanaka, Shinya, Osafune, Kenji
    PLoS ONE, 2014;9(1):e84881.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  138. A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium.
    Authors: Ferrer M, Corneo B, Davis J, Wan Q, Miyagishima K, King R, Maminishkis A, Marugan J, Sharma R, Shure M, Temple S, Miller S, Bharti K
    Stem Cells Transl Med, 2014;3(8):911-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  139. Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo.
    Authors: Luo J, Weaver M, Cao B, Dennis J, Van Biber B, Laflamme M, Allen M
    Stem Cells Transl Med, 2014;3(6):734-44.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  140. Pancreatic insulin-producing cells differentiated from human embryonic stem cells correct hyperglycemia in SCID/NOD mice, an animal model of diabetes.
    Authors: Hua X, Wang Y, Tang Y, Yu S, Jin S, Meng X, Li H, Liu F, Sun Q, Wang H, Li J
    PLoS ONE, 2014;9(7):e102198.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  141. MicroRNA-181a suppresses mouse granulosa cell proliferation by targeting activin receptor IIA.
    Authors: Zhang Q, Sun H, Jiang Y, Ding L, Wu S, Fang T, Yan G, Hu Y
    PLoS ONE, 2013;8(3):e59667.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  142. Human embryonic stem cells differentiate into functional renal proximal tubular-like cells.
    Authors: Narayanan, Karthike, Schumacher, Karl M, Tasnim, Farah, Kandasamy, Karthike, Schumacher, Annegret, Ni, Ming, Gao, Shujun, Gopalan, Began, Zink, Daniele, Ying, Jackie Y
    Kidney Int, 2013;83(4):593-603.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  143. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.
    Authors: Buchholz, David E, Pennington, Britney, Croze, Roxanne, Hinman, Cassidy, Coffey, Peter J, Clegg, Dennis O
    Stem Cells Transl Med, 2013;2(5):384-93.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  144. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells.
    Authors: Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, Matlock B, Weller K, Wu H, Zhao S, Jin P, Dalton S
    Stem Cell Reports, 2013;1(6):532-44.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  145. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman D, Phung C, Kumar N, Willert K
    Cell Death Differ, 2013;20(3):369-81.
  146. Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential.
    Authors: Duggal G, Heindryckx B, Warrier S, O'Leary T, Van der Jeught M, Lierman S, Vossaert L, Deroo T, Deforce D, Chuva de Sousa Lopes S, De Sutter P
    Stem Cells Dev, 2013;22(23):3141-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  147. Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes.
    Authors: Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H
    Stem Cell Reports, 2013;1(4):322-35.
  148. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.
    Authors: Goldman O, Han S, Sourisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton D, Bissig K, Kalir T, Jacobs A, Evans T, Evans M, Gouon-Evans V
    Cell Stem Cell, 2013;12(6):748-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  149. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays.
    Authors: Navarrete E, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge P, Patlolla B, Lee A, Wu H, Beygui R, Wu S, Robbins R, Bers D, Wu J
    Circulation, 2013;128(11):S3-13.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  150. Production of hepatocyte-like cells from human pluripotent stem cells.
    Authors: Hannan, Nicholas, Segeritz, Charis-P, Touboul, Thomas, Vallier, Ludovic
    Nat Protoc, 2013;8(2):430-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  151. Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification.
    Authors: Hoffman J, Wu C, Merrill B
    Development, 2013;140(8):1665-75.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  152. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
    Authors: Mae, Shin-Ich, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhik, Kajiwara, Masatosh, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutosh, Nakayama, Naoki, Cowan, Chad A, Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P, Yamanaka, Shinya, Osafune, Kenji
    Nat Commun, 2013;4(0):1367.
  153. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.
    Authors: White M, Rufaihah A, Liu L, Ghebremariam Y, Ivey K, Cooke J, Srivastava D
    Stem Cells, 2013;31(1):92-103.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  154. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
    Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
    Cell Transplant, 2012;21(6):1321-39.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  155. Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
    Authors: Mottershead D, Ritter L, Gilchrist R
    Mol Hum Reprod, 2012;18(3):121-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  156. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
    Authors: Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S
    Stem Cells Dev, 2012;21(12):2273-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  157. Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
    Authors: Bruce D, Macartney T, Yong W, Shou W, Sapkota G
    Cell Signal, 2012;24(11):1999-2006.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  158. APELIN promotes hematopoiesis from human embryonic stem cells.
    Blood, 2012;119(26):6243-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  159. FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.
    Authors: Sui L, Mfopou J, Geens M, Sermon K, Bouwens L
    Biochem Biophys Res Commun, 2012;426(3):380-5.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  160. Cellular basis of tissue regeneration by omentum.
    Authors: Shah S, Lowery E, Braun RK
    PLoS ONE, 2012;7(6):e38368.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  161. The endothelial cell line bEnd.3 maintains human pluripotent stem cells.
    Authors: Joubin, Katherin, Richardson, Amelia, Novoa, Natalia, Tu, Edmund, Tomishima, Mark J
    Stem Cells Dev, 2012;21(12):2312-21.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  162. Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.
    Authors: Pereira P, Dobreva M, Maas E, Cornelis F, Moya I, Umans L, Verfaillie C, Camus A, de Sousa Lopes S, Huylebroeck D, Zwijsen A
    Development, 2012;139(18):3343-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  163. Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model.
    Authors: Jeon, Kilsoo, Lim, Hyejin, Kim, Jung-Hyu, Thuan, Nguyen V, Park, Seung Hw, Lim, Yu-Mi, Choi, Hye-Yeon, Lee, Eung-Ryo, Kim, Jin-Hoi, Lee, Myung-Sh, Cho, Ssang-Go
    Stem Cells Dev, 2012;21(14):2642-55.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  164. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
    Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
    Nature, 2012;491(7426):765-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  165. Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
    Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
    J. Biol. Chem., 2011;286(34):30034-46.
    Species: Human
    Sample Type: Recombinant Protein
    Application: Surface Plasmon Resonance
  166. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
    Authors: Spence JR, Mayhew CN, Rankin SA
    Nature, 2011;470(7332):105-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  167. Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals.
    Authors: Zhang Q, Jiang J, Han P, Yuan Q, Zhang J, Zhang X, Xu Y, Cao H, Meng Q, Chen L, Tian T, Wang X, Li P, Hescheler J, Ji G, Ma Y
    Cell Res., 2011;21(4):579-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  168. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
    Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
    Stem Cells, 2011;29(6):964-71.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  169. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
    Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
    PLoS ONE, 2010;5(8):e12101.
    Species: Human
    Sample Type: Whole Cells
    Application: differentiation
  170. The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers.
    Authors: Emre N, Vidal JG, Elia J
    PLoS ONE, 2010;5(8):e12148.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  171. Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm.
    Authors: Chayosumrit M, Tuch B, Sidhu K
    Biomaterials, 2010;31(3):505-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  172. A defined glycosaminoglycan-binding substratum for human pluripotent stem cells.
    Authors: Klim JR, Li L, Wrighton PJ
    Nat. Methods, 2010;7(12):989-94.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  173. BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation.
    Authors: Tramullas M, Lantero A, Diaz A, Morchon N, Merino D, Villar A, Buscher D, Merino R, Hurle JM, Izpisua-Belmonte JC, Hurle MA
    J. Neurosci., 2010;30(4):1502-11.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  174. SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.
    Authors: Chng Z, Teo A, Pedersen RA, Vallier L
    Cell Stem Cell, 2010;6(1):59-70.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  175. Scaffold-free human cardiac tissue patch created from embryonic stem cells.
    Authors: Stevens KR, Pabon L, Muskheli V
    Tissue Eng Part A, 2009;15(6):1211-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  176. Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis.
    Authors: Dickinson RE, Stewart AJ, Myers M, Millar RP, Duncan WC
    Endocrinology, 2009;150(6):2873-81.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  177. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
    Authors: Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
    Cell Stem Cell, 2009;4(4):348-58.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  178. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
    Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
    Dev. Biol., 2009;330(2):286-304.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  179. Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells.
    Authors: Bernardo AS, Cho CH, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K
    Stem Cells, 2009;27(2):341-51.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  180. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
    Authors: Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM
    Nature, 2008;453(7194):524-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  181. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
    Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
    Cell Stem Cell, 2008;2(6):602-12.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  182. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling.
    Authors: Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V
    Blood, 2008;112(8):3154-63.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  183. Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.
    Authors: Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, Gao Y, Dai H, Yuan J, Cheng L, Xiao L
    J. Biol. Chem., 2008;283(36):24991-5002.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  184. Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.
    Authors: Shiraki N, Yoshida T, Araki K, Umezawa A, Higuchi Y, Goto H, Kume K, Kume S
    Stem Cells, 2008;26(4):874-85.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  185. Lrp6 is required for convergent extension during Xenopus gastrulation.
    Authors: Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E
    Development, 2007;134(22):4095-106.
    Species: Xenopus
    Sample Type: Whole Tissue
    Application: Bioassay
  186. Effect of insulin-like growth factor-binding protein 7 on steroidogenesis in granulosa cells derived from equine chorionic gonadotropin-primed immature rat ovaries.
    Authors: Tamura K, Matsushita M, Endo A, Kutsukake M, Kogo H
    Biol. Reprod., 2007;77(3):485-91.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  187. Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.
    Authors: Oki S, Hashimoto R, Okui Y, Shen MM, Mekada E, Otani H, Saijoh Y, Hamada H
    Development, 2007;134(21):3893-904.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  188. Predicting evolutionary patterns of mammalian teeth from development.
    Authors: Kavanagh KD, Evans AR, Jernvall J
    Nature, 2007;449(7161):427-32.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  189. New cell lines from mouse epiblast share defining features with human embryonic stem cells.
    Authors: Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD
    Nature, 2007;448(7150):196-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  190. The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases.
    Authors: Kupershmidt L, Amit T, Bar-Am O, Youdim MB, Blumenfeld Z
    J. Neurochem., 2007;103(3):962-71.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  191. Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
    Authors: Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S
    Cell, 2007;131(5):861-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  192. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells.
    Authors: Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK
    Biochem. Biophys. Res. Commun., 2007;366(1):129-34.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  193. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed.
    Authors: McLean AB, D&amp;amp;apos;Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, Dalton S
    Stem Cells, 2007;25(1):29-38.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  194. Prospective isolation and global gene expression analysis of definitive and visceral endoderm.
    Authors: Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA
    Dev. Biol., 2007;304(2):541-55.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  195. Conditional gene expression in human embryonic stem cells.
    Authors: Vallier L, Alexander M, Pedersen R
    Stem Cells, 2007;25(6):1490-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  196. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.
    Authors: Wang L, Schulz TC, Sherrer ES, Dauphin DS, Shin S, Nelson AM, Ware CB, Zhan M, Song CZ, Chen X, Brimble SN, McLean A, Galeano MJ, Uhl EW, D'Amour KA, Chesnut JD, Rao MS, Blau CA, Robins AJ
    Blood, 2007;110(12):4111-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  197. A large-scale proteomic analysis of human embryonic stem cells.
    Authors: Schulz TC, Swistowska AM, Liu Y
    BMC Genomics, 2007;8(0):478.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  198. Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
    Authors: Alexander S, Watt F, Sawaji Y, Hermansson M, Saklatvala J
    Arthritis Rheum., 2007;56(11):3715-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  199. The activin A-follistatin system: potent regulator of human extracellular matrix mineralization.
    Authors: Eijken M, Swagemakers S, Koedam M, Steenbergen C, Derkx P, Uitterlinden AG, van der Spek PJ, Visser JA, de Jong FH, Pols HA, van Leeuwen JP
    FASEB J., 2007;21(11):2949-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  200. Stem cells derived from human fetal membranes display multilineage differentiation potential.
    Authors: Ilancheran S, Michalska A, Peh G, Wallace EM, Pera M, Manuelpillai U
    Biol. Reprod., 2007;77(3):577-88.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  201. The activin-follistatin system and in vitro early follicle development in goats.
    Authors: Silva JR, Tharasanit T, Taverne MA, van der Weijden GC, Santos RR, Figueiredo JR, van den Hurk R
    J. Endocrinol., 2006;189(1):113-25.
    Species: Goat
    Sample Type: Whole Tissue
    Application: Bioassay
  202. The role of the activin system in keloid pathogenesis.
    Authors: Mukhopadhyay A, Chan SY, Lim IJ, Phillips DJ, Phan TT
    Am. J. Physiol., Cell Physiol., 2006;292(4):C1331-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  203. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.
    Authors: Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S
    Proc. Natl. Acad. Sci. U.S.A., 2006;103(18):6907-12.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  204. Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal.
    Authors: Greber B, Lehrach H, Adjaye J
    Stem Cells, 2006;25(2):455-64.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  205. Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells.
    Authors: Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K
    Stem Cells, 2006;24(9):2014-22.
    Species: Primate - Callitrix jacchus (Common Marmoset)
    Sample Type: Whole Cells
    Application: Bioassay
  206. Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer.
    Authors: Ng RK, Gurdon JB
    Proc. Natl. Acad. Sci. U.S.A., 2005;102(6):1957-62.
    Species: Xenopus
    Sample Type: Whole Cells
    Application: Bioassay
  207. Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts.
    Authors: Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J
    Arthritis Rheum., 2004;50(8):2521-30.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  208. Immunoneutralization of growth differentiation factor 9 reveals it partially accounts for mouse oocyte mitogenic activity.
    Authors: Gilchrist RB, Ritter LJ, Cranfield M, Jeffery LA, Amato F, Scott SJ, Myllymaa S, Kaivo-Oja N, Lankinen H, Mottershead DG, Groome NP, Ritvos O
    Biol. Reprod., 2004;71(3):732-9.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  209. Paracrine regulation of FSH by follistatin in folliculostellate cell-enriched primate pituitary cell cultures.
    Authors: Kawakami S, Fujii Y, Okada Y, Winters SJ
    Endocrinology, 2002;143(6):2250-8.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  210. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence.
    Authors: Grimm OH, Gurdon JB
    Nat. Cell Biol., 2002;4(7):519-22.
    Species: Xenopus
    Sample Type: Whole Cells
    Application: Bioassay
Expand to show all 210 Citations
Animal Component Free Recombinant Proteins
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Recombinant Human/Mouse/Rat Activin A, ACFP Protein

BA ACFP338
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