Recombinant Human PDGF-BB Protein, CF

GMP Version Available: 220-GMP
GMP
Catalog # Availability Size / Price Qty
220-BB-010
220-BB-050
220-BB-01M
220-BB-200
Recombinant Human PDGF-BB Protein SDS-PAGE
2 Images
Product Details
Citations (136)
FAQs
Supplemental Products
Reviews (10)

Recombinant Human PDGF-BB Protein, CF Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED50 for this effect is 1.5-6 ng/mL.
The specific activity of Recombinant Human PDGF-BB is approximately 1.9 x 106 IU/mg, which is calibrated against recombinant human PDGF-BB WHO International Standard (NIBSC code: 94/728).   Specific activity is for reference purposes only and is not routinely tested.  
Source
E. coli-derived human PDGF-BB protein
Ser82-Thr190
Accession #
N-terminal Sequence
Analysis
Ser82
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
12.3 kDa (monomer)
SDS-PAGE
12 kDa, reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

220-BB

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

SDS-PAGE Recombinant Human PDGF-BB Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human PDGF-BB was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 13 kDa and 28 kDa, respectively.

Bioactivity Recombinant Human PDGF-BB Protein Bioactivity View Larger

Recombinant Human PDGF-BB (Catalog # 220-BB) stimulates cell proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner. The ED50 for this effect is 1.5-6 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: PDGF-BB

Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the alpha ‑granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGF-AA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed alpha and beta. Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL-2 secretion accompanied by a down-regulation of IL-4 and IFN-gamma production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.

Long Name
Platelet-derived Growth Factor BB
Entrez Gene IDs
5155 (Human); 24628 (Rat)
Alternate Names
PDGFBB; PDGF-BB

Citations for Recombinant Human PDGF-BB Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

136 Citations: Showing 1 - 10
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  1. Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl4 and TAA-Induced Liver Fibrosis in Mice
    Authors: YJ Liao, YH Wang, CY Wu, FY Hsu, CY Chien, YC Lee
    International Journal of Molecular Sciences, 2021;22(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Gold Nanoparticles Affect Pericyte Biology and Capillary Tube Formation
    Authors: S Looprasert, A Sereemaspu, N Kitkumthor, K Sooklert, T Sarachana, D Jindatip
    Pharmaceutics, 2021;13(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy
    Authors: S Yang, H Li, H Yao, Y Zhang, H Bao, L Wu, C Zhang, M Li, L Feng, J Zhang, Z Zheng, G Xu, F Wang
    Cell Death and Differentiation, 2021;0(0):.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: Bioassay
  4. Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells
    Authors: SK Meurer, O Tezcan, T Lammers, R Weiskirche
    Cell. Signal., 2020;74(0):109731.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis
    Authors: M Oka, S Shimo, N Ohno, H Imai, Y Abekura, H Koseki, H Miyata, K Shimizu, M Kushamae, I Ono, K Nozaki, A Kawashima, T Kawamata, T Aoki
    Sci Rep, 2020;10(1):8330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds
    Authors: M Aliabouzar, A Jivani, X Lu, OD Kripfgans, JB Fowlkes, ML Fabiilli
    Ultrason Sonochem, 2020;66(0):105109.
    Species: Synthetic
    Sample Types: Synthetic emulsion construct
    Applications: novel - monodisperse double em
  7. PERK Inhibition Mitigates Restenosis and�Thrombosis: A Potential Low-Thrombogenic Antirestenotic Paradigm
    Authors: B Wang, M Zhang, G Urabe, Y Huang, G Chen, D Wheeler, DJ Dornbos, A Huttinger, SM Nimjee, S Gong, LW Guo, KC Kent
    JACC Basic Transl Sci, 2020;5(3):245-263.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice
    Authors: X Li, S Shao, H Li, Z Bi, S Zhang, Y Wei, J Bai, R Zhang, X Ma, B Ma, L Zhang, C Xie, W Ning, H Zhou, C Yang
    J. Cell. Mol. Med., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells
    Authors: W Chen, J Lin, B Li, S Cao, H Li, J Zhao, K Liu, Y Li, Y Li, S Sun
    J. Cell. Mol. Med., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  10. Vascular Smooth Muscle Cell-Derived Exosomal MicroRNAs Regulate Endothelial Cell Migration Under PDGF Stimulation
    Authors: J Heo, HC Yang, WJ Rhee, H Kang
    Cells, 2020;9(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model
    Authors: Y Yamamoto, A Mukai, T Ikushima, Y Urata, S Kinoshita, J Hamuro, M Ueno, C Sotozono
    Scientific Reports, 2020;10(1):20936.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. Zinc salicylate reduces airway smooth muscle cells remodelling by blocking mTOR and activating p21(Waf1/Cip1)
    Authors: L Fang, M Roth, C Teck S'ng, M Tamm, B Han, BX Hoang
    The Journal of nutritional biochemistry, 2020;0(0):108563.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease
    Authors: K Song, Y Qing, Q Guo, EK Peden, C Chen, WE Mitch, L Truong, J Cheng
    JCI Insight, 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner
    Authors: YY Liang, XB Deng, XT Lin, LL Jiang, XT Huang, ZW Mo, YW Yuan, MT Teh
    Cell Death Dis, 2020;11(10):855.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. TGFb acts through PDGFRb to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression
    Authors: S Maity, F Das, BS Kasinath, N Ghosh-Chou, G Ghosh Chou
    J. Biol. Chem., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
    Authors: L Song, Z Liu, HH Hu, Y Yang, TY Li, ZZ Lin, J Ye, J Chen, X Huang, DT Liu, J Zhou, Y Shi, H Zhao, C Xie, L Chen, E Song, SY Lin, SC Lin
    Nat Commun, 2020;11(1):5842.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair
    Authors: T Colunga, M Hayworth, S Kre beta, DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton
    Cell Rep, 2019;26(10):2566-2579.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. MicroRNA-320 targeting neuropilin 1 inhibits proliferation and migration of vascular smooth muscle cells and neointimal formation
    Authors: H Li, J Zhao, B Liu, J Luo, Z Li, X Qin, Y Wei
    Int J Med Sci, 2019;16(1):106-114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Possible contribution of PDGF-BB-induced autophagy in dermatofibrosarcoma protuberans: Autophagy marker Atg5 could be a differential marker between dermatofibrosarcoma protuberans and dermatofibroma
    Authors: SI Motegi, C Fujiwara, A Sekiguchi, S Yamazaki, Y Yokoyama, M Yasuda, O Ishikawa
    J. Dermatol. Sci., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK suppression
    Authors: Y Higashi, S Mummidi, S Sukhanov, T Yoshida, M Noda, P Delafontai, B Chandrasek
    Cell. Signal., 2019;57(0):20-Oct.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells
    Authors: MFM Gerli, LA Moyle, S Benedetti, G Ferrari, E Ucuncu, M Ragazzi, C Constantin, I Louca, H Sakai, P Ala, P De Coppi, S Tajbakhsh, G Cossu, FS Tedesco
    Stem Cell Reports, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
    Authors: Y Kano, T Gebregiwor, CB Marshall, N Radulovich, BPK Poon, J St-Germain, JD Cook, I Valencia-S, BMM Grant, SG Herrera, J Miao, B Raught, MS Irwin, JE Lee, JJ Yeh, ZY Zhang, MS Tsao, M Ikura, M Ohh
    Nat Commun, 2019;10(1):224.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels
    Authors: T Emi, K Michaud, E Orton, G Santilli, C Linh, M O'Connell, F Issa, S Kennedy
    Molecules, 2019;24(6):.
    Applications: Bioassay
  24. IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance
    Authors: T Muraguchi, D Nanba, EK Nishimura, T Tashiro
    J. Dermatol. Sci., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Adult Human Dermal Progenitor Cell Transplantation Modulates the Functional Outcome of Split-Thickness Skin Xenografts
    Authors: NA Agabalyan, HD Sparks, S Tarraf, NL Rosin, K Anker, G Yoon, LN Burnett, D Nickerson, ES Di Martino, VA Gabriel, J Biernaskie
    Stem Cell Reports, 2019;13(6):1068-1082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation
    Authors: L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn
    Mol. Vis., 2019;25(0):329-344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation
    Authors: TN Vu, X Chen, HD Foda, GC Smaldone, NA Hasaneen
    Respir. Res., 2019;20(1):206.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. miR-29a Regulates the Proliferation and Migration of Human Arterial Smooth Muscle Cells in Arteriosclerosis Obliterans of the Lower Extremities
    Authors: K Wang, J Yu, B Wang, H Wang, Z Shi, G Li
    Kidney Blood Press. Res., 2019;44(5):1219-1232.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARgamma
    Authors: P Luan, W Jian, X Xu, W Kou, Q Yu, H Hu, D Li, W Wang, MW Feinberg, J Zhuang, Y Xu, W Peng
    Nat Commun, 2019;10(1):2882.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Mechanism of anti-remodelling action of treprostinil in human pulmonary arterial smooth muscle cells
    Authors: C Lambers, C Kornauth, F Oberndorfe, PM Boehm, M Tamm, W Klepetko, M Roth
    PLoS ONE, 2018;13(11):e0205195.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis
    Authors: L Peix, IC Evans, DR Pearce, JK Simpson, TM Maher, RJ McAnulty
    Sci Rep, 2018;8(1):1906.
    Species: Human
    Sample Types: Whole Cells
  32. Telomere shortening is a hallmark of genetic cardiomyopathies
    Authors: ACY Chang, ACH Chang, A Kirillova, K Sasagawa, W Su, G Weber, J Lin, V Termglinch, I Karakikes, T Seeger, AM Dainis, JT Hinson, J Seidman, CE Seidman, JW Day, E Ashley, JC Wu, HM Blau
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
    Authors: A Dubrac, SE Künzel, SH Künzel, J Li, RR Chandran, K Martin, DM Greif, RH Adams, A Eichmann
    Nat Commun, 2018;9(1):3463.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  34. Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier
    Authors: L Delsing, P Dönnes, J Sánchez, M Clausen, D Voulgaris, A Falk, A Herland, G Brolén, H Zetterberg, R Hicks, J Synnergren
    Stem Cells, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells
    Authors: VC Pai, IC Lo, YW Huang, IC Tsai, HP Cheng, GY Shi, HL Wu, MJ Jiang
    J. Biomed. Sci., 2018;25(1):14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity
    Authors: M Zhang, G Urabe, C Little, B Wang, AM Kent, Y Huang, KC Kent, LW Guo
    JACC Basic Transl Sci, 2018;3(6):782-795.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1? on rheumatoid arthritis fibroblast-like synoviocytes
    Authors: B Bergström, H Carlsten, AH Ekwall
    Arthritis Res. Ther., 2018;20(1):49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy
    Authors: Y Zhang, D Zhao, S Yang, H Yao, M Li, C Zhao, J Zhang, GT Xu, H Li, F Wang
    Cell. Physiol. Biochem., 2018;46(4):1704-1715.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: In Vivo
  39. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain
    Authors: JM Dave, T Mirabella, SD Weatherbee, DM Greif
    Dev. Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis
    Authors: LR Penke, JM Speth, VL Dommeti, ES White, IL Bergin, M Peters-Gol
    J. Clin. Invest., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells
    Authors: R Sambathkum, R Akkerman, S Dastidar, P Roelandt, M Kumar, M Bajaj, AR Mestre Ros, N Helsen, V Vanslembro, E Kalo, S Khurana, J Laureys, C Gysemans, MM Faas, P de Vos, CM Verfaillie
    PLoS ONE, 2018;13(5):e0197046.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Urethral reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model
    Authors: Y Liu, W Ma, B Liu, Y Wang, J Chu, G Xiong, L Shen, C Long, T Lin, D He, D Butnaru, L Alexey, Y Zhang, D Zhang, G Wei
    Stem Cell Res Ther, 2017;8(1):63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling
    Authors: KB Sugg, JF Markworth, NP Disser, AM Rizzi, JR Talarek, DC Sarver, SV Brooks, CL Mendias
    Am. J. Physiol., Cell Physiol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-? as a key for entry
    Authors: Y Wu, A Prager, S Boos, M Resch, I Brizic, M Mach, S Wildner, L Scrivano, B Adler
    PLoS Pathog., 2017;13(4):e1006281.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Platelet-Derived Growth Factor BB Influences Muscle Regeneration in Duchenne Muscle Dystrophy
    Authors: P Piñol-Jura, E Gallardo, N de Luna, X Suárez-Cal, C Sánchez-Ri, E Fernández-, C Gomis, I Illa, J Díaz-Maner
    Am. J. Pathol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics
    Authors: SB Mamer, S Chen, JC Weddell, A Palasz, A Wittenkell, M Kumar, PI Imoukhuede
    Sci Rep, 2017;7(1):16439.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  47. Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling
    Authors: S Pan, H Lin, H Luo, F Gao, L Meng, C Zhou, C Jiang, Y Guo, Z Ji, J Chi, H Guo
    Am J Transl Res, 2017;9(3):1307-1316.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Combination therapy using molecular-targeted drugs modulates tumor microenvironment and impairs tumor growth in renal cell carcinoma
    Authors: H Kitano, Y Kitadai, J Teishima, R Yuge, S Shinmei, K Goto, S Inoue, T Hayashi, K Sentani, W Yasui, A Matsubara
    Cancer Med, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis
    Authors: TH Su, CW Shiau, P Jao, NJ Yang, WT Tai, CJ Liu, TC Tseng, HC Yang, CH Liu, KW Huang, TC Hu, YJ Huang, YM Wu, LJ Chen, PJ Chen, DS Chen, KF Chen, JH Kao
    Sci Rep, 2017;7(1):1728.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure
    Authors: M Dagnell, PE Pace, Q Cheng, J Frijhoff, A Östman, ESJ Arnér, MB Hampton, CC Winterbour
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling
    Authors: D Pap, E Sziksz, Z Kiss, R Rokonay, A Veres-Szék, R Lippai, IM Takács, É Kis, A Fekete, G Reusz, A Vannay, AJ Szabó
    Kidney Blood Press. Res, 2017;42(1):16-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype
    Authors: TM Wang, KC Chen, PY Hsu, HF Lin, YS Wang, CY Chen, YC Liao, SH Juo
    J. Cell. Mol. Med., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation
    Authors: R Núñez-Told, E Martínez-S, C Gil-Recio, MÁ Carrasco, A Al Madhoun, S Montori, M Atari
    BMC Cell Biol., 2017;18(1):21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. miR-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways
    Authors: Robert M Lavker
    FASEB J., 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Pericyte-fibroblast transition promotes tumor growth and metastasis
    Proc Natl Acad Sci USA, 2016;113(38):E5618-E5627.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Interferon-? blocks signalling through PDGFR? in human brain pericytes
    J Neuroinflammation, 2016;13(1):249.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Biological characteristics of embryonic epicardial cells in vitro correlate with embryonic day
    Authors: Xiaoming Wei
    Acta Biochim. Biophys. Sin. (Shanghai), 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Mesenchymal Stem Cells Reshape and Provoke Proliferation of Articular Chondrocytes by Paracrine Secretion
    Sci Rep, 2016;6(0):32705.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow-derived counterparts
    J Tissue Eng, 2016;7(0):2041731416661.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Isoquercitrin protects against pulmonary hypertension via inhibiting PASMCs proliferation
    Authors: Haipeng Guo
    Clin. Exp. Pharmacol. Physiol., 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas
    Authors: DH Heiland, R Ferrarese, R Claus, F Dai, AP Masilamani, E Kling, A Weyerbrock, T Kling, S Nelander, MS Carro
    Oncotarget, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
    Nat Commun, 2016;7(0):12092.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Zedoarondiol Inhibits Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells Proliferation via Regulating AMP-Activated Protein Kinase Signaling Pathway
    Authors: Huimin Mao
    Cell. Physiol. Biochem, 2016;40(6):1506-1520.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Platelet-Derived Growth Factor in the Ovarian Follicle Attracts the Stromal Cells of the Fallopian Tube Fimbriae
    PLoS ONE, 2016;11(7):e0158266.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation Through Toll-Like Receptor Signaling.
    Authors: Amarachintha S, Sertorio M, Wilson A, Li X, Pang Q
    Stem Cells, 2015;33(11):3382-96.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Thrombomodulin promotes corneal epithelial wound healing.
    Authors: Huang, Yi-Hsun, I, Ching-Ch, Kuo, Cheng-Hs, Hsu, Yun-Yan, Lee, Fang-Tzu, Shi, Guey-Yue, Tseng, Sung-Hue, Wu, Hua-Lin
    PLoS ONE, 2015;10(3):e0122491.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Hsp90alpha and Hsp90beta together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing.
    Authors: Jayaprakash P, Dong H, Zou M, Bhatia A, O'Brien K, Chen M, Woodley D, Li W
    J Cell Sci, 2015;128(8):1475-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells from Subjects with Pulmonary Arterial Hypertension Is Activated through JNK and p38 MAPK.
    Authors: Wilson J, Yu J, Taylor L, Polgar P
    , 2015;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice.
    Authors: Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J
    PLoS ONE, 2015;10(3):e0121939.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
    Authors: Bogershausen N, Tsai I, Pohl E, Kiper P, Beleggia F, Percin E, Keupp K, Matchan A, Milz E, Alanay Y, Kayserili H, Liu Y, Banka S, Kranz A, Zenker M, Wieczorek D, Elcioglu N, Prontera P, Lyonnet S, Meitinger T, Stewart A, Donnai D, Strom T, Boduroglu K, Yigit G, Li Y, Katsanis N, Wollnik B
    J Clin Invest, 2015;125(9):3585-99.
  71. Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis.
    Authors: Hayes B, Riehle K, Shimizu-Albergine M, Bauer R, Hudkins K, Johansson F, Yeh M, Mahoney W, Yeung R, Campbell J
    PLoS ONE, 2014;9(3):e92925.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Imatinib mesylate exerts anti-proliferative effects on osteosarcoma cells and inhibits the tumour growth in immunocompetent murine models.
    Authors: Gobin B, Moriceau G, Ory B, Charrier C, Brion R, Blanchard F, Redini F, Heymann D
    PLoS ONE, 2014;9(3):e90795.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells.
    Authors: Yang, Wei, Ramachandran, Aruna, You, Sungyong, Jeong, HyoBin, Morley, Samantha, Mulone, Michelle, Logvinenko, Tanya, Kim, Jayoung, Hwang, Daehee, Freeman, Michael, Adam, Rosalyn
    Cell Commun Signal, 2014;12(1):44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Human corneal stromal stem cells exhibit survival capacity following isolation from stored organ-culture corneas.
    Authors: Kureshi A, Funderburgh J, Daniels J
    Invest Ophthalmol Vis Sci, 2014;55(11):7583-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRbeta aptamer.
    Authors: Camorani S, Esposito C, Rienzo A, Catuogno S, Iaboni M, Condorelli G, de Franciscis V, Cerchia L
    Mol Ther, 2014;22(4):828-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation.
    Authors: Oleinik N, Helke K, Kistner-Griffin E, Krupenko N, Krupenko S
    J Biol Chem, 2014;289(38):26383-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Lutein inhibits the migration of retinal pigment epithelial cells via cytosolic and mitochondrial Akt pathways (lutein inhibits RPE cells migration).
    Authors: Su C, Chan C, Chen H, Wu C, Hsiao C, Lee P, Lin V, Hung C
    Int J Mol Sci, 2014;15(8):13755-67.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development.
    Authors: Kondo, Shunya, Bottos, Alessia, Allegood, Jeremy C, Masson, Regis, Maurer, Francisc, Genoud, Christel, Kaeser, Patrick, Huwiler, Andrea, Murakami, Masato, Spiegel, Sarah, Hynes, Nancy E
    PLoS ONE, 2014;9(4):e94114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor.
    Authors: Tsai T, Shih S, Ho T, Ma H, Liu M, Chen S, Tsao Y
    PLoS ONE, 2014;9(4):e95443.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
    Authors: Miller C, Haas U, Diaz R, Leeper N, Kundu R, Patlolla B, Assimes T, Kaiser F, Perisic L, Hedin U, Maegdefessel L, Schunkert H, Erdmann J, Quertermous T, Sczakiel G
    PLoS Genet, 2014;10(3):e1004263.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma.
    Authors: Zhang, Y, Kim, J, Mueller, A C, Dey, B, Yang, Y, Lee, D-h, Hachmann, J, Finderle, S, Park, D M, Christensen, J, Schiff, D, Purow, B, Dutta, A, Abounader, R
    Cell Death Differ, 2014;21(5):720-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways.
    Authors: Lo H, Lai T, Li C, Wu W
    Acta Pharmacol Sin, 2014;35(3):339-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis.
    Authors: Wollin L, Maillet I, Quesniaux V, Holweg A, Ryffel B
    J Pharmacol Exp Ther, 2014;349(2):209-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.
    Authors: Hostettler K, Zhong J, Papakonstantinou E, Karakiulakis G, Tamm M, Seidel P, Sun Q, Mandal J, Lardinois D, Lambers C, Roth M
    Respir Res, 2014;15(1):157.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Src-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites.
    Authors: Gottlieb-Abraham, Efrat, Shvartsman, Dmitry E, Donaldson, John C, Ehrlich, Marcelo, Gutman, Orit, Martin, G Steven, Henis, Yoav I
    Mol Biol Cell, 2013;24(24):3881-95.
    Species: Primate - Chlorocebus aethiops (African Green Monkey)
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Thrombin induces epithelial-mesenchymal transition and collagen production by retinal pigment epithelial cells via autocrine PDGF-receptor signaling.
    Authors: Bastiaans J, van Meurs J, van Holten-Neelen C, Nagtzaam N, van Hagen P, Chambers R, Hooijkaas H, Dik W
    Invest Ophthalmol Vis Sci, 2013;54(13):8306-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration.
    Authors: Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G
    J Biol Chem, 2013;288(43):30815-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Inactivation of nuclear factor-Y inhibits vascular smooth muscle cell proliferation and neointima formation.
    Authors: Silvestre-Roig C, Fernandez P, Esteban V, Pello O, Indolfi C, Rodriguez C, Rodriguez-Calvo R, Lopez-Maderuelo M, Bauriedel G, Hutter R, Fuster V, Ibanez B, Redondo J, Martinez-Gonzalez J, Andres V
    Arterioscler Thromb Vasc Biol, 2013;33(5):1036-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. ROS-mediated downregulation of MYPT1 in smooth muscle cells: a potential mechanism for the aberrant contractility in atherosclerosis.
    Authors: Cheng J, Cheng H, Tsai I, Jiang M
    Lab Invest, 2013;93(4):422-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency.
    Authors: Li, Wei, Li, Qingle, Qin, Lingfeng, Ali, Rahmat, Qyang, Yibing, Tassabehji, May, Pober, Barbara, Sessa, William, Giordano, Frank J, Tellides, George
    Arterioscler Thromb Vasc Biol, 2013;33(5):1028-35.
    Species: Human
    Sample Types: Serum
    Applications: Bioassay
  91. Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation.
    Authors: Karki R, Kim S, Kim D
    Exp Cell Res, 2013;319(20):3238-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Cytotoxic effects of curcumin in human retinal pigment epithelial cells.
    Authors: Hollborn M, Chen R, Wiedemann P, Reichenbach A, Bringmann A, Kohen L
    PLoS ONE, 2013;8(3):e59603.
  93. Distinct transcriptional profiles of angioblasts derived from human embryonic stem cells.
    Authors: Song S, Jung W, Kim K, Hong W, Kim H, Lee K, Lee K, Suh W
    Exp Cell Res, 2013;319(8):1136-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
    Authors: Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I
    Stem Cells, 2012;30(7):1455-64.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. TH17 cytokines induce human airway smooth muscle cell migration.
    Authors: Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH
    J. Allergy Clin. Immunol., 2011;127(4):1046-53.e1-2.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4.
    Authors: Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A
    J. Biol. Chem., 2011;286(32):28097-110.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells.
    Authors: Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P
    Mol. Cell. Biol., 2011;31(6):1174-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions.
    Authors: Roobrouck VD, Clavel C, Jacobs SA, Ulloa-Montoya F, Crippa S, Sohni A, Roberts SJ, Luyten FP, Van Gool SW, Sampaolesi M, Delforge M, Luttun A, Verfaillie CM
    Stem Cells, 2011;29(5):871-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
    Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
    PLoS ONE, 2010;5(8):e12101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  100. Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment.
    Authors: Lorquet S, Berndt S, Blacher S, Gengoux E, Peulen O, Maquoi E, Noel A, Foidart JM, Munaut C, Pequeux C
    FASEB J., 2010;24(10):3782-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. KSHV-induced notch components render endothelial and mural cell characteristics and cell survival.
    Authors: Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary PM, Jung J, Gill PS
    Blood, 2010;115(4):887-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  102. Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
    Authors: Ball SG, Bayley C, Shuttleworth CA, Kielty CM
    Biochem. J., 2010;427(1):29-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
    Authors: Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV
    Oncogene, 2010;29(20):2938-49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways.
    Authors: Shan L, Redhu NS, Saleh A
    J. Immunol., 2010;184(12):7134-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression.
    Authors: Wagsater D, Zhu C, Bjorck HM, Eriksson P
    Atherosclerosis, 2009;202(2):415-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy.
    Authors: van Steensel L, Paridaens D, Schrijver B, Dingjan GM, van Daele PL, van Hagen PM, van den Bosch WA, Drexhage HA, Hooijkaas H, Dik WA
    Invest. Ophthalmol. Vis. Sci., 2009;50(7):3091-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells.
    Authors: Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, Tanaka A, Kusano E
    Kidney Int., 2009;75(11):1173-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  108. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
    Authors: Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ
    Cancer Res., 2008;68(12):4774-82.
  109. Pax3 activation promotes the differentiation of mesenchymal stem cells toward the myogenic lineage.
    Authors: Gang EJ, Bosnakovski D, Simsek T, To K, Perlingeiro RC
    Exp. Cell Res., 2008;314(8):1721-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells.
    Authors: Nedeau AE, Bauer RJ, Gallagher K, Chen H, Liu ZJ, Velazquez OC
    Exp. Cell Res., 2008;314(11):2176-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Temporally expressed PDGF and FGF-2 regulate embryonic coronary artery formation and growth.
    Authors: Tomanek RJ, Hansen HK, Christensen LP
    Arterioscler. Thromb. Vasc. Biol., 2008;28(7):1237-43.
    Species: Avian
    Sample Types: Whole Tissue
    Applications: Bioassay
  112. Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
    Authors: Rice JW, Veal JM, Fadden RP, Barabasz AF, Partridge JM, Barta TE, Dubois LG, Huang KH, Mabbett SR, Silinski MA, Steed PM, Hall SE
    Arthritis Rheum., 2008;58(12):3765-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Connective tissue growth factor as a mediator of intraocular fibrosis.
    Authors: He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, Ryan SJ, Oliver N, Hinton DR
    Invest. Ophthalmol. Vis. Sci., 2008;49(9):4078-88.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: In Vivo
  114. Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice.
    Authors: Jiang M, Bujo H, Ohwaki K, Unoki H, Yamazaki H, Kanaki T, Shibasaki M, Azuma K, Harigaya K, Schneider WJ, Saito Y
    J. Clin. Invest., 2008;118(8):2733-46.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium.
    Authors: Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, Camussi G, Pegoraro L, Brizzi MF
    Blood, 2007;109(10):4264-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines.
    Authors: Li R, Maminishkis A, Wang FE, Miller SS
    Invest. Ophthalmol. Vis. Sci., 2007;48(12):5722-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Atrial-radiofrequency catheter ablation mediated targeting of mesenchymal stromal cells.
    Authors: Schweizer PA, Krause U, Becker R, Seckinger A, Bauer A, Hardt C, Eckstein V, Ho AD, Koenen M, Katus HA, Zehelein J
    Stem Cells, 2007;25(6):1546-51.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
    Authors: Ball SG, Shuttleworth CA, Kielty CM
    J. Cell Biol., 2007;177(3):489-500.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
    Authors: Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B
    Dig. Dis. Sci., 2007;52(12):3404-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF-kappaB and MAPK pathways.
    Authors: Hunter I, Nixon GF
    J. Biol. Chem., 2006;281(45):34705-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Pitavastatin attenuates the PDGF-induced LR11/uPA receptor-mediated migration of smooth muscle cells.
    Authors: Jiang M, Bujo H, Zhu Y, Yamazaki H, Hirayama S, Kanaki T, Shibasaki M, Takahashi K, Schneider WJ, Saito Y
    Biochem. Biophys. Res. Commun., 2006;348(4):1367-77.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells.
    Authors: Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A
    Blood, 2006;107(5):1896-902.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Multipotent adult progenitor cells from swine bone marrow.
    Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
    Stem Cells, 2006;24(11):2355-66.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma.
    Authors: Riggi N, Cironi L, Provero P, Suva ML, Stehle JC, Baumer K, Guillou L, Stamenkovic I
    Cancer Res., 2006;66(14):7016-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
    Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2005;203(1):35-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. In vitro differences between venous and arterial-derived smooth muscle cells: potential modulatory role of decorin.
    Authors: Wong AP, Nili N, Strauss BH
    Cardiovasc. Res., 2005;65(3):702-10.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts.
    Authors: Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J
    Arthritis Rheum., 2004;50(8):2521-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
    Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
    Am. J. Respir. Cell Mol. Biol., 2004;30(6):816-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty.
    Authors: Nili N, Cheema AN, Giordano FJ, Barolet AW, Babaei S, Hickey R, Eskandarian MR, Smeets M, Butany J, Pasterkamp G, Strauss BH
    Am. J. Pathol., 2003;163(3):869-78.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Binding Assay
  130. Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation.
    Authors: Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R
    J. Biol. Chem., 2003;278(16):14087-91.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Platelet concentrates: effects of calcium and thrombin on endothelial cell proliferation and growth factor release.
    Authors: Lacoste E, Martineau I, Gagnon G
    J. Periodontol., 2003;74(10):1498-507.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  132. Dual roles of IL-4 in lung injury and fibrosis.
    Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
    J. Immunol., 2003;170(4):2083-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis.
    Authors: Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D
    J. Immunol., 2002;169(5):2653-61.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Growth factors stimulate neointimal cells in vitro and increase the thickness of the neointima formed at the neck of porcine aneurysms treated by embolization.
    Authors: Desfaits AC, 48971, Raymond J, Muizelaar JP
    Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions, 2000;31(0):498-507.
    Species: Canine
    Sample Types: In Vivo
    Applications: In Vivo
  135. Regulation of alpha(v)beta3 and alpha5beta1 integrin receptors by basic fibroblast growth factor and platelet-derived growth factor-BB in intrasynovial flexor tendon cells.
    Authors: Harwood FL, Goomer RS, Gelberman RH, Silva MJ, Amiel D
    Wound Repair Regen, 1999;7(5):381-8.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.
    Authors: Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM
    Cancer Res., 1998;58(17):4008-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. Can Recombinant Human PDGF-BB Protein, CF (Catalog # 220-BB) be reconstituted in a buffer containing BSA?

    • BSA preparations may contain minor impurities that can impact assay results, and assays involving Recombinant Human PDGF-BB Protein, CF (Catalog # 220-BB) can be influenced by these minor impurities. For this reason, we recommend reconstituting 220-BB to 100 ug/mL in 4 mM HCl. Including BSA in a buffer may be beneficial when diluting proteins to working concentrations less than 10 ug/mL. If BSA is included in an experiment involving 220-BB, we would recommend running a BSA-only control.

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Recombinant Human PDGF-BB Protein, CF
By Anonymous on 06/09/2021
Application: Immunoassay Standard

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 10/19/2019
Application: In vitro bioactivity in cell culture

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 10/09/2019
Application: CellProlif
Reason for Rating: This was a great control for my cell assay. What a reliable product.

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 05/20/2019
Application: In vitro bioactivity in cell culture

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 07/15/2018
Application: In vitro bioactivity in cell culture

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 02/12/2018
Application: Proof concept for delivery as therapeutic in a controlled delivery system
Reason for Rating: Great for proof of concept, will see how it performs in a biological assay

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 02/07/2018
Application: SDS-PAGE Control

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 09/11/2017
Application: CellProlif

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 09/07/2017
Application: Stem/Immune cell maintenance or differentiation

Recombinant Human PDGF-BB Protein, CF
By Anonymous on 07/22/2016
Application: Stem/Immune cell maintenance or differentiation