Recombinant Human SCF Protein

Newer Version Available: 7466-SC
A New rh SCF is Now Available! It has a lower endotoxin specification and is human cell expressed!
Formulations:
Catalog # Availability Size / Price Qty
255-SC-010
255-SC-050
255-SC-200
255-SC-01M
Recombinant Human SCF Protein Bioactivity
2 Images
Product Details
Citations (128)
FAQs
Supplemental Products
Reviews (2)

Recombinant Human SCF Protein Summary

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 1‑5 ng/mL.
The specific activity of Recombinant Human SCF is approximately 564 IU/μg, which is calibrated against recombinant human SCF WHO International Standard (NIBSC code: 91/682).
Source
E. coli-derived human SCF/c-kit Ligand protein
Glu26-Ala189, with an N-terminal Met
Accession #
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
18.6 kDa

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

255-SC

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

255-SC/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100-200 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity Bioactivity View Larger

Recombinant Human SCF/c-kit Ligand (Catalog # 255-SC) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 1-5 ng/mL.

SDS-PAGE SDS-PAGE View Larger

1 μg/lane of Recombinant Human SCF/c-kit Ligand was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: SCF/c-kit Ligand

Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28‑40 kDa type I transmembrane glycoprotein (1). It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1‑7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). Mature human SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail (9). The ECD shows both N‑linked and O-linked glycosylation (10). Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice (11, 12). An alternately spliced isoform of human SCF lacks 28 aa that encompasses the primary proteolytic recognition site (13). Within the ECD of the long isoform (corresponding to this recombinant protein), human SCF shares 79%‑87% aa sequence identity with canine, feline, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (9). Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c‑kit to trigger receptor dimerization and signaling (14). SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (15).

References
  1. Ashman, L.K. (1999) Int. J. Biochem. Cell Biol. 31:1037. 
  2. Sette, C. et al. (2000) Int. J. Dev. Biol. 44:599. 
  3. Yoshida, H. et al. (2001) J. Invest. Dermatol. Symp. Proc. 6:1. 
  4. Erlandsson, A. et al. (2004) Exp. Cell Res. 301:201. 
  5. Kapur, R. et al. (2002) Blood 100:1287. 
  6. Wang, C.-H. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:540. 
  7. Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 
  8. Reber, L. et al. (2006) Eur. J. Pharmacol. 533:327.
  9. Martin, F.H. et al. (1990) Cell 63:203.
  10. Arakawa, T. et al. (1991) J. Biol. Chem. 266:18942.
  11. Majumdar, M.K. et al. (1994) J. Biol. Chem. 269:1237.
  12. Brannan, C.I. et al. (1991) Proc. Natl. Acad. Sci. 88:4671.
  13. Anderson, D.M. et al. (1991) Cell Growth Differ. 2:373.
  14. Lemmon, M.A. et al. (1997) J. Biol. Chem. 272:6311.
  15. Kanellakis, P. et al. (2006) Cardiovasc. Res. 70:117.
Long Name
Stem Cell Factor
Entrez Gene IDs
4254 (Human); 17311 (Mouse); 60427 (Rat); 403507 (Canine); 493937 (Feline)
Alternate Names
c-kit Ligand; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; KIT ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SLF; steel factor

Citations for Recombinant Human SCF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

128 Citations: Showing 1 - 10
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  1. An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling
    Authors: P Potirat, M Wattanapan, V Viprakasit, P Kheolamai, S Issaragris
    Stem Cell Res, 2019;34(0):101344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production
    Authors: A Tobío, G Bandara, DA Morris, DK Kim, MP O'Connell, HD Komarow, MC Carter, D Smrz, DD Metcalfe, A Olivera
    Haematologica, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
    Authors: H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta
    Cell Stem Cell, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids
    Authors: AK Seneviratn, M Xu, JJA Henao, VA Fajardo, Z Hao, V Voisin, GW Xu, R Hurren, S Kim, N MacLean, X Wang, M Gronda, D Jeyaraju, Y Jitkova, T Ketela, M Mullokando, D Sharon, G Thomas, R Chouinard-, JR Hawley, C Schafer, HL Yau, Z Khuchua, A Aman, R Al-Awar, A Gross, SM Claypool, R Bazinet, M Lupien, S Chan, DD De Carvalh, MD Minden, GD Bader, KD Stark, P LeBlanc, AD Schimmer
    Cell Stem Cell, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
    Authors: T Hochdörfer, C Winkler, K Pardali, J Mjösberg
    Eur. J. Immunol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I
    Authors: M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue
    Stem Cell Res, 2019;36(0):101406.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2
    Authors: N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, S Demirci, JJ Haro-Mora, A Leonard, MM Hsieh, JF Tisdale
    Mol Ther Methods Clin Dev, 2019;13(0):187-196.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale
    Authors: X Wang, T Liao, C Wan, X Yang, J Zhao, R Fu, Z Yao, Y Huang, Y Shi, G Chang, Y Zheng, F Luo, Z Liu, Y Wang, X Mao, XY Zhao
    PeerJ, 2019;6(0):e6143.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment
    Authors: S Kotha, S Sun, A Adams, B Hayes, KT Phong, R Nagao, JA Reems, D Gao, B Torok-Stor, JA López, Y Zheng
    PLoS ONE, 2018;13(4):e0195082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. The effects of plasma gelsolin on human erythroblast maturation for erythrocyte production
    Authors: SY Han, EM Lee, HS Choi, BH Chun, EJ Baek
    Stem Cell Res, 2018;29(0):64-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Ceramic Hollow Fibre Constructs for Continuous Perfusion and Cell Harvest from 3D Hematopoietic Organoids
    Authors: MC Allenby, A Tahlawi, JCF Morais, K Li, N Panoskalts, A Mantalaris
    Stem Cells Int, 2018;2018(0):6230214.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response
    Authors: N Ueda, Y Uemura, R Zhang, S Kitayama, S Iriguchi, Y Kawai, Y Yasui, M Tatsumi, T Ueda, TY Liu, Y Mizoro, C Okada, A Watanabe, M Nakanishi, S Senju, Y Nishimura, K Kuzushima, H Kiyoi, T Naoe, S Kaneko
    Stem Cell Reports, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. STK3 is a therapeutic target for a subset of acute myeloid leukemias
    Authors: A Camgoz, M Paszkowski, S Satpathy, M Wermke, MV Hamann, M von Bonin, C Choudhary, S Knapp, F Buchholz
    Oncotarget, 2018;9(39):25458-25473.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
    Authors: A Minagawa, T Yoshikawa, M Yasukawa, A Hotta, M Kunitomo, S Iriguchi, M Takiguchi, Y Kassai, E Imai, Y Yasui, Y Kawai, R Zhang, Y Uemura, H Miyoshi, M Nakanishi, A Watanabe, A Hayashi, K Kawana, T Fujii, T Nakatsura, S Kaneko
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development
    Authors: M Cesana, MH Guo, D Cacchiarel, L Wahlster, J Barragan, S Doulatov, LT Vo, B Salvatori, C Trapnell, K Clement, P Cahan, KM Tsanov, PM Sousa, B Tazon-Vega, A Bolondi, FM Giorgi, A Califano, JL Rinn, A Meissner, JN Hirschhorn, GQ Daley
    Cell Stem Cell, 2018;22(4):575-588.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Optimization of an erythroid culture system to reduce the cost of in vitro production of red blood cells
    Authors: S Poldee, C Metheetrai, S Nugoolsuks, J Frayne, K Trakarnsan
    MethodsX, 2018;5(0):1626-1632.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments
    Authors: S Radecke, K Schwarz, F Radecke
    Mol. Ther., 2018;26(1):115-131.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model
    Authors: K Schmitt, P Charlins, M Veselinovi, L Kinner-Bib, S Hu, J Curlin, L Remling-Mu, KE Olson, T Aboellail, R Akkina
    Virology, 2018;515(0):235-242.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma
    Authors: P Shen, S Yang, H Sun, G Li, B Wu, F Ji, T Sun, D Zhou
    Int J Mol Sci, 2018;19(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia
    Authors: AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease
    Authors: J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin
    Mol Ther Methods Clin Dev, 2017;5(0):241-258.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Stem Cell Factor-Induced AKT Cell Signaling Pathway: Effects on Porcine Trophectoderm and Uterine Luminal Epithelial Cells
    Authors: W Jeong, S Jung, FW Bazer, J Kim
    Gen. Comp. Endocrinol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
    Authors: K Trakarnsan, RE Griffiths, MC Wilson, A Blair, TJ Satchwell, M Meinders, N Cogan, S Kupzig, R Kurita, Y Nakamura, AM Toye, DJ Anstee, J Frayne
    Nat Commun, 2017;8(0):14750.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens
    Authors: I Baccelli, J Krosl, G Boucher, I Boivin, VP Lavallée, J Hébert, S Lemieux, A Marinier, G Sauvageau
    Blood Cancer J, 2017;7(2):e529.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Anti-KIT Monoclonal Antibody Treatment Enhances the Anti-Tumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression
    Authors: AJ Garton, S Seibel, L Lopresti-M, L Crew, N Janson, S Mandiyan, ES Trombetta, S Pankratz, TM LaVallee, R Gedrich
    Mol. Cancer Ther, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)
    Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
    Stem Cell Res, 2017;21(0):19-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise
    Authors: H Zhao, S Gulesseria, MC Malinao, S Kumar-Gane, J Song, MS Chang, MM Williams, Z Zeng, M Mattie, BA Mendelsohn, DR Stover, F Doñate
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells
    Authors: M Carretta, AZ Brouwers-V, M Bosman, SJ Horton, JHA Martens, E Vellenga, JJ Schuringa
    PLoS ONE, 2017;12(12):e0189102.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Generation of human iPSCs from an essential thrombocythemia patient carrying a V501L mutation in the MPL gene
    Authors: S Liu, Z Ye, Y Gao, C He, DW Williams, A Moliterno, J Spivak, H Huang, L Cheng
    Stem Cell Res, 2017;18(0):57-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis
    Authors: L Butcher, M Ahluwalia, T Örd, J Johnston, RH Morris, E Kiss-Toth, T Örd, JD Erusalimsk
    Sci Rep, 2017;7(1):6684.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation
    Authors: YE Bar-Ephrai, F Cornelisse, N Papazian, T Konijn, RM Hoogenboez, MA Sanders, BA Westerman, M Gönültas, J Kwekkeboom, JMM Den Haan, RM Reijmers, RE Mebius, T Cupedo
    Cell Rep, 2017;21(3):823-833.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors
    Authors: J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou
    Cell Rep, 2017;20(3):529-537.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
    Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
    Cell Rep, 2017;20(7):1597-1608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Identifying residues that determine SCF molecular-level interactions through a combination of experimental and in silico analyses
    J. Mol. Biol., 2016;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  35. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
    Authors: Ivan Carcamo-Or
    Cell Stem Cell, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta
    Authors: Amber N Stratman
    Development, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Efficient regeneration of Human V?24(+) invariant NKT cells and their anti-tumor activity in vivo
    Stem Cells, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes
    Immunology, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway
    Cell Biosci, 2016;6(1):50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts
    Blood, 2016;127(23):2879-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML
    Mol Ther Methods Clin Dev, 2016;3(0):16074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells
    Stem Cell Res, 2016;17(2):296-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus)
    Authors: Thomas Müller
    Transfusion, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer.
    Authors: Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, Geller M, Kaufman D
    Stem Cells, 2016;34(1):93-101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease
    JCI Insight, 2016;1(20):e87446.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Effect of high-dose plerixafor on CD34+ cells mobilization in healthy stem-cell donors: results of a randomized crossover trial
    Haematologica, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells
    Nature, 2016;532(7600):508-11.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML).
    Authors: Jiang X, Lim C, Li Z, Lee P, Yatim S, Guan P, Li J, Zhou J, Pan J, Chng W, Chai C, Yu Q
    PLoS ONE, 2015;10(4):e0122983.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells.
    Authors: Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M
    Stem Cells, 2015;33(4):1142-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
    Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
    PLoS ONE, 2015;10(3):e0122149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha or malarial pigment.
    Authors: Lamikanra A, Merryweather-Clarke A, Tipping A, Roberts D
    PLoS ONE, 2015;10(3):e0119836.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques.
    Authors: Barese C, Felizardo T, Sellers S, Keyvanfar K, Di Stasi A, Metzger M, Krouse A, Donahue R, Spencer D, Dunbar C
    Stem Cells, 2015;33(1):91-100.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Transcriptome analysis of Kaposi's sarcoma-associated herpesvirus during de novo primary infection of human B and endothelial cells.
    Authors: Purushothaman P, Thakker S, Verma S
    J Virol, 2015;89(6):3093-111.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Small-molecule inhibitor of glycogen synthase kinase 3beta 6-Bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice.
    Authors: Shen S, Xu N, Klamer G, Ko K, Khoo M, Ma D, Moore J, O'Brien T, Dolnikov A
    Stem Cells Dev, 2015;24(6):724-36.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system.
    Authors: Song B, Fan Y, He W, Zhu D, Niu X, Wang D, Ou Z, Luo M, Sun X
    Stem Cells Dev, 2015;24(9):1053-65.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. GSK3beta inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.
    Authors: Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito M, Toyoda M, Umezawa A, Hara T
    Exp Hematol, 2015;44(1):68-74.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-beta1 alleviate atopic dermatitis by reducing mast cell degranulation.
    Authors: Kim H, Yun J, Shin T, Lee S, Lee B, Yu K, Seo Y, Lee S, Kang T, Choi S, Seo K, Kang K
    Stem Cells, 2015;33(4):1254-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Epigenetic reprogramming induces the expansion of cord blood stem cells.
    Authors: Chaurasia P, Gajzer D, Schaniel C, D'Souza S, Hoffman R
    J Clin Invest, 2014;124(6):2378-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment.
    Authors: Horwitz, Mitchell, Chao, Nelson J, Rizzieri, David A, Long, Gwynn D, Sullivan, Keith M, Gasparetto, Cristina, Chute, John P, Morris, Ashley, McDonald, Carolyn, Waters-Pick, Barbara, Stiff, Patrick, Wease, Steven, Peled, Amnon, Snyder, David, Cohen, Einat Ga, Shoham, Hadas, Landau, Efrat, Friend, Etty, Peleg, Iddo, Aschengrau, Dorit, Yackoubov, Dima, Kurtzberg, Joanne, Peled, Tony
    J Clin Invest, 2014;124(7):3121-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells.
    Authors: Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L
    J Leukoc Biol, 2014;95(6):893-901.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.
    Authors: Wu C, Li B, Lu R, Koelle S, Yang Y, Jares A, Krouse A, Metzger M, Liang F, Lore K, Wu C, Donahue R, Chen I, Weissman I, Dunbar C
    Cell Stem Cell, 2014;14(4):486-99.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
    Authors: Reynolds, C, Roderick, J E, LaBelle, J L, Bird, G, Mathieu, R, Bodaar, K, Colon, D, Pyati, U, Stevenson, K E, Qi, J, Harris, M, Silverman, L B, Sallan, S E, Bradner, J E, Neuberg, D S, Look, A T, Walensky, L D, Kelliher, M A, Gutierrez, A
    Leukemia, 2014;28(9):1819-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.
    Authors: Morishima, Tatsuya, Watanabe, Ken-ichi, Niwa, Akira, Hirai, Hideyo, Saida, Satoshi, Tanaka, Takayuki, Kato, Itaru, Umeda, Katsutsu, Hiramatsu, Hidefumi, Saito, Megumu K, Matsubara, Kousaku, Adachi, Souichi, Kobayashi, Masao, Nakahata, Tatsutos, Heike, Toshio
    Haematologica, 2014;99(1):19-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling.
    Authors: Csaszar, Elizabet, Wang, Weijia, Usenko, Tatiana, Qiao, Wenlian, Delaney, Colleen, Bernstein, Irwin D, Zandstra, Peter W
    Blood, 2014;123(5):650-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells.
    Authors: Khoo M, Carlin S, Lutherborrow M, Jayaswal V, Ma D, Moore J
    Aging Cell, 2014;13(4):744-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Gene transfer properties and structural modeling of human stem cell-derived AAV.
    Authors: Smith, Laura J, Ul-Hasan, Taihra, Carvaines, Sarah K, Van Vliet, Kim, Yang, Ethel, Wong, Kamehame, Agbandje-McKenna, Mavis, Chatterjee, Saswati
    Mol Ther, 2014;22(9):1625-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
    Authors: Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K
    Cell Stem Cell, 2014;14(4):535-48.
  68. Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.
    Authors: Kazuki, Yasuhiro, Yakura, Yuwna, Abe, Satoshi, Osaki, Mitsuhik, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Honma, Kazuhisa, Suemori, Hirofumi, Yamazaki, Satoshi, Sakuma, Tetsushi, Toki, Tsutomu, Shimizu, Ritsuko, Nakauchi, Hiromits, Yamamoto, Takashi, Oshimura, Mitsuo
    Sci Rep, 2014;4(0):6136.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia.
    Authors: Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C
    Blood, 2014;123(20):3116-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny.
    Authors: Muench M, Beyer A, Fomin M, Thakker R, Mulvaney U, Nakamura M, Suemizu H, Barcena A
    PLoS ONE, 2014;9(5):e97312.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP).
    Authors: Rosen, David B, Leung, Ling Y, Louie, Brent, Cordeiro, James A, Conroy, Andrew, Shapira, Iuliana, Fields, Scott Z, Cesano, Alessand, Hawtin, Rachael
    J Transl Med, 2014;12(0):184.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Evaluation of engraftment and immunological tolerance after reduced intensity conditioning in a rhesus hematopoietic stem cell gene therapy model.
    Authors: Uchida N, Weitzel R, Evans M, Green R, Bonifacino A, Krouse A, Metzger M, Hsieh M, Donahue R, Tisdale J
    Gene Ther, 2014;21(2):148-57.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  73. The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma.
    Authors: Todd J, Scurr L, Becker T, Kefford R, Rizos H
    Oncogene, 2014;33(2):236-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector.
    Authors: Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou M, Chan J
    PLoS ONE, 2014;9(8):e104805.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.
    Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
    J Invest Dermatol, 2014;134(5):1246-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. BCR-ABL-induced deregulation of the IL-33/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients.
    Authors: Levescot A, Flamant S, Basbous S, Jacomet F, Feraud O, Anne Bourgeois E, Bonnet M, Giraud C, Roy L, Barra A, Chomel J, Turhan A, Guilhot F, Girard J, Gombert J, Herbelin A
    Cancer Res, 2014;74(10):2669-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells.
    Authors: Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S
    Stem Cells, 2014;32(5):1337-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
    Authors: Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J
    Blood, 2014;123(8):1239-49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value.
    Authors: Vannucchi, A M, Rotunno, G, Bartalucci, N, Raugei, G, Carrai, V, Balliu, M, Mannarelli, C, Pacilli, A, Calabresi, L, Fjerza, R, Pieri, L, Bosi, A, Manfredini, R, Guglielmelli, P
    Leukemia, 2014;28(9):1811-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity.
    Authors: Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Wang, Xiaoming, Goard, Carolyn, Jhas, Bozhena, Schimmer, Aaron D
    PLoS ONE, 2014;9(5):e95281.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
    Authors: Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G
    Cell Stem Cell, 2013;13(4):459-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
    Authors: Smith A, Bowers S, Stratman A, Davis G
    PLoS ONE, 2013;8(12):e85147.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. beta-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model.
    Authors: Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C
    PLoS ONE, 2013;8(11):e80403.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
    Authors: Yu, Jianhua, Peng, Yong, Wu, Lai-Chu, Xie, Zhiliang, Deng, Youcai, Hughes, Tiffany, He, Shun, Mo, XiaoKui, Chiu, Ming, Wang, Qi-En, He, Xiaoming, Liu, Shujun, Grever, Michael, Chan, Kenneth, Liu, Zhongfa
    PLoS ONE, 2013;8(2):e55934.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples.
    Authors: Bachet J, Tabone-Eglinger S, Dessaux S, Besse A, Brahimi-Adouane S, Emile J, Blay J, Alberti L
    PLoS ONE, 2013;8(4):e61103.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14.
    Authors: Farrer R, Farrer J, DeVries G
    J Biol Chem, 2013;288(16):11066-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells.
    Authors: Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D
    Mol Ther, 2013;21(5):1044-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming.
    Authors: Lee M, Prasain N, Chae H, Kim Y, Mantel C, Yoder M, Broxmeyer H
    Stem Cells, 2013;31(4):666-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms.
    Blood Cancer J, 2012;2(0):e87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
    Gene Ther, 2012;19(10):1035-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene.
    Authors: Li Q, Ramirez-Bergeron D, Dunwoodie S, Yang Y
    J Biol Chem, 2012;287(34):29088-100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells.
    Authors: Ichii, Michiko, Frank, Mark Bar, Iozzo, Renato V, Kincade, Paul W
    Blood, 2012;119(7):1683-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
    BMC Cancer, 2012;12(0):431.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor.
    Authors: Torrano V, Procter J, Cardus P
    Blood, 2011;118(18):4910-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.
    Authors: Niwa A, Heike T, Umeda K
    PLoS ONE, 2011;6(7):e22261.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
    Authors: Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B
    Blood, 2011;117(3):839-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Optimal conditions for lentiviral transduction of engrafting human CD34+ cells.
    Authors: Uchida N, Hsieh MM, Hayakawa J, Madison C, Washington KN, Tisdale JF
    Gene Ther., 2011;18(11):1078-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Dynamic interaction networks in a hierarchically organized tissue.
    Authors: Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW
    Mol. Syst. Biol., 2010;6(0):417.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
    Authors: Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE
    Blood, 2009;114(24):5091-101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses.
    Authors: Duraisingham SS, Hornig J, Gotch F, Patterson S
    J. Immunol., 2009;183(4):2242-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice.
    Authors: Margulis A, Nocka KH, Wood NL, Wolf SF, Goldman SJ, Kasaian MT
    Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(2):L236-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.
    Authors: Aerbajinai W, Zhu J, Kumkhaek C, Chin K, Rodgers GP
    Blood, 2009;114(1):187-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.
    Authors: Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT
    J. Immunol., 2009;183(3):1739-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
    Authors: Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(24):9826-30.
  105. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
    Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
    Exp. Hematol., 2008;36(8):1035-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions.
    Authors: Gunetti M, Ferrero I, Rustichelli D, Berger M, Gammaitoni L, Timeus F, Piacibello W, Aglietta M, Fagioli F
    Exp. Hematol., 2008;36(2):235-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells.
    Authors: Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J
    Exp. Hematol., 2008;36(9):1121-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.
    Authors: Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P
    J. Immunol., 2008;181(4):2772-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15.
    Authors: McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS
    Exp. Hematol., 2008;36(5):598-608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis.
    Authors: Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, Feghali-Bostwick CA, Silver RM
    Arthritis Rheum., 2007;56(7):2432-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium.
    Authors: Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, Camussi G, Pegoraro L, Brizzi MF
    Blood, 2007;109(10):4264-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts.
    Authors: Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U
    Stem Cells, 2007;25(8):1862-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells.
    Authors: Srivastava AS, Nedelcu E, Esmaeli-Azad B, Mishra R, Carrier E
    Stem Cells, 2007;25(6):1456-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector.
    Authors: Kahl CA, Tarantal AF, Lee CI, Jimenez DF, Choi C, Pepper K, Petersen D, Fletcher MD, Leapley AC, Fisher J, Burns TS, Ultsch MN, Dorey FJ, Kohn DB
    Exp. Hematol., 2006;34(3):369-81.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells.
    Authors: Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, Zini R, Salati S, Tagliafico E, Manfredini R, Grande A, Ferrari S
    Cell Death Differ., 2006;13(10):1686-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Isolation of a novel population of multipotent adult stem cells from human hair follicles.
    Authors: Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X
    Am. J. Pathol., 2006;168(6):1879-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells.
    Authors: Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y
    Exp. Hematol., 2006;34(6):760-9.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Growth hormone-induced stimulation of multilineage human hematopoiesis.
    Authors: Hanley MB, Napolitano LA, McCune JM
    Stem Cells, 2005;23(8):1170-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells.
    Authors: Hsieh FH, Sharma P, Gibbons A, Goggans T, Erzurum SC, Haque SJ
    Proc. Natl. Acad. Sci. U.S.A., 2005;102(40):14380-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Establishment and characterization of continuous hematopoietic progenitors-derived pig normal mast cell lines.
    Authors: Femenia F, Arock M, Leriche L, Delouis C, Millet G, Ben Hamouda N, Cote M, Alliot A, Lilin T, Pinton A, Iannucceli N, Parodi AL, Boireau P
    Life Sci., 2005;77(7):808-23.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Growth differentiation factor-9 and stem cell factor promote primordial follicle formation in the hamster: modulation by follicle-stimulating hormone.
    Authors: Wang J, Roy SK
    Biol. Reprod., 2004;70(3):577-85.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCF.
    Authors: Da Silva CA, 2019, Kassel O, Mathieu E, Massard G, Gasser B, Frossard N
    , 2002;135(7):1634-40.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  123. Prospective isolation of human clonogenic common myeloid progenitors.
    Authors: Manz MG, Miyamoto T, Akashi K, Weissman IL
    Proc. Natl. Acad. Sci. U.S.A., 2002;99(18):11872-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
    Authors: Shih CC, Hu MC, Hu J
    Blood, 2000;95(6):1957-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model.
    Authors: Gomez-Navarro J, Contreras JL, Arafat W, Jiang XL, Krisky D, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM
    Gene Ther., 2000;7(1):43-52.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  126. The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation.
    Authors: Drouet M, 49153, Mathieu J, Grenier N, Multon E, Sotto JJ, Herodin F
    Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance, 1999;17(5):273-85.
    Species: Primate - Papio anubis (Olive Baboon)
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.
    Authors: Barcena A, Park SW, Banapour B, Muench MO, Mechetner E
    Blood, 1996;88(6):2013-25.
    Species: Human
    Sample Types:
    Applications: Bioassay
  128. Defining human dendritic cell progenitors by multiparametric flow cytometry.
    Authors: Breton G, Lee J, Liu K, Nussenzweig M
    Nat Protoc, 0;10(9):1407-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Human SCF Protein
By Anonymous on 03/28/2018
Application: Binding assay/Protein-protein interaction

Recombinant Human SCF Protein
By Anonymous on 12/15/2016
Application: Stem/Immune cell maintenance or differentiation

I used iPSCs to produce red blood cell using SCF for differentiation.