Recombinant Human SCF Protein

Newer Version Available: 7466-SC/CF
A New rh SCF is Now Available! It has a lower endotoxin specification and is human cell expressed!

Carrier Free

Catalog # Availability Size / Price Qty
255-SC-001MG/CF
255-SC-010/CF
255-SC-050/CF
255-SC-200/CF

With Carrier

Catalog # Availability Size / Price Qty
255-SC-010
255-SC-050
255-SC-200
255-SC-01M
Recombinant Human SCF Protein Bioactivity
2 Images
Product Details
Citations (149)
FAQs
Supplemental Products
Reviews (5)

Recombinant Human SCF Protein Summary

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 1‑5 ng/mL.
The specific activity of Recombinant Human SCF is approximately 564 IU/μg, which is calibrated against recombinant human SCF WHO International Standard (NIBSC code: 91/682).
Source
E. coli-derived human SCF/c-kit Ligand protein
Glu26-Ala189, with an N-terminal Met
Accession #
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
18.6 kDa
SDS-PAGE
17-18 kDa, under reducing condtitions

Product Datasheets

255-SC (with carrier)

255-SC/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

255-SC

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

255-SC/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100-200 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity Recombinant Human SCF Protein Bioactivity View Larger

Recombinant Human SCF/c-kit Ligand (Catalog # 255-SC) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50for this effect is 1-5 ng/mL.

SDS-PAGE Recombinant Human SCF Protein SDS-PAGE View Larger

2 μg/lane of Recombinant Human SCF/c-kit Ligand was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions visualized by Coomassie® Blue staining, showing bands at 17-18 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: SCF/c-kit Ligand

What is Stem cell factor?

Stem cell factor (SCF) is a potent hematopoietic growth factor required in regulating both embryonic and adult hematopoiesis. SCF protein promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1 7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). And SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (9). Stem cell factor is an important cytokine for ex vivo clinical applications. Along with other cytokines, SCF is used in the culture and expansion of hematopoietic stem cells (HSCs) as well as for proliferation and differentiation of both myeloid and erythroid progenitor cells.

Mature stem cell factor consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane domain, and a 36 aa cytoplasmic tail (10). The ECD shows both N linked and O-linked glycosylation (11). SCF protein exists in two forms, a membrane-bound form and a proteolytically processed soluble form that lacks the transmembrane domain and cytoplasmic tail. The soluble form is created by proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releasing a 25 kDa soluble SCF protein which is comparable to the only form produced by Steel-dickie mutant mice (12, 13). There is also an alternately spliced isoform of human SCF that lacks 28 amino acids that encompasses the primary proteolytic recognition site (14). This form cannot be cleaved and is only membrane bound.

SCF binds to C-kit (CD117). C-kit is expressed on many different cell types including HSCs, mast cells, germ cells, and melanocytes. Binding of SCF to C-kit induces receptor dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain (15). Tyrosine phosphorylation initiates multiple signaling pathways including RAS, PI3 kinase, Src, and JAK/STAT. Stem cell factor is highly conserved among mammals. Human SCF protein shares 79% 87% aa sequence identity with dog, cat, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (10).

References
  1. Ashman, L.K. (1999) Int. J. Biochem. Cell Biol. 31:1037. 
  2. Sette, C. et al. (2000) Int. J. Dev. Biol. 44:599. 
  3. Yoshida, H. et al. (2001) J. Invest. Dermatol. Symp. Proc. 6:1. 
  4. Erlandsson, A. et al. (2004) Exp. Cell Res. 301:201. 
  5. Kapur, R. et al. (2002) Blood 100:1287. 
  6. Wang, C.-H. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:540. 
  7. Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 
  8. Reber, L. et al. (2006) Eur. J. Pharmacol. 533:327.
  9. Kanellakis, P. et al. (2006) Cardiovasc. Res. 70:117.
  10. Martin, F.H. et al. (1990) Cell 63:203.
  11. Arakawa, T. et al. (1991) J. Biol. Chem. 266:18942.
  12. Majumdar, M.K. et al. (1994) J. Biol. Chem. 269:1237.
  13. Brannan, C.I. et al. (1991) Proc. Natl. Acad. Sci. 88:4671.
  14. Anderson, D.M. et al. (1991) Cell Growth Differ. 2:373.
  15. Lemmon, M.A. et al. (1997) J. Biol. Chem. 272:6311.
Long Name
Stem Cell Factor
Entrez Gene IDs
4254 (Human); 17311 (Mouse); 60427 (Rat); 403507 (Canine); 493937 (Feline)
Alternate Names
c-kit Ligand; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; KIT ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SHEP7; SLF; steel factor

Citations for Recombinant Human SCF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

149 Citations: Showing 1 - 10
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  1. Generation of human oogonia from induced pluripotent stem cells in culture
    Authors: C Yamashiro, K Sasaki, S Yokobayash, Y Kojima, M Saitou
    Nat Protoc, 2020;15(4):1560-1583.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells
    Authors: J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou
    Cell Rep, 2020;31(9):107688.
    Species: Human
    Sample Types: Whole Cell
    Applications: Cell Culture
  3. &betaT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex�Vivo Anti-sickling Activity in Human Erythroid Cells
    Authors: S Demirci, B Gudmundsdo, Q Li, JJ Haro-Mora, T Nassehi, C Drysdale, M Yapundich, J Gamer, F Seifuddin, JF Tisdale, N Uchida
    Mol Ther Methods Clin Dev, 2020;17(0):912-921.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. Generation and characterization of HLA-universal platelets derived from induced pluripotent stem cells
    Authors: P Norbnop, P Ingrungrua, N Israsena, K Suphapeeti, V Shotelersu
    Sci Rep, 2020;10(1):8472.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  5. An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling
    Authors: P Potirat, M Wattanapan, V Viprakasit, P Kheolamai, S Issaragris
    Stem Cell Res, 2019;34(0):101344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders
    Authors: N Uchida, MM Hsieh, L Raines, JJ Haro-Mora, S Demirci, AC Bonifacino, AE Krouse, ME Metzger, RE Donahue, JF Tisdale
    Nat Commun, 2019;10(1):4479.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
    Authors: WR Proto, SV Siegel, S Dankwa, W Liu, A Kemp, S Marsden, ZA Zenonos, S Unwin, PM Sharp, GJ Wright, BH Hahn, MT Duraisingh, JC Rayner
    Nat Commun, 2019;10(1):4512.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. Homologous Recombination-Based Genome Editing by Clade F AAVs Is Inefficient in the Absence of a Targeted DNA Break
    Authors: GL Rogers, HY Chen, H Morales, PM Cannon
    Mol. Ther., 2019;27(10):1726-1736.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Diminished AHR signaling drives human acute myeloid leukemia stem cell maintenance
    Authors: M Ly, S Rentas, A Vujovic, N Wong, S Moreira, J Xu, N Holzapfel, S Bhatia, D Tran, MD Minden, JS Draper, KJ Hope
    Cancer Res., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients
    Authors: M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa
    Haematologica, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
    Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
    Cell Rep, 2019;27(2):599-615.e12.
    Species: Human
    Sample Types: cell culture
    Applications: Differentiation
  12. Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
    Authors: H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta
    Cell Stem Cell, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production
    Authors: A Tobío, G Bandara, DA Morris, DK Kim, MP O'Connell, HD Komarow, MC Carter, D Smrz, DD Metcalfe, A Olivera
    Haematologica, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. A systems biology pipeline identifies regulatory networks for stem cell engineering
    Authors: MA Kinney, LT Vo, JM Frame, J Barragan, AJ Conway, S Li, KK Wong, JJ Collins, P Cahan, TE North, DA Lauffenbur, GQ Daley
    Nat. Biotechnol., 2019;37(7):810-818.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  15. The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids
    Authors: AK Seneviratn, M Xu, JJA Henao, VA Fajardo, Z Hao, V Voisin, GW Xu, R Hurren, S Kim, N MacLean, X Wang, M Gronda, D Jeyaraju, Y Jitkova, T Ketela, M Mullokando, D Sharon, G Thomas, R Chouinard-, JR Hawley, C Schafer, HL Yau, Z Khuchua, A Aman, R Al-Awar, A Gross, SM Claypool, R Bazinet, M Lupien, S Chan, DD De Carvalh, MD Minden, GD Bader, KD Stark, P LeBlanc, AD Schimmer
    Cell Stem Cell, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
    Authors: T Hochdörfer, C Winkler, K Pardali, J Mjösberg
    Eur. J. Immunol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I
    Authors: M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue
    Stem Cell Res, 2019;36(0):101406.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2
    Authors: N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, S Demirci, JJ Haro-Mora, A Leonard, MM Hsieh, JF Tisdale
    Mol Ther Methods Clin Dev, 2019;13(0):187-196.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale
    Authors: X Wang, T Liao, C Wan, X Yang, J Zhao, R Fu, Z Yao, Y Huang, Y Shi, G Chang, Y Zheng, F Luo, Z Liu, Y Wang, X Mao, XY Zhao
    PeerJ, 2019;6(0):e6143.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
    Authors: J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen
    Nat Commun, 2019;10(1):4856.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
    Authors: MD McKenzie, M Ghisi, EP Oxley, S Ngo, L Cimmino, C Esnault, R Liu, JM Salmon, CC Bell, N Ahmed, M Erlichster, MT Witkowski, GJ Liu, M Chopin, A Dakic, E Simankowic, G Pomilio, T Vu, P Krsmanovic, S Su, L Tian, TM Baldwin, DA Zalcenstei, L DiRago, S Wang, D Metcalf, RW Johnstone, BA Croker, GI Lancaster, AJ Murphy, SH Naik, SL Nutt, V Pospisil, T Schroeder, M Wall, MA Dawson, AH Wei, H de Thé, ME Ritchie, J Zuber, RA Dickins
    Cell Stem Cell, 2019;25(2):258-272.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  22. UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
    Authors: J Chagraoui, B Lehnertz, S Girard, JF Spinella, I Fares, E Tomellini, N Mayotte, S Corneau, T MacRae, L Simon, G Sauvageau
    PLoS ONE, 2019;14(11):e0224900.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  23. Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system
    Authors: JP Ruiz, G Chen, JJ Haro Mora, K Keyvanfar, C Liu, J Zou, J Beers, H Bloomer, H Qanash, N Uchida, JF Tisdale, M Boehm, A Larochelle
    Stem Cell Res, 2019;41(0):101600.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  24. Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells
    Authors: Z Li, F Fang, Q Zhao, H Li, C Xiong
    Stem Cell Res Ther, 2019;10(1):324.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  25. Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells
    Authors: T Ikuno, S Ito, T Inoue
    J Toxicol Sci, 2019;44(11):789-797.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity
    Authors: D Suzuki, C Flahou, N Yoshikawa, I Stirblyte, Y Hayashi, A Sawaguchi, M Akasaka, S Nakamura, N Higashi, H Xu, T Matsumoto, K Fujio, MG Manz, A Hotta, H Takizawa, K Eto, N Sugimoto
    Stem Cell Reports, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Low-Dose Busulfan Reduces Human CD34+ Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice
    Authors: A Leonard, M Yapundich, T Nassehi, J Gamer, CM Drysdale, JJ Haro-Mora, S Demirci, MM Hsieh, N Uchida, JF Tisdale
    Mol Ther Methods Clin Dev, 2019;15(0):430-437.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Ceramic Hollow Fibre Constructs for Continuous Perfusion and Cell Harvest from 3D Hematopoietic Organoids
    Authors: MC Allenby, A Tahlawi, JCF Morais, K Li, N Panoskalts, A Mantalaris
    Stem Cells Int, 2018;2018(0):6230214.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments
    Authors: S Radecke, K Schwarz, F Radecke
    Mol. Ther., 2018;26(1):115-131.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model
    Authors: K Schmitt, P Charlins, M Veselinovi, L Kinner-Bib, S Hu, J Curlin, L Remling-Mu, KE Olson, T Aboellail, R Akkina
    Virology, 2018;515(0):235-242.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development
    Authors: M Cesana, MH Guo, D Cacchiarel, L Wahlster, J Barragan, S Doulatov, LT Vo, B Salvatori, C Trapnell, K Clement, P Cahan, KM Tsanov, PM Sousa, B Tazon-Vega, A Bolondi, FM Giorgi, A Califano, JL Rinn, A Meissner, JN Hirschhorn, GQ Daley
    Cell Stem Cell, 2018;22(4):575-588.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
    Authors: CM Ferrer, M Alders, AV Postma, S Park, MA Klein, M Cetinbas, E Pajkrt, A Glas, S van Koning, VM Christoffe, MMAM Mannens, L Knegt, JP Etchegaray, RI Sadreyev, JM Denu, G Mostoslavs, MC van Maarle, R Mostoslavs
    Genes Dev., 2018;32(5):373-388.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma
    Authors: P Shen, S Yang, H Sun, G Li, B Wu, F Ji, T Sun, D Zhou
    Int J Mol Sci, 2018;19(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
    Authors: A Minagawa, T Yoshikawa, M Yasukawa, A Hotta, M Kunitomo, S Iriguchi, M Takiguchi, Y Kassai, E Imai, Y Yasui, Y Kawai, R Zhang, Y Uemura, H Miyoshi, M Nakanishi, A Watanabe, A Hayashi, K Kawana, T Fujii, T Nakatsura, S Kaneko
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. STK3 is a therapeutic target for a subset of acute myeloid leukemias
    Authors: A Camgoz, M Paszkowski, S Satpathy, M Wermke, MV Hamann, M von Bonin, C Choudhary, S Knapp, F Buchholz
    Oncotarget, 2018;9(39):25458-25473.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. The effects of plasma gelsolin on human erythroblast maturation for erythrocyte production
    Authors: SY Han, EM Lee, HS Choi, BH Chun, EJ Baek
    Stem Cell Res, 2018;29(0):64-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment
    Authors: S Kotha, S Sun, A Adams, B Hayes, KT Phong, R Nagao, JA Reems, D Gao, B Torok-Stor, JA López, Y Zheng
    PLoS ONE, 2018;13(4):e0195082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response
    Authors: N Ueda, Y Uemura, R Zhang, S Kitayama, S Iriguchi, Y Kawai, Y Yasui, M Tatsumi, T Ueda, TY Liu, Y Mizoro, C Okada, A Watanabe, M Nakanishi, S Senju, Y Nishimura, K Kuzushima, H Kiyoi, T Naoe, S Kaneko
    Stem Cell Reports, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Optimization of an erythroid culture system to reduce the cost of in vitro production of red blood cells
    Authors: S Poldee, C Metheetrai, S Nugoolsuks, J Frayne, K Trakarnsan
    MethodsX, 2018;5(0):1626-1632.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Molecular transitions in early progenitors during human cord blood hematopoiesis
    Authors: S Zheng, E Papalexi, A Butler, W Stephenson, R Satija
    Mol. Syst. Biol., 2018;14(3):e8041.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells
    Authors: M Carretta, AZ Brouwers-V, M Bosman, SJ Horton, JHA Martens, E Vellenga, JJ Schuringa
    PLoS ONE, 2017;12(12):e0189102.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)
    Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
    Stem Cell Res, 2017;21(0):19-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Stem Cell Factor-Induced AKT Cell Signaling Pathway: Effects on Porcine Trophectoderm and Uterine Luminal Epithelial Cells
    Authors: W Jeong, S Jung, FW Bazer, J Kim
    Gen. Comp. Endocrinol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Anti-KIT Monoclonal Antibody Treatment Enhances the Anti-Tumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression
    Authors: AJ Garton, S Seibel, L Lopresti-M, L Crew, N Janson, S Mandiyan, ES Trombetta, S Pankratz, TM LaVallee, R Gedrich
    Mol. Cancer Ther, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise
    Authors: H Zhao, S Gulesseria, MC Malinao, S Kumar-Gane, J Song, MS Chang, MM Williams, Z Zeng, M Mattie, BA Mendelsohn, DR Stover, F Doñate
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens
    Authors: I Baccelli, J Krosl, G Boucher, I Boivin, VP Lavallée, J Hébert, S Lemieux, A Marinier, G Sauvageau
    Blood Cancer J, 2017;7(2):e529.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
    Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
    Cell Rep, 2017;20(7):1597-1608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Generation of human iPSCs from an essential thrombocythemia patient carrying a V501L mutation in the MPL gene
    Authors: S Liu, Z Ye, Y Gao, C He, DW Williams, A Moliterno, J Spivak, H Huang, L Cheng
    Stem Cell Res, 2017;18(0):57-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease
    Authors: J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin
    Mol Ther Methods Clin Dev, 2017;5(0):241-258.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
    Authors: K Trakarnsan, RE Griffiths, MC Wilson, A Blair, TJ Satchwell, M Meinders, N Cogan, S Kupzig, R Kurita, Y Nakamura, AM Toye, DJ Anstee, J Frayne
    Nat Commun, 2017;8(0):14750.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia
    Authors: AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors
    Authors: J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou
    Cell Rep, 2017;20(3):529-537.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation
    Authors: YE Bar-Ephrai, F Cornelisse, N Papazian, T Konijn, RM Hoogenboez, MA Sanders, BA Westerman, M Gönültas, J Kwekkeboom, JMM Den Haan, RM Reijmers, RE Mebius, T Cupedo
    Cell Rep, 2017;21(3):823-833.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis
    Authors: L Butcher, M Ahluwalia, T Örd, J Johnston, RH Morris, E Kiss-Toth, T Örd, JD Erusalimsk
    Sci Rep, 2017;7(1):6684.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway
    Cell Biosci, 2016;6(1):50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer.
    Authors: Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, Geller M, Kaufman D
    Stem Cells, 2016;34(1):93-101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
    Authors: Ivan Carcamo-Or
    Cell Stem Cell, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta
    Authors: Amber N Stratman
    Development, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Identifying residues that determine SCF molecular-level interactions through a combination of experimental and in silico analyses
    J. Mol. Biol., 2016;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  60. Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells
    Nature, 2016;532(7600):508-11.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes
    Immunology, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus)
    Authors: Thomas Müller
    Transfusion, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts
    Blood, 2016;127(23):2879-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Effect of high-dose plerixafor on CD34+ cells mobilization in healthy stem-cell donors: results of a randomized crossover trial
    Haematologica, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Efficient regeneration of Human V?24(+) invariant NKT cells and their anti-tumor activity in vivo
    Stem Cells, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells
    Stem Cell Res, 2016;17(2):296-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML
    Mol Ther Methods Clin Dev, 2016;3(0):16074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease
    JCI Insight, 2016;1(20):e87446.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha or malarial pigment.
    Authors: Lamikanra A, Merryweather-Clarke A, Tipping A, Roberts D
    PLoS ONE, 2015;10(3):e0119836.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells.
    Authors: Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M
    Stem Cells, 2015;33(4):1142-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Small-molecule inhibitor of glycogen synthase kinase 3beta 6-Bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice.
    Authors: Shen S, Xu N, Klamer G, Ko K, Khoo M, Ma D, Moore J, O'Brien T, Dolnikov A
    Stem Cells Dev, 2015;24(6):724-36.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-beta1 alleviate atopic dermatitis by reducing mast cell degranulation.
    Authors: Kim H, Yun J, Shin T, Lee S, Lee B, Yu K, Seo Y, Lee S, Kang T, Choi S, Seo K, Kang K
    Stem Cells, 2015;33(4):1254-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Transcriptome analysis of Kaposi's sarcoma-associated herpesvirus during de novo primary infection of human B and endothelial cells.
    Authors: Purushothaman P, Thakker S, Verma S
    J Virol, 2015;89(6):3093-111.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML).
    Authors: Jiang X, Lim C, Li Z, Lee P, Yatim S, Guan P, Li J, Zhou J, Pan J, Chng W, Chai C, Yu Q
    PLoS ONE, 2015;10(4):e0122983.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
    Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
    PLoS ONE, 2015;10(3):e0122149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. GSK3beta inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.
    Authors: Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito M, Toyoda M, Umezawa A, Hara T
    Exp Hematol, 2015;44(1):68-74.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system.
    Authors: Song B, Fan Y, He W, Zhu D, Niu X, Wang D, Ou Z, Luo M, Sun X
    Stem Cells Dev, 2015;24(9):1053-65.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques.
    Authors: Barese C, Felizardo T, Sellers S, Keyvanfar K, Di Stasi A, Metzger M, Krouse A, Donahue R, Spencer D, Dunbar C
    Stem Cells, 2015;33(1):91-100.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia.
    Authors: Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C
    Blood, 2014;123(20):3116-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Epigenetic reprogramming induces the expansion of cord blood stem cells.
    Authors: Chaurasia P, Gajzer D, Schaniel C, D'Souza S, Hoffman R
    J Clin Invest, 2014;124(6):2378-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
    Authors: Reynolds, C, Roderick, J E, LaBelle, J L, Bird, G, Mathieu, R, Bodaar, K, Colon, D, Pyati, U, Stevenson, K E, Qi, J, Harris, M, Silverman, L B, Sallan, S E, Bradner, J E, Neuberg, D S, Look, A T, Walensky, L D, Kelliher, M A, Gutierrez, A
    Leukemia, 2014;28(9):1819-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny.
    Authors: Muench M, Beyer A, Fomin M, Thakker R, Mulvaney U, Nakamura M, Suemizu H, Barcena A
    PLoS ONE, 2014;9(5):e97312.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
    Authors: Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K
    Cell Stem Cell, 2014;14(4):535-48.
  84. Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling.
    Authors: Csaszar, Elizabet, Wang, Weijia, Usenko, Tatiana, Qiao, Wenlian, Delaney, Colleen, Bernstein, Irwin D, Zandstra, Peter W
    Blood, 2014;123(5):650-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Gene transfer properties and structural modeling of human stem cell-derived AAV.
    Authors: Smith, Laura J, Ul-Hasan, Taihra, Carvaines, Sarah K, Van Vliet, Kim, Yang, Ethel, Wong, Kamehame, Agbandje-McKenna, Mavis, Chatterjee, Saswati
    Mol Ther, 2014;22(9):1625-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP).
    Authors: Rosen, David B, Leung, Ling Y, Louie, Brent, Cordeiro, James A, Conroy, Andrew, Shapira, Iuliana, Fields, Scott Z, Cesano, Alessand, Hawtin, Rachael
    J Transl Med, 2014;12(0):184.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Evaluation of engraftment and immunological tolerance after reduced intensity conditioning in a rhesus hematopoietic stem cell gene therapy model.
    Authors: Uchida N, Weitzel R, Evans M, Green R, Bonifacino A, Krouse A, Metzger M, Hsieh M, Donahue R, Tisdale J
    Gene Ther, 2014;21(2):148-57.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  88. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity.
    Authors: Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Wang, Xiaoming, Goard, Carolyn, Jhas, Bozhena, Schimmer, Aaron D
    PLoS ONE, 2014;9(5):e95281.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. BCR-ABL-induced deregulation of the IL-33/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients.
    Authors: Levescot A, Flamant S, Basbous S, Jacomet F, Feraud O, Anne Bourgeois E, Bonnet M, Giraud C, Roy L, Barra A, Chomel J, Turhan A, Guilhot F, Girard J, Gombert J, Herbelin A
    Cancer Res, 2014;74(10):2669-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment.
    Authors: Horwitz, Mitchell, Chao, Nelson J, Rizzieri, David A, Long, Gwynn D, Sullivan, Keith M, Gasparetto, Cristina, Chute, John P, Morris, Ashley, McDonald, Carolyn, Waters-Pick, Barbara, Stiff, Patrick, Wease, Steven, Peled, Amnon, Snyder, David, Cohen, Einat Ga, Shoham, Hadas, Landau, Efrat, Friend, Etty, Peleg, Iddo, Aschengrau, Dorit, Yackoubov, Dima, Kurtzberg, Joanne, Peled, Tony
    J Clin Invest, 2014;124(7):3121-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value.
    Authors: Vannucchi, A M, Rotunno, G, Bartalucci, N, Raugei, G, Carrai, V, Balliu, M, Mannarelli, C, Pacilli, A, Calabresi, L, Fjerza, R, Pieri, L, Bosi, A, Manfredini, R, Guglielmelli, P
    Leukemia, 2014;28(9):1811-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector.
    Authors: Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou M, Chan J
    PLoS ONE, 2014;9(8):e104805.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma.
    Authors: Todd J, Scurr L, Becker T, Kefford R, Rizos H
    Oncogene, 2014;33(2):236-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.
    Authors: Kazuki, Yasuhiro, Yakura, Yuwna, Abe, Satoshi, Osaki, Mitsuhik, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Honma, Kazuhisa, Suemori, Hirofumi, Yamazaki, Satoshi, Sakuma, Tetsushi, Toki, Tsutomu, Shimizu, Ritsuko, Nakauchi, Hiromits, Yamamoto, Takashi, Oshimura, Mitsuo
    Sci Rep, 2014;4(0):6136.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.
    Authors: Morishima, Tatsuya, Watanabe, Ken-ichi, Niwa, Akira, Hirai, Hideyo, Saida, Satoshi, Tanaka, Takayuki, Kato, Itaru, Umeda, Katsutsu, Hiramatsu, Hidefumi, Saito, Megumu K, Matsubara, Kousaku, Adachi, Souichi, Kobayashi, Masao, Nakahata, Tatsutos, Heike, Toshio
    Haematologica, 2014;99(1):19-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells.
    Authors: Khoo M, Carlin S, Lutherborrow M, Jayaswal V, Ma D, Moore J
    Aging Cell, 2014;13(4):744-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells.
    Authors: Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L
    J Leukoc Biol, 2014;95(6):893-901.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
    Authors: Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J
    Blood, 2014;123(8):1239-49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.
    Authors: Wu C, Li B, Lu R, Koelle S, Yang Y, Jares A, Krouse A, Metzger M, Liang F, Lore K, Wu C, Donahue R, Chen I, Weissman I, Dunbar C
    Cell Stem Cell, 2014;14(4):486-99.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  100. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells.
    Authors: Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S
    Stem Cells, 2014;32(5):1337-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.
    Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
    J Invest Dermatol, 2014;134(5):1246-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
    Authors: Yu, Jianhua, Peng, Yong, Wu, Lai-Chu, Xie, Zhiliang, Deng, Youcai, Hughes, Tiffany, He, Shun, Mo, XiaoKui, Chiu, Ming, Wang, Qi-En, He, Xiaoming, Liu, Shujun, Grever, Michael, Chan, Kenneth, Liu, Zhongfa
    PLoS ONE, 2013;8(2):e55934.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells.
    Authors: Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D
    Mol Ther, 2013;21(5):1044-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
    Authors: Smith A, Bowers S, Stratman A, Davis G
    PLoS ONE, 2013;8(12):e85147.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
    Authors: Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G
    Cell Stem Cell, 2013;13(4):459-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming.
    Authors: Lee M, Prasain N, Chae H, Kim Y, Mantel C, Yoder M, Broxmeyer H
    Stem Cells, 2013;31(4):666-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14.
    Authors: Farrer R, Farrer J, DeVries G
    J Biol Chem, 2013;288(16):11066-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples.
    Authors: Bachet J, Tabone-Eglinger S, Dessaux S, Besse A, Brahimi-Adouane S, Emile J, Blay J, Alberti L
    PLoS ONE, 2013;8(4):e61103.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. beta-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model.
    Authors: Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C
    PLoS ONE, 2013;8(11):e80403.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells.
    Authors: Ichii, Michiko, Frank, Mark Bar, Iozzo, Renato V, Kincade, Paul W
    Blood, 2012;119(7):1683-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene.
    Authors: Li Q, Ramirez-Bergeron D, Dunwoodie S, Yang Y
    J Biol Chem, 2012;287(34):29088-100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms.
    Blood Cancer J, 2012;2(0):e87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
    BMC Cancer, 2012;12(0):431.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
    Gene Ther, 2012;19(10):1035-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.
    Authors: Niwa A, Heike T, Umeda K
    PLoS ONE, 2011;6(7):e22261.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
    Authors: Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B
    Blood, 2011;117(3):839-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor.
    Authors: Torrano V, Procter J, Cardus P
    Blood, 2011;118(18):4910-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Optimal conditions for lentiviral transduction of engrafting human CD34+ cells.
    Authors: Uchida N, Hsieh MM, Hayakawa J, Madison C, Washington KN, Tisdale JF
    Gene Ther., 2011;18(11):1078-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Dynamic interaction networks in a hierarchically organized tissue.
    Authors: Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW
    Mol. Syst. Biol., 2010;6(0):417.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses.
    Authors: Duraisingham SS, Hornig J, Gotch F, Patterson S
    J. Immunol., 2009;183(4):2242-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.
    Authors: Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT
    J. Immunol., 2009;183(3):1739-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
    Authors: Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(24):9826-30.
  123. MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice.
    Authors: Margulis A, Nocka KH, Wood NL, Wolf SF, Goldman SJ, Kasaian MT
    Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(2):L236-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.
    Authors: Aerbajinai W, Zhu J, Kumkhaek C, Chin K, Rodgers GP
    Blood, 2009;114(1):187-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
    Authors: Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE
    Blood, 2009;114(24):5091-101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15.
    Authors: McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS
    Exp. Hematol., 2008;36(5):598-608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells.
    Authors: Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J
    Exp. Hematol., 2008;36(9):1121-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
    Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
    Exp. Hematol., 2008;36(8):1035-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.
    Authors: Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P
    J. Immunol., 2008;181(4):2772-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions.
    Authors: Gunetti M, Ferrero I, Rustichelli D, Berger M, Gammaitoni L, Timeus F, Piacibello W, Aglietta M, Fagioli F
    Exp. Hematol., 2008;36(2):235-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium.
    Authors: Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, Camussi G, Pegoraro L, Brizzi MF
    Blood, 2007;109(10):4264-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells.
    Authors: Srivastava AS, Nedelcu E, Esmaeli-Azad B, Mishra R, Carrier E
    Stem Cells, 2007;25(6):1456-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis.
    Authors: Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, Feghali-Bostwick CA, Silver RM
    Arthritis Rheum., 2007;56(7):2432-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts.
    Authors: Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U
    Stem Cells, 2007;25(8):1862-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells.
    Authors: Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y
    Exp. Hematol., 2006;34(6):760-9.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Isolation of a novel population of multipotent adult stem cells from human hair follicles.
    Authors: Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X
    Am. J. Pathol., 2006;168(6):1879-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells.
    Authors: Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, Zini R, Salati S, Tagliafico E, Manfredini R, Grande A, Ferrari S
    Cell Death Differ., 2006;13(10):1686-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector.
    Authors: Kahl CA, Tarantal AF, Lee CI, Jimenez DF, Choi C, Pepper K, Petersen D, Fletcher MD, Leapley AC, Fisher J, Burns TS, Ultsch MN, Dorey FJ, Kohn DB
    Exp. Hematol., 2006;34(3):369-81.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  139. Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells.
    Authors: Hsieh FH, Sharma P, Gibbons A, Goggans T, Erzurum SC, Haque SJ
    Proc. Natl. Acad. Sci. U.S.A., 2005;102(40):14380-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Establishment and characterization of continuous hematopoietic progenitors-derived pig normal mast cell lines.
    Authors: Femenia F, Arock M, Leriche L, Delouis C, Millet G, Ben Hamouda N, Cote M, Alliot A, Lilin T, Pinton A, Iannucceli N, Parodi AL, Boireau P
    Life Sci., 2005;77(7):808-23.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Growth hormone-induced stimulation of multilineage human hematopoiesis.
    Authors: Hanley MB, Napolitano LA, McCune JM
    Stem Cells, 2005;23(8):1170-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Growth differentiation factor-9 and stem cell factor promote primordial follicle formation in the hamster: modulation by follicle-stimulating hormone.
    Authors: Wang J, Roy SK
    Biol. Reprod., 2004;70(3):577-85.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Prospective isolation of human clonogenic common myeloid progenitors.
    Authors: Manz MG, Miyamoto T, Akashi K, Weissman IL
    Proc. Natl. Acad. Sci. U.S.A., 2002;99(18):11872-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCF.
    Authors: Da Silva CA, 2019, Kassel O, Mathieu E, Massard G, Gasser B, Frossard N
    , 2002;135(7):1634-40.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  145. A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
    Authors: Shih CC, Hu MC, Hu J
    Blood, 2000;95(6):1957-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model.
    Authors: Gomez-Navarro J, Contreras JL, Arafat W, Jiang XL, Krisky D, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM
    Gene Ther., 2000;7(1):43-52.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  147. The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation.
    Authors: Drouet M, 49153, Mathieu J, Grenier N, Multon E, Sotto JJ, Herodin F
    Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance, 1999;17(5):273-85.
    Species: Primate - Papio anubis (Olive Baboon)
    Sample Types: Whole Cells
    Applications: Bioassay
  148. Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.
    Authors: Barcena A, Park SW, Banapour B, Muench MO, Mechetner E
    Blood, 1996;88(6):2013-25.
    Species: Human
    Sample Types:
    Applications: Bioassay
  149. Defining human dendritic cell progenitors by multiparametric flow cytometry.
    Authors: Breton G, Lee J, Liu K, Nussenzweig M
    Nat Protoc, 0;10(9):1407-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Average Rating: 4.6 (Based on 5 Reviews)

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Recombinant Human SCF Protein
By Anonymous on 11/20/2020
Application: Stem/Immune cell maintenance or differentiation

Recombinant Human SCF Protein
By Anonymous on 10/16/2020
Application: CellProlif
Reason for Rating: This product is perfect for proliferation of human megakaryocyte progenitor cells.

Recombinant Human SCF Protein
By Anonymous on 10/13/2020
Application: Stem/Immune cell maintenance or differentiation

The result of stem differentiation is good.


Recombinant Human SCF Protein
By Anonymous on 03/28/2018
Application: Binding assay/Protein-protein interaction

Recombinant Human SCF Protein
By Anonymous on 12/15/2016
Application: Stem/Immune cell maintenance or differentiation

I used iPSCs to produce red blood cell using SCF for differentiation.