Recombinant Mouse CD79A Protein, CF
Recombinant Mouse CD79A Protein, CF Summary
Leu29-Arg137, with a C-terminal 6-His tag
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS and DTT.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
CD79A (also known as Mb-1, Ig alpha and B cell antigen receptor complex-associated protein alpha -chain) is a 30-40 kDa member of the Ig-Superfamily. It is expressed on B cells, and forms a covalent heterodimer with CD79B. Heterodimers of CD79A and CD79B interacts non-covalently with membrane Ig, forming the B cell antigen receptor (BCR) (1). Within this complex, membrane Ig detects antigen while CD79AB initiates signaling (1). CD79A is essential for the differentiation of pre-B cells, and the pre-BCR regulates the surface expression of IL-7R (2). Mature mouse CD79A is a type I transmembrane glycoprotein. It contains an extracellular region (aa 29-137) with one C2-type Ig-like domain (aa 29-117), and an ITAM-containing cytoplasmic domain (aa 171-199) (3). Mouse CD79A and CD79B share only 22% amino acid (aa) identity. Over aa 29-137, mouse CD79A shares 57% and 80% amino acid identity with human and rat CD79A, respectively.
- Tseng, J. et al. (1997) Blood, 89:1513.
- Kurosaki, T. (2000) Current opinion in immunology, 12:276.
- Radaev, Sergei, et al. (2010) Structure 18:934.
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