Recombinant Mouse SCF Protein, CF

(90 citations)   
  • Purity
    >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 2.5-10 ng/mL.
  • Source
    E. coli-derived Lys26-Ala189, with an N-terminal Met
  • Accession #
  • N-terminal Sequence
    Analysis
    Met
  • Predicted Molecular Mass
    18.6 kDa
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
455-MC/CF
 
455-MC
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Mouse SCF/c-kit Ligand (Catalog # 455-MC/CF) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 2.5-10 ng/mL.
1 μg/lane of Recombinant Mouse SCF/c-kit was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.
Background: SCF/c-kit Ligand

Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein (1). It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1 - 7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). Mature mouse SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail (9). The ECD shows both N-linked and O-linked glycosylation (10). Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice (11, 12). An alternately spliced isoform of mouse SCF lacks 28 aa that encompasses the primary proteolytic recognition site (13). Within the ECD of the short isoform (corresponding to this recombinant protein), mouse SCF shares 93% aa sequence identity with rat SCF and 72% - 75% with canine, feline, and human SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (14). Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c-kit to trigger receptor dimerization and signaling (15). SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (16).

  • References:
    1. Ashman, L.K. (1999) Int. J. Biochem. Cell Biol. 31:1037.
    2. Sette, C. et al. (2000) Int. J. Dev. Biol. 44:599.
    3. Yoshida, H. et al. (2001) J. Invest. Dermatol. Symp. Proc. 6:1.
    4. Erlandsson, A. et al. (2004) Exp. Cell Res. 301:201.
    5. Kapur, R. et al. (2002) Blood 100:1287.
    6. Wang, C.-H. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:540.
    7. Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039.
    8. Reber, L. et al. (2006) Eur. J. Pharmacol. 533:327.
    9. Huang, E. et al. (1990) Cell 63:225.
    10. Arakawa, T. et al. (1991) J. Biol. Chem. 266:18942.
    11. Majumdar, M.K. et al. (1994) J. Biol. Chem. 269:1237.
    12. Brannan, C.I. et al. (1991) Proc. Natl. Acad. Sci. 88:4671.
    13. Flanagan, J.G. et al. (1991) Cell 64:1025.
    14. Martin, F.H. et al., 1990, Cell 63:203.
    15. Lemmon, M.A. et al. (1997) J. Biol. Chem. 272:6311.
    16. Kanellakis, P. et al. (2006) Cardiovasc. Res. 70:117.
  • Long Name:
    Stem Cell Factor
  • Entrez Gene IDs:
    4254 (Human); 17311 (Mouse); 60427 (Rat); 403507 (Canine); 493937 (Feline)
  • Alternate Names:
    c-kit Ligand; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; KIT ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SLF; steel factor
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

90 Citations: Showing 1 - 10
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Sample Type
  1. Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin
    Authors: NJ Huang, N Pishesha, J Mukherjee, S Zhang, R Deshycka, V Sudaryo, M Dong, CB Shoemaker, HF Lodish
    Nat Commun, 2017;8(1):423.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1
    Authors: S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra
    Nat. Methods, 2017;14(5):531-538.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1)
    Authors: KZ Oben, BW Gachuki, SS Alhakeem, MK McKenna, Y Liang, DK St Clair, VM Rangnekar, S Bondada
    PLoS ONE, 2017;12(1):e0169767.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. Mesenchymal Cell Reprogramming in Experimental MPLW515L Mouse Model of Myelofibrosis
    Authors: Y Han, L Yue, M Wei, X Ren, Z Shao, L Zhang, RL Levine, PK Epling-Bur
    PLoS ONE, 2017;12(1):e0166014.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  5. Anti-KIT Monoclonal Antibody Treatment Enhances the Anti-Tumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression
    Authors: AJ Garton, S Seibel, L Lopresti-M, L Crew, N Janson, S Mandiyan, ES Trombetta, S Pankratz, TM LaVallee, R Gedrich
    Mol. Cancer Ther, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  6. Hematopoietic pannexin 1 function is critical for neuropathic pain
    Authors: JL Weaver, S Arandjelov, G Brown, S K Mendu, M S Schappe, MW Buckley, YH Chiu, S Shu, JK Kim, J Chung, J Krupa, V Jevtovic-T, BN Desai, KS Ravichandr, DA Bayliss
    Sci Rep, 2017;7(0):42550.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment
    Authors: B Guo, X Huang, S Cooper, HE Broxmeyer
    Nat. Med, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors
    Authors: A Itoh-Nakad, M Matsumoto, H Kato, J Sasaki, Y Uehara, Y Sato, R Ebina-Shib, M Morooka, R Funayama, K Nakayama, K Ochiai, A Muto, K Igarashi
    Cell Rep, 2017;18(10):2401-2414.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation
    Authors: Y Zhao, K Wu, C Nguyen, G Smbatyan, E Melendez, Y Higuchi, Y Chen, M Kahn
    PLoS ONE, 2017;12(5):e0177245.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  10. Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease
    Authors: J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin
    Mol Ther Methods Clin Dev, 2017;5(0):241-258.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. Lentiviral Fluorescent Genetic Barcoding for Multiplex Fate Tracking of Leukemic Cells
    Authors: T Maetzig, J Ruschmann, L Sanchez Mi, CK Lai, N von Krosig, RK Humphries
    Mol Ther Methods Clin Dev, 2017;6(0):54-65.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. Interaction of primary mast cells with Borrelia burgdorferi (sensu stricto): role in transmission and dissemination in C57BL/6 mice
    Authors: Q Bernard, Z Wang, A Di Nardo, N Boulanger
    Parasit Vectors, 2017;10(1):313.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency
    Authors: D Sainz de l, A Moratilla, V Aparicio, C Lorca, Y Alcaina, D Martín, MP De Miguel
    Oxid Med Cell Longev, 2017;2017(0):4745252.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis
    PLoS ONE, 2016;11(5):e0154630.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the in Vivo Regeneration of the Hematopoietic Stem Cell Pool
    Authors: Franziska Ruf
    Stem Cells, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency
    Stem Cell Reports, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. Reprogramming M�ller glia via in vivo cell fusion regenerates murine photoreceptors
    J Clin Invest, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells
    Authors: L Dimitrov, D Pedersen, KH Ching, H Yi, EJ Collarini, S Izquierdo, MC van de Lav, PA Leighton
    PLoS ONE, 2016;11(4):e0154303.
    Species: Chicken
    Sample Type: Whole Cells
    Application: Bioassay
  19. Generation of chickens expressing Cre recombinase
    Authors: PA Leighton, D Pedersen, K Ching, EJ Collarini, S Izquierdo, R Jacob, MC van de Lav
    Transgenic Res, 2016;0(0):.
    Species: Chicken
    Sample Type: Whole Cells
    Application: Bioassay
  20. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
    Nat. Med, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  21. Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2
    Cancer Discov, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  22. The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis
    Cell Death Dis, 2016;7(11):e2479.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  23. Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis
    Oncogene, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  24. Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
    Nat Commun, 2016;7(0):13396.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  25. Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
    Nat. Med., 2016;22(6):672-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. In�Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells
    Cell Rep, 2016;17(10):2789-2804.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. Systemic Ablation of MMP9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL-6 Expression in the Bone Marrow
    Mol Cancer Res, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  28. miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
    Authors: X Jiang, C Hu, S Arnovitz, J Bugno, M Yu, Z Zuo, P Chen, H Huang, B Ulrich, S Gurbuxani, H Weng, J Strong, Y Wang, Y Li, J Salat, S Li, AG Elkahloun, Y Yang, MB Neilly, RA Larson, MM Le Beau, T Herold, SK Bohlander, PP Liu, J Zhang, Z Li, C He, J Jin, Hon
    Nat Commun, 2016;7(0):11452.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  29. Arid3b Is Critical for B Lymphocyte Development
    PLoS ONE, 2016;11(8):e0161468.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  30. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.
    Authors: Kim P, Nakano H, Das P, Chen M, Rowe R, Chou S, Ross S, Sakamoto K, Zon L, Schlaeger T, Orkin S, Nakano A, Daley G
    J Exp Med, 2015;212(5):633-48.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  31. CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor.
    Authors: Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, Akashi K
    Stem Cells, 2015;33(3):976-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy.
    Authors: Schumacher A, Denecke B, Braunschweig T, Stahlschmidt J, Ziegler S, Brandenburg L, Stope M, Martincuks A, Vogt M, Gortz D, Camporeale A, Poli V, Muller-Newen G, Brummendorf T, Ziegler P
    J Hematol Oncol, 2015;8(0):64.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  33. Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.
    Authors: Goldenson B, Kirsammer G, Stankiewicz M, Wen Q, Crispino J
    Blood, 2015;125(13):2141-50.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  34. Targeted 25-hydroxyvitamin D3 1alpha-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice.
    Authors: Li B, Baylink D, Walter M, Lau K, Meng X, Wang J, Cherkas A, Tang X, Qin X
    Mol Ther, 2015;23(2):339-51.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  35. Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.
    Authors: Bender M, Giannini S, Grozovsky R, Jonsson T, Christensen H, Pluthero F, Ko A, Mullally A, Kahr W, Hoffmeister K, Falet H
    Blood, 2015;125(6):1014-24.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain.
    Authors: Suzuki, Norio, Mukai, Harumi Y, Yamamoto, Masayuki
    PLoS ONE, 2015;10(3):e0119442.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  37. Grb10 is involved in BCR-ABL-positive leukemia in mice.
    Authors: Illert, A L, Albers, C, Kreutmair, S, Leischner, H, Peschel, C, Miething, C, Duyster, J
    Leukemia, 2015;29(4):858-68.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  38. Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes.
    Authors: Huan J, Hornick N, Goloviznina N, Kamimae-Lanning A, David L, Wilmarth P, Mori T, Chevillet J, Narla A, Roberts C, Loriaux M, Chang B, Kurre P
    Leukemia, 2015;29(12):2285-95.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  39. Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1.
    Authors: Fukuda, S, Hoggatt, J, Singh, P, Abe, M, Speth, J M, Hu, P, Conway, E M, Nucifora, G, Yamaguchi, S, Pelus, L M
    Leukemia, 2015;29(2):433-40.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  40. FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
    Authors: Begonja A, Pluthero F, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo R, Nakamura F, Lehman W, Plomann M, Hoffmeister K, Kahr W, Hartwig J, Falet H
    Blood, 2015;126(1):80-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  41. Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.
    Authors: Liu D, Suchard S, Nadler S, Ford M
    PLoS ONE, 2015;10(6):e0130490.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  42. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.
    Authors: Bando J, Liang H, Locksley R
    Nat Immunol, 2015;16(2):153-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  43. HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.
    Authors: Wang H, Bei L, Shah C, Hu L, Eklund E
    J Immunol, 2015;194(11):5375-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  44. CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice.
    Authors: Gonzalez Roldan N, Orinska Z, Ewers H, Bulfone-Paus S
    Eur J Immunol, 2015;46(2):432-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy.
    Authors: Wang L, Rao T, Rowe R, Nguyen P, Sullivan J, Pearson D, Doulatov S, Wu L, Lindsley R, Zhu H, DeAngelo D, Daley G, Wagers A
    Leukemia, 2015;29(6):1320-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  46. In Vitro Spermatogenesis in Explanted Adult Mouse Testis Tissues.
    Authors: Sato T, Katagiri K, Kojima K, Komeya M, Yao M, Ogawa T
    PLoS ONE, 2015;10(6):e0130171.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  47. Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice.
    Authors: von Wnuck Lipinski K, Sattler K, Peters S, Weske S, Keul P, Klump H, Heusch G, Gothert J, Levkau B
    J Immunol, 2015;196(4):1655-65.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
    Authors: Roderick, Justine, Tesell, Jessica, Shultz, Leonard, Brehm, Michael, Greiner, Dale L, Harris, Marian H, Silverman, Lewis B, Sallan, Stephen, Gutierrez, Alejandr, Look, A Thomas, Qi, Jun, Bradner, James E, Kelliher, Michelle
    Blood, 2014;123(7):1040-50.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  49. TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.
    Authors: Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer M, Zhang H, Hogquist K, Evavold B, Vignali D
    J Immunol, 2014;193(2):571-9.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  50. Critical role for NAD glycohydrolase in regulation of erythropoiesis by hematopoietic stem cells through control of intracellular NAD content.
    Authors: Nam T, Park K, Shawl A, Kim B, Han M, Kim Y, Moss J, Kim U
    J Biol Chem, 2014;289(23):16362-73.
    Species: Rabbit
    Sample Type: Whole Cells
    Application: Bioassay
  51. BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells.
    Authors: Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L
    Exp Cell Res, 2014;320(1):54-61.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  52. Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke.
    Authors: North, Matthew, Shuga, Joe, Fromowitz, Michele, Loguinov, Alexandr, Shannon, Kevin, Zhang, Luoping, Smith, Martyn T, Vulpe, Chris D
    BMC Cancer, 2014;14(0):6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  53. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.
    Authors: Zimdahl, Bryan, Ito, Takahiro, Blevins, Allen, Bajaj, Jeevisha, Konuma, Takaaki, Weeks, Joi, Koechlein, Claire S, Kwon, Hyog You, Arami, Omead, Rizzieri, David, Broome, H Elizab, Chuah, Charles, Oehler, Vivian G, Sasik, Roman, Hardiman, Gary, Reya, Tannisht
    Nat Genet, 2014;46(3):245-52.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  54. Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells.
    Authors: Luyten A, Zang C, Liu X, Shivdasani R
    Genes Dev, 2014;28(16):1827-39.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  55. Computational promoter modeling identifies the modes of transcriptional regulation in hematopoietic stem cells.
    Authors: Park S, Umemoto T, Saito-Adachi M, Shiratsuchi Y, Yamato M, Nakai K
    PLoS ONE, 2014;9(4):e93853.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  56. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.
    Authors: Patnode M, Bando J, Krummel M, Locksley R, Rosen S
    J Exp Med, 2014;211(7):1281-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  57. Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion.
    Authors: Chung, Jie-Yu, Figgett, William, Fairfax, Kirsten, Bernard, Claude, Chan, James, Toh, Ban-Hock, Mackay, Fabienne, Alderuccio, Frank
    J Immunol, 2014;192(6):2593-601.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  58. Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.
    Authors: Zhang H, Nieves J, Fraser S, Isern J, Douvaras P, Papatsenko D, D'Souza S, Lemischka I, Dyer M, Baron M
    Stem Cells, 2014;32(1):191-203.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  59. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
    Authors: Nagareddy P, Kraakman M, Masters S, Stirzaker R, Gorman D, Grant R, Dragoljevic D, Hong E, Abdel-Latif A, Smyth S, Choi S, Korner J, Bornfeldt K, Fisher E, Dixit V, Tall A, Goldberg I, Murphy A
    Cell Metab, 2014;19(5):821-35.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  60. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.
    Authors: Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata K, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T
    Blood, 2014;123(25):3932-42.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  61. Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.
    Authors: Wallington-Beddoe C, Powell J, Tong D, Pitson S, Bradstock K, Bendall L
    Cancer Res, 2014;74(10):2803-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  62. Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism.
    Authors: Reber L, Daubeuf F, Pejler G, Abrink M, Frossard N
    J Immunol, 2014;192(4):1847-54.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  63. Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 xi chain on T cells, abrogating alloreactive T cells.
    Authors: Kim E, Miyake B, Aggarwal M, Voetlause R, Griffith M, Zavazava N
    Immunology, 2014;142(3):421-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  64. Establishment of a mast cell line, NCL-2, without Kit mutation, derived from NC mouse bone marrow.
    Authors: Hiragun T, Yanase Y, Okabe T, Hiragun M, Kawai M, Hide M
    FEBS Open Bio, 2014;4(0):342-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  65. Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.
    Authors: Krutikov K, Zheng Y, Chesney A, Huang X, Vaags A, Evdokimova V, Hough M, Chen E
    PLoS ONE, 2014;9(2):e89649.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  66. The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.
    Authors: Liu X, Yuan H, Peres L, Chen S, Chen Z, de The H, Zhou J, Zhu J
    PLoS ONE, 2014;9(8):e104906.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  67. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.
    Authors: Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M
    Blood, 2014;124(9):1393-403.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  68. Induction of a hemogenic program in mouse fibroblasts.
    Authors: Pereira C, Chang B, Qiu J, Niu X, Papatsenko D, Hendry C, Clark N, Nomura-Kitabayashi A, Kovacic J, Ma'ayan A, Schaniel C, Lemischka I, Moore K
    Cell Stem Cell, 2013;13(2):205-18.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  69. Identification of transcription factors for lineage-specific ESC differentiation.
    Authors: Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M
    Stem Cell Reports, 2013;1(6):545-59.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  70. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.
    Authors: Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S
    Eur J Immunol, 2013;43(4):979-88.
  71. The critical role of mast cell-derived hypoxia-inducible factor-1alpha in human and mice melanoma growth.
    Authors: Jeong H, Oh H, Nam S, Han N, Kim Y, Kim J, Lee S, Kim M, Moon P, Kim H, Oh H
    Int J Cancer, 2013;132(11):2492-501.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  72. Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
    Authors: Cook BD, Liu S, Evans T
    Blood, 2011;117(24):6489-97.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  73. Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.
    Authors: Kinzfogl J, Hangoc G, Broxmeyer HE
    Blood, 2011;118(3):565-75.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  74. A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst.
    Authors: Artus J, Panthier JJ, Hadjantonakis AK
    Development, 2010;137(20):3361-72.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  75. An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells.
    Authors: Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T
    J. Immunol., 2009;183(2):925-36.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  76. Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling.
    Authors: Dolgachev VA, Ullenbruch MR, Lukacs NW, Phan SH
    Am. J. Pathol., 2009;174(2):390-400.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  77. Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells.
    Authors: Huynh H, Iizuka S, Kaba M, Kirak O, Zheng J, Lodish HF, Zhang CC
    Stem Cells, 2008;26(6):1628-35.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  78. Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.
    Authors: Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Mullner EW
    Blood, 2008;112(9):3878-88.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  79. The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice.
    Authors: Zhang P, Nelson S, Bagby GJ, Siggins R, Shellito JE, Welsh DA
    Stem Cells, 2008;26(7):1778-86.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  80. Commonly dysregulated genes in murine APL cells.
    Authors: Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ
    Blood, 2007;109(3):961-70.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  81. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
    Authors: Rajesh&lt;/LastName&gt;&lt;ForeNam D&lt;/Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF
    Stem Cells, 2007;25(2):490-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  82. IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis.
    Authors: Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K
    J. Immunol., 2007;179(10):7128-36.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  83. Nociceptive tuning by stem cell factor/c-Kit signaling.
    Authors: Milenkovic N, Frahm C, Gassmann M, Griffel C, Erdmann B, Birchmeier C, Lewin GR, Garratt AN
    Neuron, 2007;56(5):893-906.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  84. Cytokine-containing gelfoam implants at a postsurgical tumor excision site to stimulate local immune reactivity.
    Authors: Young MR
    Int. J. Cancer, 2006;119(1):133-8.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  85. c-kit delineates a distinct domain of progenitors in the developing kidney.
    Authors: Schmidt-Ott KM, Chen X, Paragas N, Levinson RS, Mendelsohn CL, Barasch J
    Dev. Biol., 2006;299(1):238-49.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  86. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
    Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
    Blood, 2006;108(6):2041-4.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  87. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity.
    Authors: Yilmaz OH, Kiel MJ, Morrison SJ
    Blood, 2005;107(3):924-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  88. Immortalization of mouse germ line stem cells.
    Authors: Hofmann MC, Braydich-Stolle L, Dettin L, Johnson E, Dym M
    Stem Cells, 2005;23(2):200-10.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  89. The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
    Authors: Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
    Arch. Dermatol. Res., 2001;293(10):508-14.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  90. Stem cell factor improves the repopulating ability of primitive hematopoietic stem cells after sublethal irradiation (and, to a lesser extent) after bone marrow transplantation in mice.
    Authors: Gardner RV, 48657, Oliver P, Astle CM
    Involvement of ?-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum, 1998;16(2):112-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
Expand to show all 90 Citations
Animal-Free Recombinant Proteins
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Recombinant Mouse SCF, Animal-Free Protein

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