(RS)-MCPG disodium salt
Chemical Name: (RS)-α-Methyl-4-carboxyphenylglycine disodium salt
Biological Activity(RS)-MCPG disodium salt is a sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist.
S-enantiomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Phenylglycine derivatives as metabotropic glutamate receptor antagonists.
Collingridge and Watkins
Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1.
Joly et al.
Competitive antagonist at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG).
Eaton et al.
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(RS)-MCPG disodium salt was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG disodium salt works as expected; the effects and time interval for response development are same with those of (RS)-MCPG, but the salt is much easier soluble.