(RS)-MCPG disodium salt

Catalog # Availability Size / Price Qty
3696/10
3696/50
(RS)-MCPG disodium salt | Group I mGluR Antagonists
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Description: Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)

Chemical Name: (RS)-α-Methyl-4-carboxyphenylglycine disodium salt

Purity: ≥99%

Product Details
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Reviews (1)

Biological Activity

(RS)-MCPG disodium salt is a sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer also available.

Technical Data

M.Wt:
253.16
Formula:
C10H9NNa2O4
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Phenylglycine derivatives as metabotropic glutamate receptor antagonists.
    Collingridge and Watkins
    TiPS, 1994;15:333
  2. Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1.
    Joly et al.
    J.Neurosci., 1995;15:3970
  3. Competitive antagonist at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG).
    Eaton et al.
    Eur.J.Pharmacol.Mol.Pharmacol.Sect., 1993;244:195

Product Datasheets

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Suppression of mGluR action triggered by glutamate application
By Sergiy Sylantyev on 10/15/2020
Application: Species: Human

(RS)-MCPG disodium salt was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG disodium salt works as expected; the effects and time interval for response development are same with those of (RS)-MCPG, but the salt is much easier soluble.

Reference

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