Catalog Number: 3657
Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Biological Activity
Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation.
    Raven et al.
    J.Biol.Chem., 2008;283:3097
  2. The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53.
    Baltiz et al.
    J.Biol.Chem., 2007;282:31675
  3. eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
    Costa-Mattioli et al.
    Cell, 2007;129:195

The citations listed below are publications that use Tocris products. Selected citations for Sal 003 include:

1 Citations: Showing 1 - 1

  1. Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice.
    Authors: Devi and Ohno
    PLoS One 2010;5:e12974

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