Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α
). Analog of salubrinal
(Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.
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PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation.
Raven et al.
The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53.
Baltiz et al.
eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
Costa-Mattioli et al.
The citations listed below are publications that use Tocris products. Selected citations for Sal 003 include:
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