Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Biological ActivityCell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation.
Raven et al.
The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53.
Baltiz et al.
eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
Costa-Mattioli et al.
Citations for Sal 003
The citations listed below are publications that use Tocris products. Selected citations for Sal 003 include:
2 Citations: Showing 1 - 2
GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
Cell Rep 2017;21(10):2895
Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice.
Authors: Devi and Ohno
PLoS One 2010;5:e12974
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Sal 003
There are currently no reviews for this product. Be the first to review Sal 003 and earn rewards!
Have you used Sal 003?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image