Sal 003

  ( 2 citations )    
Product Datasheet
Catalog Number:3657
Chemical Name:3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Product Details
Citations (2)
Reviews
Biological Activity
Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.
Technical Data
  • M.Wt:
    463.21
  • Formula:
    C18H15Cl4N3OS
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    1164470-53-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sal 003 include:

2 Citations: Showing 1 - 2
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  1. GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
    Authors: Krokowski
    Cell Rep  2017;21(10):2895
  2. Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice.
    Authors: Devi and Ohno
    PLoS One  2010;5:e12974

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