SAP102 Antibody

Name: SAP102 Antibody
Brand: Novus Biologicals
SKU: NB100-2063
Price: 389 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-2063

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

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Product Specifications

Immunogen

Synthetic peptide corresponding to residues G(83) P V P P K P V P G K N T P K L N G(100) of rat SAP102.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 12438413).

Localization

Synaptic membrane.

Specificity

SAP102

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SAP102 Antibody

Western Blot: SAP102 Antibody [NB100-2063]

Western Blot: SAP102 Antibody [NB100-2063] - Analysis of SAP102 on extract from COS cells transfected with rat SAP102.

Immunohistochemistry-Frozen: SAP102 Antibody [NB100-2063]

Immunohistochemistry-Frozen: SAP102 Antibody [NB100-2063] - Staining of Ammon's Horn and the dentate gyrus of the rat hippocampus.

Applications for SAP102 Antibody

Application

Recommended Usage

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

10 ug/ml

Western Blot

3 ug/ml

Application Notes

May be Useful in WB. WB: Detects an approx. 102 kDa protein representing SAP 102 in rat brain homogenate. IHC: Staining of SAP 102 in rat hippocampus yields a pattern consistent with post-synaptic localization.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SAP102

Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three ~90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

Alternate Names

discs, large homolog 3 (Drosophila), KIAA1232discs, large homolog 3 (neuroendocrine-dlg, Drosophila), MRX90MRX, NEDLGdisks large homolog 3, Neuroendocrine-DLG, SAP-102, SAP102NE-Dlg, Synapse-associated protein 102, XLMR

Entrez Gene IDs

1741 (Human); 53310 (Mouse); 58948 (Rat)

Gene Symbol

DLG3

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Product Specific Notices for SAP102 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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