SB 203580 hydrochloride

Catalog # Availability Size / Price Qty
SB 203580 hydrochloride | CAS No. 869185-85-3 | p38 Inhibitors
1 Image
Description: Selective inhibitor of p38 MAPK; water-soluble

Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride

Purity: ≥98%

Product Details
Citations (11)

Biological Activity

SB 203580 hydrochloride is a water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

Technical Data

Soluble to 25 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SB 203580 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 203580 hydrochloride include:

11 Citations: Showing 1 - 10

  1. Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
    Authors: Li Et al.
    Cell  2019;179:687
  2. Elevated sodium chloride drives type I IF. signaling in macrophages and increases antiviral resistance.
    Authors: Zhang Et al.
    J Biol Chem  2018;293:1030
  3. Establishment of mouse expanded potential stem cells.
    Authors: Yang Et al.
    Nature  2017;550:393
  4. Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1.
    Authors: Silpanisong Et al.
    Am J Physiol Cell Physiol  2017;313:C207
  5. Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
    Authors: Lukjanenko Et al.
    Nat Med  2016;22:897
  6. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated Ins secretion from human pancreatic islets.
    Authors: Edén Et al.
    Diabetologia  2015;58:2563
  7. Transient receptor potential vanilloid type 1 channel may modulate opioid reward.
    Authors: Nguyen Et al.
    Neuropsychopharmacology  2014;39:2414
  8. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol  2014;112:2388
  9. Inhibition of stathmin1 accelerates the metastatic process.
    Authors: Williams Et al.
    Cancer Res  2012;72:5407
  10. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction.
    Authors: Engel Et al.
    Proc Natl Acad Sci U S A  2006;103:15546


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SB 203580 hydrochloride

There are currently no reviews for this product. Be the first to review SB 203580 hydrochloride and earn rewards!

Have you used SB 203580 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.