SB 203580 hydrochloride

Catalog # Availability Size / Price Qty
1402/10
SB 203580 hydrochloride | CAS No. 869185-85-3 | p38 Inhibitors
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Description: Selective inhibitor of p38 MAPK; water-soluble

Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride

Purity: ≥98%

Product Details
Citations (11)
Reviews (4)

Biological Activity

SB 203580 hydrochloride is a water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

Technical Data

M.Wt:
413.89
Formula:
C21H16FN3OS.HCl
Solubility:
Soluble to 25 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
869185-85-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

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Citations for SB 203580 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 203580 hydrochloride include:

11 Citations: Showing 1 - 10

  1. Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
    Authors: Li Et al.
    Cell  2019;179:687
  2. Elevated sodium chloride drives type I IF. signaling in macrophages and increases antiviral resistance.
    Authors: Zhang Et al.
    J Biol Chem  2018;293:1030
  3. Establishment of mouse expanded potential stem cells.
    Authors: Yang Et al.
    Nature  2017;550:393
  4. Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1.
    Authors: Silpanisong Et al.
    Am J Physiol Cell Physiol  2017;313:C207
  5. Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
    Authors: Lukjanenko Et al.
    Nat Med  2016;22:897
  6. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated Ins secretion from human pancreatic islets.
    Authors: Edén Et al.
    Diabetologia  2015;58:2563
  7. Transient receptor potential vanilloid type 1 channel may modulate opioid reward.
    Authors: Nguyen Et al.
    Neuropsychopharmacology  2014;39:2414
  8. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol  2014;112:2388
  9. Inhibition of stathmin1 accelerates the metastatic process.
    Authors: Williams Et al.
    Cancer Res  2012;72:5407
  10. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction.
    Authors: Engel Et al.
    Proc Natl Acad Sci U S A  2006;103:15546

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Reviews for SB 203580 hydrochloride

Average Rating: 4.8 (Based on 4 Reviews)

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Generation of EPS-blastoids
By Anonymous on 02/27/2020
Application: Species: Mouse

10uM

PMID: 31626770

p38 MAPK pathway does not influence the LPA induced AMPK phosphorylation in microglia cells.
By lisha joshi on 06/18/2019
Application: Species: Mouse

We investigate the effect of LPA on microglia metabolic states. Trying to unravel possible pathways that maybe involved in this process, we used LPAR inhibitors and downstream inhibitors of MAPKs pathway. SB 203580 was used at a concentration of 10µM yet couldn't inhibit the expression of pAMPK. However the inhibitor was well tolerated by the cells.


SB 203580 ameliorates LPA-induced COX-2 expression
By Anonymous on 12/13/2018
Application: Species: Human

MG-63 cells were pre-incubated with 10 µM SB 203580 for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. SB 203580 inhibited COX-2 induction by LPA.


SB 203580 blunts 15d-PGJ2 induced pp38 expression
By Chintan Koyani on 10/13/2018
Application: Species: Mouse

HL-1 cells were incubated with p38 MAPK inhibitor (10 µM SB203580, 25 µMPD169316) or p42/44 MAPK kinase inhibitor (25 µM PD98059) for 30 min prior to 15dPGJ2 treatment (15 µM, 1 h). Immunoreactive bands for pp38 and pp42/44 MAPK expressions were followed by Western blot. SB203580 completely inhibited 15d-PGJ2 induced p38 phosphorylation (shown in Image).


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