Water-soluble salt of SB 203580
(Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50
values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β
2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β
. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies et al.
Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059.
Borsch-Haubold et al.
Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue.
Saklatvala et al.
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.
Cuenda et al.
FEBS Lett., 1995;364:229
The citations listed below are publications that use Tocris products. Selected citations for SB 203580 hydrochloride include:
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