Catalog Number: 1402
Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride
Biological Activity
Water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.
Technical Data
  • M.Wt:
    413.89
  • Formula:
    C21H16FN3OS.HCl
  • Solubility:
    Soluble to 25 mM in water with gentle warming
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    869185-85-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    Davies et al.
    Biochem.J., 2000;351:95
  2. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059.
    Borsch-Haubold et al.
    J.Biol.Chem., 1998;273:28766
  3. Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue.
    Saklatvala et al.
    J.Biol.Chem., 1996;271:6586
  4. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.
    Cuenda et al.
    FEBS Lett., 1995;364:229
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 203580 hydrochloride include:

6 Citations: Showing 1 - 6
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  1. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets.
    Authors: Edén Et al.
    Diabetologia 2015;58:2563
  2. Transient receptor potential vanilloid type 1 channel may modulate opioid reward.
    Authors: Nguyen Et al.
    Neuropsychopharmacology 2014;39:2414
  3. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol 2014;112:2388
  4. Inhibition of stathmin1 accelerates the metastatic process.
    Authors: Williams Et al.
    Cancer Res 2012;72:5407
  5. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction.
    Authors: Engel Et al.
    Proc Natl Acad Sci U S A 2006;103:15546
  6. Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro.
    Authors: Schlemper Et al.
    Br J Pharmacol 2005;145:740

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