SHFM3 Antibody

Name: SHFM3 Antibody
Brand: Novus Biologicals
SKU: NBP3-12201
Price: 439 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-12201

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Rat, Primate

Applications

Western Blot, ELISA, Immunoprecipitation, Dot Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

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Product Specifications

Immunogen

Synthetic peptide taken within amino acid region 240-290 on human FBX4 protein.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for SHFM3 Antibody

Western Blot: SHFM3 Antibody [NBP3-12201]

Western Blot: SHFM3 Antibody [NBP3-12201] - NBP3-12201 was diluted 1:500 in DiluObuffer. Apparent MW is 50 kDa. The higher MW 70 kDa was not labeled or expressed in these samples.

Applications for SHFM3 Antibody

Application

Recommended Usage

Dot Blot

1:4000

ELISA

1:4000

Immunoprecipitation

1:150

Western Blot

1:500

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.

Background: SHFM3

SHFM3 is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq]

Alternate Names

DAC, dactylin, F-box and WD repeat domain containing 4, F-box and WD-40 domain protein 4, F-box and WD-40 domain-containing protein 4, F-box/WD repeat protein 4, F-box/WD repeat-containing protein 4, Fbw4, FBW4split hand/foot malformation (ectrodactyly) type 3, FBWD4, SHFM3, SHSF3

Gene Symbol

FBXW4

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Product Documents for SHFM3 Antibody

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Certificate of Analysis

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Product Specific Notices for SHFM3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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