Simple Plex Control for Mouse CCL4/MIP-1 beta

Name: Simple Plex Control for Mouse CCL4/MIP-1 beta
Brand: R&D Systems
SKU: 896177
Price: 150 USD
Availability: InStock

R&D Systems | Catalog # 896177

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Citations

Product Documents

Control for use with Mouse CCL4/MIP-1 beta Simple Plex Cartridge Kit

Product Summary
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Mouse

Applications

Control, Simple Plex Automated Immunoassay

Product Summary for Simple Plex Control for Mouse CCL4/MIP-1 beta

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of mouse CCL4/MIP-1 beta concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

Formulation, Preparation, and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Background: CCL4/MIP-1 beta

CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.