Simple Plex Human IL-21 Cartridge New

Simple Plex Human IL-21 Cartridge Summary

*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.

Product Summary

Precision

Cell Culture Supernates, Serum, EDTA Plasma

Recovery

Linearity

Product Datasheets

Preparation and Storage

Background: IL-21

IL-21 (Interleukin-21) is member of the family of cytokines that utilize the common gamma chain as a receptor subunit. This subunit is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex of the common gamma chain and the IL-21-specific IL-21 R. IL-21 supports Tfh cell development, immunoglobulin affinity maturation, plasma cell differentiation, B cell memory responses, and the migration of dendritic cells to draining lymph nodes. It costimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. In addition, IL-21 suppresses cutaneous hypersensitivity reactions by limiting allergen-specific IgE production and mast cell degranulation.

Related Research Areas

• B Cell Markers
• Common gamma Chain Receptor Family
• Cytokines and Receptors in Tfh Cell Differentiation and Function
• Isolation, Culture, and Identification of Natural Killer Cells
• Multiple Sclerosis and Myelin Related Molecules
• Natural Killer T (NKT) Cells
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• Th17 Cells
• Th2 Cells
• Th22 Cells
• Th9 Cells