IL-21 Signaling Pathways

Click on the "Effects" button below to reveal the primary biological effects of IL-21 signaling in different immune cell types. Click on one of the other cytokines below for information on a different common cytokine receptor gamma-chain family member.

Common gamma chain
Common gamma chain
IL-21
IL-21
ProductsClose
ProductsClose
IL-21 R
IL-21 R
ProductsClose
ProductsClose
Jak1
Jak1
ProductsClose
ProductsClose
Jak3
Jak3
ProductsClose
ProductsClose
STAT1
STAT1
ProductsClose
ProductsClose
STAT3
STAT3
ProductsClose
STAT5
STAT5
STAT Dimer
STAT Dimer

IL-21 Receptor-Expressing Cells:
T cells, B cells, natural killer cells,
natural killer T cells, dendritic cells, lymphoid tissues

IL-21 Receptor-Expressing Cells:
T cells, B cells, natural killer cells,
natural killer T cells, dendritic cells, lymphoid tissues

PI 3-K
PI 3-K
ProductsClose
PDK-1
PDK-1
ProductsClose
Akt/PKB
Akt/PKB
p70 S6K
p70 S6K
ProductsClose
Bad
Bad
ProductsClose
GSK-3
GSK-3
Forkhead
Forkhead
ProductsClose
IRS
IRS
ProductsClose
ProductsClose
Shc
Shc
ProductsClose
ProductsClose
GRB2
GRB2
ProductsClose
ProductsClose
SOS
SOS
ProductsClose
ProductsClose
Ras
Ras
ProductsClose
Raf
Raf
MEK1/2
MEK1/2
ERK1/2
ERK1/2
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
PIP2
PIP2
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
ProductsClose
PIP3
PIP3
ProductsClose

Anti-Apoptotic

Anti-Apoptotic

Mitogenic

Mitogenic

Target Genes
Target Genes

Overview of IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types

Interleukin-21 (IL-21) is the most recently described cytokine belonging to the common cytokine receptor gamma-chain family. Like other common gamma chain family members, IL-21 is a four alpha-helix bundle type I cytokine. It signals through a receptor complex consisting of IL-21 R and common gamma-chain/IL-2 R gamma. IL-21 is produced primarily by CD4+ T cells and natural killer T (NKT) cells and has a broad range of effects on a number of different cell types. IL-21 signaling in CD4+ T cells is required for both Th17 differentiation and the generation of T follicular helper (Tfh) cells, which support B cell differentiation and antibody production in germinal centers. IL-21 also directly regulates B cell proliferation and apoptosis in a context-dependent manner and can promote immunoglobulin production and isotype class switching. In addition, IL-21 signaling enhances the cytotoxicity of CD8+ T cells, natural killer cells, and NKT cells.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.