SMAC/Diablo Antibody (RM271)

Name: SMAC/Diablo Antibody (RM271)
Brand: Novus Biologicals
SKU: NBP2-61586
Price: 439 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-61586

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM271 expressed in HEK293

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Product Specifications

Immunogen

A peptide corresponding to the C-terminus of Human SMAC/Diablo

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SMAC/Diablo Antibody (RM271)

Western Blot: SMAC/Diablo Antibody (RM271) [NBP2-61586]

Western Blot: SMAC/Diablo Antibody (RM271) [NBP2-61586] - HeLa and MCF-7 cells lysates using Anti-Smac/Diablo Rabbit Monoclonal Antibody at a 1:1000 dilution.

Immunohistochemistry-Paraffin: SMAC/Diablo Antibody (RM271) [NBP2-61586]

Immunohistochemistry-Paraffin: SMAC/Diablo Antibody (RM271) [NBP2-61586] - Immunohistochemical staining of formalin fixed and paraffin embedded Human breast cancer tissue sections using NBP2-61586.

Applications for SMAC/Diablo Antibody (RM271)

Application

Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500-1:1000

Western Blot

1:1000-1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SMAC/Diablo

Smac/DIABLO is a mitochondrial protein which activates various forms of apoptosis. Specifically, Smac exits the mitochondria and enters the cytosol where it initiates apoptosis by neutralizing members of the IAP family of apoptosis inhibitory proteins. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms.

Long Name

Second Mitochondria-derived Activator of Caspase

Alternate Names

Diablo

Gene Symbol

DIABLO

Additional SMAC/Diablo Products

Product Documents for SMAC/Diablo Antibody (RM271)

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Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for SMAC/Diablo Antibody (RM271)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Bcl-2 Proteins and Regulators

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