Chemical Name: 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide
Biological ActivitySR 16832 is a dual site PPARγ inhibitor. Acts at orthosteric and allosteric sites in the ligand binding domain. Inhibits binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonists GW 9662 (Cat. No. 1508) and T 0070907 (Cat. No. 2301).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Modification of the othosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor.
Brust et al.
ACS Chem.Biol., 2017;12:969
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