Catalog Number: 3642
Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Biological Activity
Potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.
Technical Data
  • M.Wt:
    373.4
  • Formula:
    C22H19N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    179248-59-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The selectivity of protein kinase inhibitors: a further update.
    Bain et al.
    Biochem.J., 2007;408:297
  2. Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines.
    Tian et al.
    Biochem., 2001;40:7084

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