Src I1

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3642/10
3642/50
Src I1 | CAS No. 179248-59-0 | Src Family Kinase Inhibitors
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Description: Dual site Src kinase inhibitor

Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.

Technical Data

M.Wt:
373.4
Formula:
C22H19N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
179248-59-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The selectivity of protein kinase inhibitors: a further update.
    Bain et al.
    Biochem.J., 2007;408:297
  2. Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines.
    Tian et al.
    Biochem., 2001;40:7084

Product Datasheets

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Reconstitution Calculator

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Citations for Src I1

The citations listed below are publications that use Tocris products. Selected citations for Src I1 include:

2 Citations: Showing 1 - 2

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