Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Biological ActivitySrc I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The selectivity of protein kinase inhibitors: a further update.
Bain et al.
Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines.
Tian et al.
Citations for Src I1
The citations listed below are publications that use Tocris products. Selected citations for Src I1 include:
2 Citations: Showing 1 - 2
CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.
Authors: Zhang Et al.
BMC Immunol 2019;20:7
PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.
Authors: Leung Et al.
J Immunol 2015;194:2930
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