Potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50
values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50
values are 0.32 and 30 μ
M respectively). Can be used in parallel with PP 1
(Cat. No. 1397) and PP 2
(Cat. No. 1407) to inhibit Src family kinases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The selectivity of protein kinase inhibitors: a further update.
Bain et al.
Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines.
Tian et al.