Chemical Name: 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid
Biological ActivityInhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Anti-inflammatory. Induces ferroptosis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer.
Lo et al.
Sulfasalazine for brain cancer fits.
Sontheimer and Bridges
Expert Opin.Invest.Drugs, 2012;21:575
In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasal. in human glioblastomas.
Robe et al.
Clin.Cancer Res., 2004;10:5595
Citations for Sulfasalazine
The citations listed below are publications that use Tocris products. Selected citations for Sulfasalazine include:
2 Citations: Showing 1 - 2
Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.
Authors: Shin Et al.
Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1.
Authors: Yeligar Et al.
J Immunol 2009;183:5964
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