Chemical Name: 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid
Biological ActivityInhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Inhibitor of folate transporter 1 (SLC19A1); inhibits cellular uptake of Methotrexate (Cat. No. 1230) and cyclic dinucleotides, including 2',3'-cGAMP (Cat.No. 5945). Anti-inflammatory. Induces ferroptosis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer.
Lo et al.
Sulfasalazine for brain cancer fits.
Sontheimer and Bridges
Expert Opin.Invest.Drugs, 2012;21:575
In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasal. in human glioblastomas.
Robe et al.
Clin.Cancer Res., 2004;10:5595
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis.
Jansen et al.
Arthritis Rheum., 2004;50:2130
SLC19A1 transports immunoreactive cyclic dinucleotides.
Luteijn et al.
Citations for Sulfasalazine
The citations listed below are publications that use Tocris products. Selected citations for Sulfasalazine include:
2 Citations: Showing 1 - 2
Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.
Authors: Shin Et al.
Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1.
Authors: Yeligar Et al.
J Immunol 2009;183:5964
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