Catalog Number: 4935
Chemical Name: 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid
Biological Activity
Inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Anti-inflammatory. Induces ferroptosis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasalazine in human glioblastomas.
    Robe et al.
    Clin.Cancer Res., 2004;10:5595
  2. Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer.
    Lo et al.
    Curr.Oncol., 2010;17:9
  3. Sulfasalazine for brain cancer fits.
    Sontheimer and Bridges
    Expert Opin.Invest.Drugs, 2012;21:575

The citations listed below are publications that use Tocris products. Selected citations for Sulfasalazine include:

1 Citations: Showing 1 - 1

  1. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1.
    Authors: Yeligar Et al.
    J Immunol 2009;183:5964

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