Sulfasalazine

Tocris Bioscience | Catalog # 4935

Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
Tocris Bioscience

Key Product Details

Description

Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
View all NFkB/IkB Inhibitors »

Product Description

Sulfasalazine is an inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Inhibitor of folate transporter 1 (SLC19A1); inhibits cellular uptake of Methotrexate (Cat. No. 1230) and cyclic dinucleotides, including 2',3'-cGAMP (Cat.No. 5945). Anti-inflammatory. Induces ferroptosis.

Product Specifications for Sulfasalazine

Molecular Weight

398.39

Formula

C18H14N4O5S

Storage

Store at RT

Purity

≥97% (HPLC)

Chemical Name

5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid

CAS Number

599-79-1

PubChem ID

5359476

InChI Key

OQANPHBRHBJGNZ-BKUYFWCQSA-N

SMILES

OC1=CC=C(/N=N/C2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)C=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.84 100

Preparing Stock Solutions for Sulfasalazine

The following data is based on the product molecular weight 398.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.10 mL
5 mM 0.50 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.26 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for Sulfasalazine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Sulfasalazine

For research use only

⚠ WARNING: This product can expose you to chemicals including Sulfasalazine (Salicylazosulfapyridine), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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