Novel, potent, non-competitive AMPA receptor antagonist (IC50
= 2.8 μ
M ). Acts allosterically at the same regulatory site as GYKI 52466 and 53655 and other benzodiazepines but does not bind to the central diazepine binding site. Selective for AMPA relative to kainate receptor sub-types. Similar potency to GYKI 53655. Anticonvulsant in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of Annovis Inc.
Kainate receptor agonists, antagonists and allosteric modulators.
Bleakman et al.
Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord.
Li et al.
Substituted 1,2-dihydrophthalazines: potent, selective and non-competitive inhibitors of the AMPA receptor.
Pelletier et al.
The citations listed below are publications that use Tocris products. Selected citations for SYM 2206 include:
Showing Results 1 - 7 of 7