TAG-72 Antibody (CC49) [PE]

Novus Biologicals | Catalog # NBP2-33128PE

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Rat, Bovine, Canine

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # CC49
View all TAG-72 Primary Antibodies »

Product Specifications

Immunogen

Purified TAG-72 protein

Localization

Cytoplasmic and cell surface

Specificity

Recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This monoclonal antibody defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80% sensitivity and 93% specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of anti-TAG-72 and anti-GCDFP-15 is valuable in the diagnosis of apocrine carcinoma.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for TAG-72 Antibody (CC49) [PE]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 5 using NBP2-33128PE in the following applications:

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: TAG-72

Tumor-associated glycoprotein (TAG-72) is an oncofetal antigen with properties of a mucin. About 60% of carcinoma patients express TAG-72 in their sera. Majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for Ab-1 staining. Weak or no reactivity has been observed with most cell types of normal adult tissue excepting the secretory endometrium. Ab-1 is reportedly useful in distinguishing pulmonary adenocarcinomas (B72.3+) from pleural mesotheliomas (B72.3-).

Alternate Names

CA 72-4, Protein TAG-72, tag 72, tag-72 Protein TAG-72

Additional TAG-72 Products

Product Documents for TAG-72 Antibody (CC49) [PE]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for TAG-72 Antibody (CC49) [PE]

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customer Reviews for TAG-72 Antibody (CC49) [PE] (1)

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Customer Images

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  • TAG-72 Antibody (CC49) [PE]
    Name: Eric Lee
    Application: Flow Cytometry
    Sample Tested: Human ovarian cancer cell lines
    Species: Human
    Verified Customer | Posted 04/26/2022
    Flow cytometric analysis of TAG72 expression on human OVCAR8 (TAG72-), human OVCAR3 (TAG72-positive), human OV90 (TAG72-positive), human OVCAR8-sTn (TAG72-positive) tumor cell lines.
    TAG-72 Antibody (CC49) [PE] NBP2-33128PE

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Protocols

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FAQs for TAG-72 Antibody (CC49) [PE]

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  • Q: I've used your antibodies, NBP2-33128PE, but there are no information of concentration in data sheets and vial label. Please tell me the concentration of NBP2-33128PE antibody. it's lot number is 182875.

    A: For product NBP2-33128PE Lot 182875-2PABX141002-PE the concentration is 0.95mg/ml.

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