Tankyrase binding protein 1 Antibody

Name: Tankyrase binding protein 1 Antibody
Brand: Novus Biologicals
SKU: NB300-988
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NB300-988

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

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Product Specifications

Immunogen

Peptide with sequence KVSTLRESSAMAS-C corresponding to N-Terminus according to NP_203754.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Tankyrase binding protein 1 Antibody

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NB300-988]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NB300-988] - Staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for Tankyrase binding protein 1 Antibody

Application

Recommended Usage

Peptide ELISA

Detection limit 1:64000

Application Notes

WB: Preliminary experiments in human ovary and lung lysates gave no specific signal but low background.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Tankyrase binding protein 1

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Alternate Names

KIAA1741TAB182FLJ45975,182 kDa tankyrase-1-binding protein, tankyrase 1 binding protein 1, 182kDa, tankyrase 1-binding protein of 182 kDa

Entrez Gene IDs

85456 (Human)

Gene Symbol

TNKS1BP1

UniProt

NP_203754. (Human)

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Product Specific Notices for Tankyrase binding protein 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Tankyrase binding protein 1 Antibody

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