Tau [p Ser262] Antibody

Name: Tau [p Ser262] Antibody
Brand: Novus Biologicals
SKU: NB100-82242
Price: 369 USD
Availability: InStock
Rating: 3 (1 reviews)

Novus Biologicals | Catalog # NB100-82242

(1)

Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Simple Western

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

View all Tau Primary Antibodies »

Product Specifications

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 262 (I-G-SP-T-E).

Modification

p Ser262

Marker

pan-Neuronal Marker

Specificity

Detects endogenous levels of Tau only when phosphorylated at serine 262.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit Tau [p Ser262] Antibody (NB100-82242) is a polyclonal antibody validated for use in WB and Simple Western. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Tau [p Ser262] Antibody

Simple Western: Tau [p Ser262] Antibody [NB100-82242]

Simple Western: Tau [p Ser262] Antibody [NB100-82242] - Simple western analysis of mouse brain tissue (striatum) from 4 month old Tg4150 and wildtype mice. Image courtesy of Dr. Brandi Wasek-Patterson at Baylor Research Institute, Institute of Metabolic Disease.

Western Blot: Tau [p Ser262] Antibody [NB100-82242] -

Western Blot: Tau [p Ser262] Antibody [NB100-82242] - Western blot analysis of lysates from HeLa cells, using NB100-82242. The lane on the left is blocked with the phospho peptide.

Applications for Tau [p Ser262] Antibody

Application

Recommended Usage

Western Blot

1:500-1:2000

Application Notes

See Simple Western Antibody Database for Simple Western validation: Tested in Mouse brain tissue (striatum) from 4 month old Tg4150 and wild-type mice, separated by Size

Reviewed Applications

Read 1 review rated 3 using NB100-82242 in the following applications:

Simple Western (1 Review)

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% glycerol, 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Tau

Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.

Long Name

Microtubule-Associated Protein Tau

Alternate Names

MAPT, MSTD, MTBT1, Neurofibrillary tangle protein, PPND

Entrez Gene IDs

4137 (Human); 17762 (Mouse); 29477 (Rat)

Gene Symbol

MAPT

UniProt

P10636

Additional Tau Products

Product Documents for Tau [p Ser262] Antibody

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Product Specific Notices for Tau [p Ser262] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cancer Biomarkers

Diabetic Peripheral Neuropathy

Microtubules

Neuronal Lineage Markers

Neuronal Markers

Customer Reviews for Tau [p Ser262] Antibody (1)

3 out of 5

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Name: Anonymous

Application: Simple Western

Sample Tested:

Species: Mouse

Verified Customer | Posted 08/05/2015

Simple western analysis of mouse brain tissue (striatum) from 4 month old Tg4150 and wildtype mice.

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