Catalog Number: 2737
Chemical Name: 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate
Biological Activity
Subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors.
    Bencherif et al.
    Eur.J.Pharmacol., 2000;409:45
  2. The nicotinic α4β2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices.
    Chen et al.
    Neuropharmacology, 2003;45:334
  3. 5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors.
    Zwart et al.
    Eur.J.Pharmacol., 2006;539:10

The citations listed below are publications that use Tocris products. Selected citations for TC 2559 difumarate include:

Showing Results 1 - 1 of 1

  1. Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals.
    Authors: Sun Et al.
    Mol Cancer Ther
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