TC 2559 difumarate

Key Product Details

Product Description

TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC₅₀ values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)₂(β2)₃ receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.

Product Specifications for TC 2559 difumarate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TC 2559 difumarate

The following data is based on the product molecular weight 438.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.81 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Chen The nicotinic α4β2 receptor selective agonist, TC-2559, increases DA neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology 2003 PMID: 12871651
• Zwart 5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors. Eur.J.Pharmacol. 2006 PMID: 16674940
• Bencherif TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur.J.Pharmacol. 2000 PMID: 11099699

Product Documents for TC 2559 difumarate