Subtype-selective partial agonist for α
2 nicotinic acetylcholine receptors (EC50
values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μ
M for α
2 and α
7 receptor subtypes respectively). Displays selectivity for (α
receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.
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All Tocris products are intended for laboratory research use only.
TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors.
Bencherif et al.
The nicotinic α4β2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices.
Chen et al.
5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors.
Zwart et al.
The citations listed below are publications that use Tocris products. Selected citations for TC 2559 difumarate include:
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