TCS 1102

  ( 5 citations )    
Product Datasheet
Catalog Number:3818
Chemical Name:N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
Product Details
Citations (5)
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Reviews
Biological Activity
Potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.
Technical Data
  • M.Wt:
    470.59
  • Formula:
    C27H26N4O2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    916141-36-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)
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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Mouse Orexin R2/HCRTR2 (NP_945200) VersaClone cDNA

RDC0617
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Mouse Orexin R1/HCRTR1 (NP_945197) VersaClone cDNA

RDC0616
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Human Orexin R1/HCRTR1 (AAC39601) VersaClone cDNA

RDC0521
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Human Orexin R2/HCRTR2 (AAC39602) VersaClone cDNA

RDC0522
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