Potent, dual orexin receptor antagonist (Ki
values are 0.2 and 3 nM for OX2
receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo
. Brain penetrant.
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Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.
Winrow et al.
Proline bis-amides as potent dual orexin receptor antagonists.
Bergman et al.
The citations listed below are publications that use Tocris products. Selected citations for TCS 1102 include:
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