TCS 1102

Catalog # Availability Size / Price Qty
3818/10
3818/50
Cat.No. 3818 - TCS 1102 | C27H26N4O2S | CAS No. 916141-36-1
1 Image
Description: Potent, dual orexin receptor antagonist

Chemical Name: N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

Purity: ≥98%

Product Details
Citations (5)
Supplemental Products
Reviews

Biological Activity

Potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.

Technical Data

M.Wt:
470.59
Formula:
C27H26N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
916141-36-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Background References

  1. The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking.
    Khoo et al.
    PLoS One, 2017;12:e0173967
  2. Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.
    Winrow et al.
    Neuropharmacology, 2010;58:185
  3. Proline bis-amides as potent dual orexin receptor antagonists.
    Bergman et al.
    Bioorg.Med.Chem.Letts, 2008;18:1425

Product Datasheets

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