Orexin A (human, rat, mouse)

  ( 9 citations )    
Product Datasheet
Catalog Number:1455
Chemical Name:
Product Details
Citations (9)
Reviews
Biological Activity
Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.
Technical Data
  • M.Wt:
    3561.12
  • Formula:
    C152H243N47O44S4
  • Sequence:
    XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL

    (Modifications: X = Glp, Disulfide bridge between 6 - 12, 7 - 14, Leu-33 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    205640-90-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:

9 Citations: Showing 1 - 9
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  1. The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking.
    Authors: Khoo Et al.
    PLoS One  2017;12
  2. Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells.
    Authors: Kim Et al.
    Brain Res  2015;19:327
  3. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals.
    Authors: Shu Et al.
    PLoS One  2014;9:e95259
  4. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res  2012;318:2004
  5. Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats.
    Authors: Lungwitz Et al.
    Physiol Behav  2012;107:726
  6. Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences.
    Authors: Moorman and Aston-Jones
    J Neurosci  2010;30:15585
  7. Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.
    Authors: Burdyga Et al.
    Am J Physiol Gastrointest Liver Physiol  2010;299:G63
  8. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.
    Authors: Gompf and Aston-Jones
    J Pharmacol Exp Ther  2008;1224:43
  9. Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
    Authors: Holland Et al.
    Korean J Physiol Pharmacol  2005;315:1380

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