Catalog Number: 1455
Biological Activity
Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: X = Glp, Disulfide bridge between 6 - 12, 7 - 14, Leu-33 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.
    Kilduff and Peyron
    TiNS, 2000;23:359
  2. Orexins: a new family of neuropeptides.
    Br.J.Anaesth., 1999;83:695
  3. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour.
    Sakurai et al.
    Cell, 1998;92:573

The citations listed below are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:

Showing Results 1 - 5 of 5

  1. Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells.
    Authors: Kim Et al.
    Brain Res
  2. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res
  3. Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences.
    Authors: Moorman and Aston-Jones
    J Neurosci
  4. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.
    Authors: Gompf and Aston-Jones
    J Pharmacol Exp Ther
  5. Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
    Authors: Holland Et al.
    Korean J Physiol Pharmacol
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