Orexin A (human, rat, mouse)

Catalog # Availability Size / Price Qty
Orexin A (human, rat, mouse)
1 Image
Description: Endogenous agonist at OX1 and OX2

Purity: ≥95%

Product Details
Citations (11)

Biological Activity

Orexin A (human, rat, mouse) is an endogenous agonist with high affinity at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Orexin A stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin A impairs neurogenesis and hippocampal plasticity in mice. Orexin A improves glucose control and beta cell functions in type 2 diabetic animals.

Technical Data


(Modifications: X = Glp, Disulfide bridges: 6-12, 7-14, Leu-33 = C-terminal amide)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Orexin A (human, rat, mouse)

The citations listed below are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:

11 Citations: Showing 1 - 10

  1. Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice.
    Authors: Forte Et al.
    Nat.Commun.  2021;12:6137
  2. The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking.
    Authors: Khoo Et al.
    PLoS One  2017;12
  3. Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors.
    Authors: Kim and Han
    Exp Neurobiol  2016;25:307
  4. Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells.
    Authors: Kim Et al.
    Brain Res  2015;19:327
  5. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals.
    Authors: Shu Et al.
    PLoS One  2014;9:e95259
  6. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res  2012;318:2004
  7. Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats.
    Authors: Lungwitz Et al.
    Physiol Behav  2012;107:726
  8. Orexin/hypocretin modulates response of ventral tegmental DA neurons to prefrontal activation: diurnal influences.
    Authors: Moorman and Aston-Jones
    J Neurosci  2010;30:15585
  9. Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.
    Authors: Burdyga Et al.
    Am J Physiol Gastrointest Liver Physiol  2010;299:G63
  10. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.
    Authors: Gompf and Aston-Jones
    J Pharmacol Exp Ther  2008;1224:43


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