Biological ActivityEndogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.
(Modifications: X = Glp, Disulfide bridge between 6 - 12, 7 - 14, Leu-33 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.
Kilduff and Peyron
Orexins: a new family of neuropeptides.
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour.
Sakurai et al.
Citations for Orexin A (human, rat, mouse)
The citations listed below are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:
9 Citations: Showing 1 - 9
The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking.
Authors: Khoo Et al.
PLoS One 2017;12
Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells.
Authors: Kim Et al.
Brain Res 2015;19:327
Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals.
Authors: Shu Et al.
PLoS One 2014;9:e95259
OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
Authors: Guo and Feng
Exp Cell Res 2012;318:2004
Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats.
Authors: Lungwitz Et al.
Physiol Behav 2012;107:726
Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences.
Authors: Moorman and Aston-Jones
J Neurosci 2010;30:15585
Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.
Authors: Burdyga Et al.
Am J Physiol Gastrointest Liver Physiol 2010;299:G63
Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.
Authors: Gompf and Aston-Jones
J Pharmacol Exp Ther 2008;1224:43
Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
Authors: Holland Et al.
Korean J Physiol Pharmacol 2005;315:1380
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