Orexin A (human, rat, mouse)

Tocris Bioscience | Catalog # 1455

Endogenous agonist at OX1 and OX2
Tocris Bioscience

Key Product Details

Description

Endogenous agonist at OX1 and OX2
View all Orexin Receptor Agonists »

Product Description

Orexin A (human, rat, mouse) is an endogenous agonist with high affinity at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Orexin A stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin A impairs neurogenesis and hippocampal plasticity in mice. Orexin A improves glucose control and beta cell functions in type 2 diabetic animals.

Product Specifications for Orexin A (human, rat, mouse)

Molecular Weight

3561.12

Formula

C152H243N47O44S4

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

205640-90-0

PubChem ID

90470982

InChI Key

IXODJSWYPSZUCI-IIIOAANCSA-N

SMILES

[H]N1[C@@H](CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC1=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

Product Documents for Orexin A (human, rat, mouse)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Orexin A (human, rat, mouse)

For research use only

Citations for Orexin A (human, rat, mouse)

Customer Reviews for Orexin A (human, rat, mouse) (1)

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  • ICV injection in rats
    Name: Chris Holton
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 05/31/2020
    ICV injection of orexin A at 20, 63 and 600 pmol in 2 uL aCSF in male Sprague Dawley rats under propofol anesthesia. Measurement of extracellular neuronal cell firing from the locus coeruleus. Clonidine 0.1 mg/kg i.p.
    Orexin A (human, rat, mouse) 1455

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