Temsirolimus

Catalog # Availability Size / Price Qty
5264/10
Temsirolimus | CAS No. 162635-04-3 | mTOR Inhibitors
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Description: mTOR inhibitor; antitumor
Alternative Names: CCI-779

Chemical Name: Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.

Technical Data

M.Wt:
1030.29
Formula:
C56H87NO16
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
162635-04-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for Temsirolimus

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2 Citations: Showing 1 - 2

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