Chemical Name:Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
Biological Activity mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C
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