Chemical Name: Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
Biological ActivityTemsirolimus is a mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of mammalian target of rapamycin signaling by CCI-779 (temsirolimus) induces growth inhibition and cell cycle arrest in Cashmere goat fetal fibroblasts (Capra hircus).
Wang et al.
DNA Cell Biol., 2012;31:1095
Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts.
Wu L et al.
Cancer Res., 2005;65:2825
The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells.
Li et al.
Cancer Cell Int., 2013;13
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsiro.
Del Bufalo et al.
Cancer Res., 2006;66:5549
Citations for Temsirolimus
The citations listed below are publications that use Tocris products. Selected citations for Temsirolimus include:
2 Citations: Showing 1 - 2
In vivo brain GPCR signaling elucidated by phosphoproteomics.
Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms.
Authors: Olmez Et al.
Clin Cancer Res 2017;23:6958
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