Thymidylate Synthase Antibody (TYMS/9091R)

Novus Biologicals | Catalog # NBP3-23732

Recombinant Monoclonal Antibody
Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # TYMS/9091R
View all Thymidylate Synthase Primary Antibodies »

Product Specifications

Immunogen

Recombinant human Thymidylate Synthase protein fragment (around aa 1-200) (exact sequence is proprietary)

Localization

Nucleus. Cytoplasm.

Marker

5-FU Resistance Marker

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Description

Store at 2 to 8C. Non-hazardous. No MSDS required.

Scientific Data Images for Thymidylate Synthase Antibody (TYMS/9091R)

Thymidylate Synthase Antibody (TYMS/9091R) Immunohistochemistry-Paraffin: Thymidylate Synthase Antibody (TYMS/9091R) [NBP3-23732] -

Immunohistochemistry-Paraffin: Thymidylate Synthase Antibody (TYMS/9091R) [NBP3-23732] -

Immunohistochemistry-Paraffin: Thymidylate Synthase Antibody (TYMS/9091R) [NBP3-23732] - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Thymidylate Synthase Antibody (TYMS/9091R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
Thymidylate Synthase Antibody (TYMS/9091R) Immunohistochemistry-Paraffin: Thymidylate Synthase Antibody (TYMS/9091R) [NBP3-23732] -

Immunohistochemistry-Paraffin: Thymidylate Synthase Antibody (TYMS/9091R) [NBP3-23732] -

Immunohistochemistry-Paraffin: Thymidylate Synthase Antibody (TYMS/9091R) [NBP3-23732] - IHC analysis of formalin-fixed, paraffin-embedded human brain. Negative tissue control using Thymidylate Synthase Antibody (TYMS/9091R) at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Applications for Thymidylate Synthase Antibody (TYMS/9091R)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml
Application Notes
Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Thymidylate Synthase

Thymidylate synthase (TS) is an intracellular enzyme critical for de novo synthesis of DNA. In cancer, expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time.

Long Name

Thymidylate synthase

Alternate Names

EC 2.1.1.45, OK/SW-cl.29, TS, TSase, TYMS

Gene Symbol

TYMS

Additional Thymidylate Synthase Products

Product Documents for Thymidylate Synthase Antibody (TYMS/9091R)

Certificate of Analysis

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Product Specific Notices for Thymidylate Synthase Antibody (TYMS/9091R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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