TMPRSS3 Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-45181

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all TMPRSS3 Primary Antibodies »

Product Specifications

Immunogen

transmembrane protease, serine 3. (Uniprot# P57727)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit TMPRSS3 Antibody - BSA Free (NBP3-45181) is a polyclonal antibody validated for use in IHC and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for TMPRSS3 Antibody - BSA Free

TMPRSS3 Antibody - BSA Free

Immunohistochemistry: TMPRSS3 Antibody - BSA Free [NBP3-45181] -

Immunohistochemistry: TMPRSS3 Antibody - BSA Free [NBP3-45181] - Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using (TMPRSS3 antibody) at dilution of 1:50

Applications for TMPRSS3 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:20-1:200

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% Glycerol, pH (7.3)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TMPRSS3

Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS3 (also known as ECHOS1) gene, which encodes a transmembrane serine protease, has been found to be responsible for two non-syndromic recessive deafness loci located on human chromosome 21q22.3, DFNB8 and DFNB10.TMPRSS3, a 437 amno acid membrane bound serine protease and a member of the S1 peptidase family. TMPRSS3 contains an amino-terminal signalanchor sequence and a glycosylated extracellular region containing the serine protease domain. Two novel missense mutations of TMPRSS3, W251C and P404L, alter the highly conserved amino acids of the serine protease domain. TMPRSS3 is expressed in many tissues, including fetal cochlea, a subset of pancreatic cancer and various other cancer tissues. TMPRSS3 is also overexpressed in cancer, suggesting that it may be important for processes in metastasis formation and tumor invasion.

Long Name

TransmembraneSerine Protease 3

Alternate Names

DFNB10, DFNB8, ECHOS1, TADG12

Gene Symbol

TMPRSS3

Additional TMPRSS3 Products

Product Documents for TMPRSS3 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for TMPRSS3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Serine Proteases and Regulators

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Protocols

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