Tocrifluor T1117

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Tocrifluor T1117 | CAS No. 1186195-59-4 | Cannabinoid R1/CB1 Receptor Ligand
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Description: Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117)

Chemical Name: N-(Piperidin-1-yl)-5-(4-(4-(3-(5-carboxamidotetramethylrhodaminyl)propyl))phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

Purity: ≥95%

Product Details
Citations (3)
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Biological Activity

Tocrifluor T1117 is a fluorescent form of AM 251. AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Displays GPR55 binding activity. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.

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Optical Data for Tocrifluor T1117

λabs 543 nm
λem 590 nm
Application Fluorescence Microscopy, Confocal Microscopy

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Technical Data

Soluble to 10 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Background References

  1. Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay.
    Bruno et al.
    Sci.Rep., 2014;4:3757
  2. Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses.
    Sylantyev et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:5193
  3. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.
    Daly et al.
    Br.J.Pharmacol., 2010;159:787
  4. Visualisation of vascular cannabinoid receptors and their potential interaction with α1-adrenergic receptors.
    Daly et al.
    Vascular and Smooth Muscle Phys.Soc. Symposium, 2008;

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Citations for Tocrifluor T1117

The citations listed below are publications that use Tocris products. Selected citations for Tocrifluor T1117 include:

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