Catalog Number: 2540
Chemical Name: N-(Piperidin-1-yl)-5-(4-(4-(3-(5-carboxamidotetramethylrhodaminyl)propyl))phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Biological Activity
Fluorescent form of AM 251. AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Displays GPR55 binding activity.

View more information regarding Tocrifluor T1117.

Technical Data
  • M.Wt:
    974.97
  • Formula:
    C56H53Cl2N7O5
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    1186195-59-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay.
    Bruno et al.
    Sci.Rep., 2014;4:3757
  2. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.
    Daly et al.
    Br.J.Pharmacol., 2010;159:787
  3. Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses.
    Sylantyev et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:5193
  4. Visualisation of vascular cannabinoid receptors and their potential interaction with α1-adrenergic receptors.
    Daly et al.
    Vascular and Smooth Muscle Phys.Soc. Symposium, 2008;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tocrifluor T1117 include:

2 Citations: Showing 1 - 2
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  1. Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides.
    Authors: Tortoriello Et al.
    PLoS One 2013;8:e67865
  2. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.
    Authors: Daly Et al.
    Br J Pharmacol 2010;159:787
Tocris Small Molecules
Description Application Cat# Citations Images  

AM 251

1117 114  
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