receptor antagonist (IC
= 8 nM, K
= 7.49 nM) that displays 306-fold selectivity over CB
receptors. Also potent GPR55 agonist (EC
= 39 nM).
Fluorescent Form also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products.
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Feeding induced by cannabinoids is mediated independently of the melanocortin system.
Authors: Sinnayah Et al.
Proc Natl Acad Sci U S A ;3:e2202
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system.
Authors: Kola Et al.
Br J Pharmacol ;3:e1797
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
Authors: Lafourcade Et al.
PLoS One ;2:e709
Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
Authors: Jiang Et al.
PLoS One ;2:e641
Involvement of cannabinoid system in the nucleus accumbens on delay-based decision making in the rat.
Behav Brain Res. 2017;337:107
Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
Brain Res 2017;1663:132
AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity.
J Neuroinflammation 2017;14(1):246
AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids.
Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression.
PLoS One 2017;12(7):e0182141
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Authors: Cui Et al.
Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment.
Authors: Krohn Et al.
J Inflamm (Lond) 2016;13:21
Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors.
Authors: Blaha Et al.
PLoS One 2016;11:e0157424
Δ 9-Tetrahydrocannabinol Reverses TNFα-induced Increase in Airway Epithelial Cell Permeability through CB 2 Receptors
Authors: Shang Et al.
Biochemical Pharmacology 2016;
Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
Authors: Martin Et al.
Br J Pharmacol 2015;9:457
Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals.
Authors: Lenkey Et al.
Sci Rep 2015;6:6557
FAAH genetic variation enhances fronto-amygdala function in mouse and human.
Authors: Dincheva Et al.
Nat Commun 2015;6:6395
Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
Authors: Zhou Et al.
Nat Commun 2015;64:32
Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons.
Authors: Vähätalo Et al.
Mol Cell Neurosci 2015;5:e151
Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected].
Authors: Krishnan and Chatterjee
PLoS One 2015;5:9887
Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice.
Authors: Liu Et al.
Nutr Diabetes 2015;5:9490
Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
Authors: Parvathy and Masocha
J Neurosci 2015;5:10541
Activation of cannabinoid receptor 1 inhibits increased bladder activity induced by nerve growth factor.
Authors: Wang Et al.
Neurosci Lett 2015;589:19
Cannabinoid receptor CB2 is involved in tetrahydrocannabinol-induced anti-inflammation against lipopolysaccharide in MG-63 cells.
Authors: Yang Et al.
Sci Rep 2015;2015:362126
Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
Authors: Malek Et al.
Neural Plast 2015;2015:130639
Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation.
Authors: Bashashati Et al.
Br J Pharmacol 2015;172:3099
A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome.
Authors: Bowles Et al.
Mol Pharmacol 2015;112:285
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.
Authors: Arrabal Et al.
PLoS One 2015;10:e0145244
Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
Authors: Zhang Et al.
PLoS One 2015;10:e0142160
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
Authors: Smith Et al.
Proc Natl Acad Sci U S A 2015;10:e0136546
Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.
Authors: Stanley Et al.
Front Cell Neurosci 2015;107:568
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
Authors: Alpár Et al.
J Neurosci 2014;5:4421
Presynaptic calcium channel inhibition underlies CB1 cannabinoid receptor-mediated suppression of GABA release.
Authors: Szabó Et al.
Mediators Inflamm 2014;34:7958
Hippocampal metaplasticity is required for the formation of temporal associative memories.
Authors: Xu Et al.
J Neurosci 2014;34:16762
Miswiring the brain: △9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.
Authors: Tortoriello Et al.
Proc Natl Acad Sci U S A 2014;33:668
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex.
Authors: Cass Et al.
Mol Psychiatry 2014;19:536
CB1 cannabinoid receptors are involved in neuroleptic-induced enhancement of brain neurotensin.
Authors: Hassanzadeh and Rostami
J Neurosci 2014;17:181
Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes.
Authors: Kury Et al.
Br J Pharmacol 2014;171:3485
2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells.
Authors: Costa Et al.
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
Authors: Benz Et al.
PLoS One 2013;8:e81675
Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH.
Authors: Chanda Et al.
PLoS One 2013;8:e68845
Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
Authors: Cao Et al.
PLoS One 2013;7:e52921
The cannabinoid δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.
Authors: Wargent Et al.
Nutr Diabetes 2013;3:e68
Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling.
Authors: Keimpema Et al.
Nat Commun 2013;3:2093
Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory.
Authors: Abush and Akirav
Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.
Authors: Duncan Et al.
Am J Physiol Regul Integr Comp Physiol 2013;305:R224
CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
Authors: Malenczyk Et al.
J Biol Chem 2013;288:32685
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
Authors: Li Et al.
Br J Pharmacol 2013;170:489
Gene-environment interactions affect long-term depression (LTD) through changes in dopamine receptor affinity in Snap25 deficient mice.
Authors: Baca Et al.
Brain Res 2013;1532:85
Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.
BMC Neurosci 2013;14:20
The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Authors: Sreevalsan and Safe
Mol Cancer Ther 2013;12:2483
Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
Authors: Guida Et al.
Mol Pain 2012;8:60
Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.
Authors: Brents Et al.
Biochem Pharmacol 2012;83:952
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors.
Authors: Tauber Et al.
PLoS One 2012;7:e48272
CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation.
Authors: Laricchiuta Et al.
PLoS One 2012;7:e42111
A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
Authors: Tozzi Et al.
PLoS One 2012;7:e38312
Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
Authors: Laricchiuta Et al.
PLoS One 2012;7:e33260
A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion.
Authors: Sideris Et al.
Front Neurosci 2012;6:4
Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
Authors: Casarotto Et al.
Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.
Authors: Ganon-Elazar and Akirav
On disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment.
Authors: Stern Et al.
Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
Authors: Peterfi Et al.
J Neurosci 2012;32:14448
Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.
Authors: Gonzalez-Islas Et al.
Sci Rep 2012;32:13597
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene.
Authors: Chanda Et al.
Br J Pharmacol 2012;287:38041
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
Authors: Tumati Et al.
J Neuroimmunol 2012;244:23
TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception.
Authors: Giordano Et al.
Cereb Cortex 2012;22:2495
Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide.
Authors: Merighi Et al.
Br J Pharmacol 2012;165:1773
Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
Authors: Niu Et al.
J Pharmacol Exp Ther 2012;153:2283
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
Authors: Liu Et al.
Mol Cancer Ther 2012;11:1421
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats.
Authors: Novellis Et al.
Mol Pain 2011;7:7
The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids.
Authors: Negrete Et al.
PLoS One 2011;6:e26688
Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes.
Authors: Ruby Et al.
PLoS One 2011;6:e26415
Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.
Authors: Brents Et al.
PLoS One 2011;6:e21917
Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade.
Authors: Crespillo Et al.
Biochem J 2011;433:175
Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory.
Authors: Sousa Et al.
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice.
Authors: Pan Et al.
J Cell Biol 2011;31:13420
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
Authors: Li and Burrell
Learn Mem 2011;18:545
Differential effects of cannabinoid receptor agonist on social discrimination and contextual fear in amygdala and hippocampus.
Authors: Segev and Akirav
Learn Mem 2011;18:254
The Role of the Endocannabinoids in Suppression of the Hypothalamic-pituitary-adrenal Axis Activity by Doxepin.
Authors: Hassanzadeh and Hassanzadeh
J Leukoc Biol 2011;14:414
Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine.
Authors: Guidali Et al.
Int J Neuropsychopharmacol 2011;14:17
Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray.
Authors: Samineni Et al.
Brain Res 2011;1389:177
Endocannabinoids mediate synaptic plasticity at glutamatergic synapses on spiny neurons within a basal ganglia nucleus necessary for song learning.
Authors: Thompson and Perkel
J Neurophysiol 2011;105:1159
The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period.
Authors: Jiang Et al.
THC Prevents MDMA Neurotoxicity in Mice.
Authors: Touriño Et al.
PLoS One 2010;5:e9143
The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages.
Authors: Hao Et al.
Iran J Basic Med Sci 2010;51:2181
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
Authors: Jones Et al.
Cereb Cortex 2010;332:569
A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
Authors: Buznikov Et al.
Dev Neurosci 2010;32:1
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure.
Authors: Huang Et al.
J Neurosci 2010;30:16636
Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus.
Authors: Wamsteeker Et al.
J Neurosci 2010;30:11188
Cannabinoids excite circadian clock neurons.
Authors: Acuna-Goycolea Et al.
J Neurosci 2010;30:10061
Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.
Authors: Bhaskaran and Smith
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
Authors: Mair Et al.
Br J Pharmacol 2010;161:176
Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.
Authors: Ho Et al.
GPR55 ligands promote receptor coupling to multiple signalling pathways.
Authors: Henstridge Et al.
Br J Pharmacol 2010;160:604
Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain.
Authors: Curto-Reyes Et al.
Br J Pharmacol 2010;160:561
Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons.
Authors: Farkas Et al.
J Biol Chem 2010;151:5818
Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic.
Authors: Atkinson Et al.
Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons.
Authors: Losonczy Et al.
Nat Neurosci 2010;13:967
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.
Authors: Schlosburg Et al.
Nat Neurosci 2010;13:1113
Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
Authors: Yuan and Burrell
J Neurophysiol 2010;104:2766
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
Authors: Garzón Et al.
Mol Pain 2009;5:11
PKCε regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2.
Authors: Wallace Et al.
Iran J Basic Med Sci 2009;34:1733
The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice.
Authors: Meuth Et al.
Exp Neurol 2009;33:42675
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
Authors: Pan Et al.
J Pharmacol Exp Ther 2009;331:591
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Authors: Pacheco Et al.
Br J Pharmacol 2009;158:225
Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
Authors: Mendiguren and Pineda
Br J Pharmacol 2009;158:1579
Endogenous cannabinoids induce fever through the activation of CB1 receptors.
Authors: Fraga Et al.
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Authors: Ho and Gardiner
Br J Pharmacol 2009;156:94
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
Authors: Tjen-A-Looi Et al.
J Appl Physiol (1985) 2009;106:1793
Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice.
Authors: Toscano Et al.
Brain Res Bull 2008;75:598
Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes.
Authors: Börner Et al.
Eur J Pharmacol 2008;73:1013
Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.
Authors: Georgieva Et al.
Br J Pharmacol 2008;581:19
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Authors: Gibson Et al.
Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent morphine antinociception.
Authors: Wilson Et al.
Cannabinoid receptor activation in the nucleus tractus solitaries produces baroreflex-like responses in the rat.
Authors: Durakoglugil and Orer
Int J Biomed Sci 2008;4:229
Dichotomous dopaminergic control of striatal synaptic plasticity.
Authors: Shen Et al.
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
Authors: Melis Et al.
J Neurosci 2008;28:13985
Electroacupuncture of 2?hz has a rewarding effect: evidence from a conditioned place preference study in rats.
Authors: Xia Et al.
Evid Based Complement Alternat Med 2008;2011:730514
Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
Authors: Desroches Et al.
Eur J Neurosci 2008;155:913
MDA7: a novel selective agonist for CB2 receptors that prevents allodynia in rat neuropathic pain models.
Authors: Naguib Et al.
Br J Pharmacol 2008;155:1104
Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.
Authors: Giannini Et al.
Br J Pharmacol 2008;12:2381
The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms.
Authors: Potenzieri Et al.
Brain Res 2008;1215:69
Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins.
Authors: Ruby Et al.
Proc Natl Acad Sci U S A 2008;105:14561
Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis.
Authors: Rajesh Et al.
Cardiovasc Res 2007;82:1382
The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
Authors: Saitoh Et al.
J Neurosci 2007;570:182
Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids.
Authors: Cachope Et al.
Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
Authors: Kelm Et al.
PLoS One 2007;323:356
Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.
Authors: Bátkai Et al.
Br J Pharmacol 2007;293:H1689
Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal.
Authors: Huang Et al.
J Neurosci 2007;27:4870
Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors.
Authors: Makara Et al.
J Neurosci 2007;27:10211
Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons.
Authors: Fortin and Levine
J Biol Chem 2007;17:163
Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats.
Authors: Ghasemi Et al.
EMBO J 2007;151:591
Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation.
Authors: Hoffman Et al.
Learn Mem 2007;14:63
Cannabinoid action in the olfactory epithelium.
Authors: Czesnik Et al.
Proc Natl Acad Sci U S A 2007;104:2967
Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex.
Authors: Crozier Et al.
Proc Natl Acad Sci U S A 2007;104:1383
Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
Authors: Wang Et al.
Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils.
Authors: Kurihara Et al.
Br J Pharmacol 2006;281:12908
Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus.
Authors: Derbenev Et al.
PLoS One 2006;26:9666
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
Authors: Bender Et al.
J Neurosci 2006;26:4166
Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.
Authors: Cenni Et al.
Eur J Neurosci 2006;24:1633
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
Authors: Moezi Et al.
J Neurosci 2006;149:898
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
Authors: Jayamanne Et al.
J Neurosci 2006;147:281
Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle.
Authors: Lin Et al.
Learn Mem 2006;13:316
Amnestic effect of intrahippocampal AM251, a CB1-selective blocker, in the inhibitory avoidance, but not in the open field habituation task, in rats.
Authors: de Oliveira Alvares Et al.
Neurobiol Learn Mem 2005;83:119
Endocannabinoids control the induction of cerebellar LTD.
Authors: Safo and Regehr
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.
Authors: Pacher Et al.
J Lipid Res 2005;289:H533
Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.
Authors: Hoffman Et al.
Am J Physiol Heart Circ Physiol 2005;22:2387
Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats.
Authors: Gaskari Et al.
Sci Rep 2005;146:315
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.
Authors: Berghuis Et al.
Neurobiol Dis 2005;102:19115
Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.
Authors: Jin Et al.
Am J Physiol Heart Circ Physiol 2004;66:204
Endocannabinoid-mediated metaplasticity in the hippocampus.
Authors: Chevaleyre and Castillo
The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids.
Authors: Vannacci Et al.
J Pharmacol Exp Ther 2004;311:256
Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors.
Authors: Galarreta Et al.
J Pharmacol Exp Ther 2004;24:9770
Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.
Authors: Harkany Et al.
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
Authors: Melyan Et al.
J Neurosci 2004;24:4530
Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
Authors: Price Et al.
Br J Pharmacol 2004;142:257
Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors.
Authors: Akerman Et al.
Br J Pharmacol 2004;142:1354
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Authors: Mathison Et al.
Br J Pharmacol 2004;142:1247
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Authors: Bátkai Et al.
Eur J Pharmacol 2004;110:1996
The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen.
Authors: Scorticati Et al.
Mol Pharmacol 2004;101:11891
The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
Authors: Williams Et al.
J Cell Mol Med 2003;160:481
An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
Authors: Savinainen Et al.
Br J Pharmacol 2003;140:1451
Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts.
Authors: Ford Et al.
Br J Pharmacol 2002;135:1191
Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes.
Authors: Savinainen Et al.
Br J Pharmacol 2001;134:664
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Authors: Stanford Et al.
Br J Pharmacol 2001;133:825
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