Catalog Number: 1117
Chemical Name: N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
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114 Citations: Showing 1 - 10
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  1. Feeding induced by cannabinoids is mediated independently of the melanocortin system.
    Authors: Sinnayah Et al.
    Proc Natl Acad Sci U S A ;3:e2202
  2. The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system.
    Authors: Kola Et al.
    Br J Pharmacol ;3:e1797
  3. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
    Authors: Lafourcade Et al.
    PLoS One ;2:e709
  4. Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
    Authors: Jiang Et al.
    PLoS One ;2:e641
  5. Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
    Authors: Han
    Brain Res 2017;1663:132
  6. AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids.
    Authors: King-Himmelreich
    Neuropharmacology 2017;124:134
  7. Δ 9-Tetrahydrocannabinol Reverses TNFα-induced Increase in Airway Epithelial Cell Permeability through CB 2 Receptors
    Authors: Shang Et al.
    Biochemical Pharmacology 2016;
  8. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
    Authors: Martin Et al.
    Br J Pharmacol 2015;9:457
  9. Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals.
    Authors: Lenkey Et al.
    Sci Rep 2015;6:6557
  10. FAAH genetic variation enhances fronto-amygdala function in mouse and human.
    Authors: Dincheva Et al.
    Nat Commun 2015;6:6395
  11. Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
    Authors: Zhou Et al.
    Nat Commun 2015;64:32
  12. Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons.
    Authors: Vähätalo Et al.
    Mol Cell Neurosci 2015;5:e151
  13. Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected].
    Authors: Krishnan and Chatterjee
    PLoS One 2015;5:9887
  14. Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice.
    Authors: Liu Et al.
    Nutr Diabetes 2015;5:9490
  15. Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
    Authors: Parvathy and Masocha
    J Neurosci 2015;5:10541
  16. Cannabinoid receptor CB2 is involved in tetrahydrocannabinol-induced anti-inflammation against lipopolysaccharide in MG-63 cells.
    Authors: Yang Et al.
    Sci Rep 2015;2015:362126
  17. Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
    Authors: Malek Et al.
    Neural Plast 2015;2015:130639
  18. A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome.
    Authors: Bowles Et al.
    Mol Pharmacol 2015;112:285
  19. Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
    Authors: Zhang Et al.
    PLoS One 2015;10:e0142160
  20. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
    Authors: Smith Et al.
    Proc Natl Acad Sci U S A 2015;10:e0136546
  21. Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.
    Authors: Stanley Et al.
    Front Cell Neurosci 2015;107:568
  22. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
    Authors: Alpár Et al.
    J Neurosci 2014;5:4421
  23. Presynaptic calcium channel inhibition underlies CB1 cannabinoid receptor-mediated suppression of GABA release.
    Authors: Szabó Et al.
    Mediators Inflamm 2014;34:7958
  24. Miswiring the brain: △9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.
    Authors: Tortoriello Et al.
    Proc Natl Acad Sci U S A 2014;33:668
  25. CB1 cannabinoid receptors are involved in neuroleptic-induced enhancement of brain neurotensin.
    Authors: Hassanzadeh and Rostami
    J Neurosci 2014;17:181
  26. Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
    Authors: Benz Et al.
    PLoS One 2013;8:e81675
  27. Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH.
    Authors: Chanda Et al.
    PLoS One 2013;8:e68845
  28. Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
    Authors: Cao Et al.
    PLoS One 2013;7:e52921
  29. The cannabinoid δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.
    Authors: Wargent Et al.
    Nutr Diabetes 2013;3:e68
  30. Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling.
    Authors: Keimpema Et al.
    Nat Commun 2013;3:2093
  31. Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory.
    Authors: Abush and Akirav
    Neuropsychopharmacology 2013;38:1521
  32. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
    Authors: Malenczyk Et al.
    J Biol Chem 2013;288:32685
  33. The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
    Authors: Sreevalsan and Safe
    Mol Cancer Ther 2013;12:2483
  34. Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
    Authors: Guida Et al.
    Mol Pain 2012;8:60
  35. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.
    Authors: Brents Et al.
    Biochem Pharmacol 2012;83:952
  36. CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation.
    Authors: Laricchiuta Et al.
    PLoS One 2012;7:e42111
  37. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
    Authors: Tozzi Et al.
    PLoS One 2012;7:e38312
  38. Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
    Authors: Casarotto Et al.
    Pain 2012;37:478
  39. Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.
    Authors: Ganon-Elazar and Akirav
    Neuropsychopharmacology 2012;37:456
  40. On disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment.
    Authors: Stern Et al.
    Neuropsychopharmacology 2012;37:2132
  41. Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.
    Authors: Gonzalez-Islas Et al.
    Sci Rep 2012;32:13597
  42. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep 2012;2:285
  43. Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene.
    Authors: Chanda Et al.
    Br J Pharmacol 2012;287:38041
  44. Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
    Authors: Tumati Et al.
    J Neuroimmunol 2012;244:23
  45. Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
    Authors: Niu Et al.
    J Pharmacol Exp Ther 2012;153:2283
  46. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
    Authors: Liu Et al.
    Mol Cancer Ther 2012;11:1421
  47. Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.
    Authors: Brents Et al.
    PLoS One 2011;6:e21917
  48. Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade.
    Authors: Crespillo Et al.
    Biochem J 2011;433:175
  49. Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice.
    Authors: Pan Et al.
    J Cell Biol 2011;31:13420
  50. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem 2011;18:545
  51. The Role of the Endocannabinoids in Suppression of the Hypothalamic-pituitary-adrenal Axis Activity by Doxepin.
    Authors: Hassanzadeh and Hassanzadeh
    J Leukoc Biol 2011;14:414
  52. The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period.
    Authors: Jiang Et al.
    Neuron 2010;66:248
  53. The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages.
    Authors: Hao Et al.
    Iran J Basic Med Sci 2010;51:2181
  54. Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
    Authors: Jones Et al.
    Cereb Cortex 2010;332:569
  55. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci 2010;32:1
  56. Cannabinoids excite circadian clock neurons.
    Authors: Acuna-Goycolea Et al.
    J Neurosci 2010;30:10061
  57. Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.
    Authors: Bhaskaran and Smith
    Endocrinology 2010;223:529
  58. Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
    Authors: Mair Et al.
    Br J Pharmacol 2010;161:176
  59. Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.
    Authors: Ho Et al.
    Neuropsychopharmacology 2010;160:736
  60. GPR55 ligands promote receptor coupling to multiple signalling pathways.
    Authors: Henstridge Et al.
    Br J Pharmacol 2010;160:604
  61. Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain.
    Authors: Curto-Reyes Et al.
    Br J Pharmacol 2010;160:561
  62. Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons.
    Authors: Farkas Et al.
    J Biol Chem 2010;151:5818
  63. Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic.
    Authors: Atkinson Et al.
    Endocrinology 2010;151:3720
  64. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.
    Authors: Schlosburg Et al.
    Nat Neurosci 2010;13:1113
  65. Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
    Authors: Yuan and Burrell
    J Neurophysiol 2010;104:2766
  66. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
    Authors: Garzón Et al.
    Mol Pain 2009;5:11
  67. PKCε regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2.
    Authors: Wallace Et al.
    Iran J Basic Med Sci 2009;34:1733
  68. The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice.
    Authors: Meuth Et al.
    Exp Neurol 2009;33:42675
  69. Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
    Authors: Mendiguren and Pineda
    Br J Pharmacol 2009;158:1579
  70. Endogenous cannabinoids induce fever through the activation of CB1 receptors.
    Authors: Fraga Et al.
    Neuropsychopharmacology 2009;157:1494
  71. Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
    Authors: Ho and Gardiner
    Br J Pharmacol 2009;156:94
  72. Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
    Authors: Tjen-A-Looi Et al.
    J Appl Physiol (1985) 2009;106:1793
  73. Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes.
    Authors: Börner Et al.
    Eur J Pharmacol 2008;73:1013
  74. Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.
    Authors: Georgieva Et al.
    Br J Pharmacol 2008;581:19
  75. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
    Authors: Gibson Et al.
    Neuron 2008;57:746
  76. Dichotomous dopaminergic control of striatal synaptic plasticity.
    Authors: Shen Et al.
    Science 2008;321:848
  77. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
    Authors: Melis Et al.
    J Neurosci 2008;28:13985
  78. Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
    Authors: Desroches Et al.
    Eur J Neurosci 2008;155:913
  79. Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.
    Authors: Giannini Et al.
    Br J Pharmacol 2008;12:2381
  80. The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms.
    Authors: Potenzieri Et al.
    Brain Res 2008;1215:69
  81. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis.
    Authors: Rajesh Et al.
    Cardiovasc Res 2007;82:1382
  82. The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
    Authors: Saitoh Et al.
    J Neurosci 2007;570:182
  83. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
    Authors: Kelm Et al.
    PLoS One 2007;323:356
  84. Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.
    Authors: Bátkai Et al.
    Br J Pharmacol 2007;293:H1689
  85. Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal.
    Authors: Huang Et al.
    J Neurosci 2007;27:4870
  86. Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons.
    Authors: Fortin and Levine
    J Biol Chem 2007;17:163
  87. Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats.
    Authors: Ghasemi Et al.
    EMBO J 2007;151:591
  88. Cannabinoid action in the olfactory epithelium.
    Authors: Czesnik Et al.
    Proc Natl Acad Sci U S A 2007;104:2967
  89. Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex.
    Authors: Crozier Et al.
    Proc Natl Acad Sci U S A 2007;104:1383
  90. Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
    Authors: Wang Et al.
    Neuron 2006;50:443
  91. Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils.
    Authors: Kurihara Et al.
    Br J Pharmacol 2006;281:12908
  92. Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus.
    Authors: Derbenev Et al.
    PLoS One 2006;26:9666
  93. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci 2006;26:4166
  94. Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.
    Authors: Cenni Et al.
    Eur J Neurosci 2006;24:1633
  95. Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
    Authors: Moezi Et al.
    J Neurosci 2006;149:898
  96. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
    Authors: Jayamanne Et al.
    J Neurosci 2006;147:281
  97. Endocannabinoids control the induction of cerebellar LTD.
    Authors: Safo and Regehr
    Neuron 2005;48:647
  98. Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.
    Authors: Pacher Et al.
    J Lipid Res 2005;289:H533
  99. Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.
    Authors: Hoffman Et al.
    Am J Physiol Heart Circ Physiol 2005;22:2387
  100. Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats.
    Authors: Gaskari Et al.
    Sci Rep 2005;146:315
  101. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.
    Authors: Berghuis Et al.
    Neurobiol Dis 2005;102:19115
  102. Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.
    Authors: Jin Et al.
    Am J Physiol Heart Circ Physiol 2004;66:204
  103. Endocannabinoid-mediated metaplasticity in the hippocampus.
    Authors: Chevaleyre and Castillo
    Neuron 2004;43:871
  104. Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors.
    Authors: Galarreta Et al.
    J Pharmacol Exp Ther 2004;24:9770
  105. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.
    Authors: Harkany Et al.
    Circulation 2004;24:4978
  106. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci 2004;24:4530
  107. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
    Authors: Price Et al.
    Br J Pharmacol 2004;142:257
  108. Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors.
    Authors: Akerman Et al.
    Br J Pharmacol 2004;142:1354
  109. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
    Authors: Mathison Et al.
    Br J Pharmacol 2004;142:1247
  110. Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
    Authors: Bátkai Et al.
    Eur J Pharmacol 2004;110:1996
  111. The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen.
    Authors: Scorticati Et al.
    Mol Pharmacol 2004;101:11891
  112. The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
    Authors: Williams Et al.
    J Cell Mol Med 2003;160:481
  113. An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
    Authors: Savinainen Et al.
    Br J Pharmacol 2003;140:1451
  114. Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes.
    Authors: Savinainen Et al.
    Br J Pharmacol 2001;134:664
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