AM 251

Tocris Bioscience | Catalog # 1117

Potent CB1 antagonist; also GPR55 agonist
Tocris Bioscience

Key Product Details

Description

Potent CB1 antagonist; also GPR55 agonist
View all Cannabinoid R1/CB1 Antagonists »

Product Description

AM 251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors. Also potent GPR55 agonist (EC50 = 39 nM) and μ-opioid receptor antagonist (Ki = 251 nM).

Fluorescent Form also available.

Product Specifications for AM 251

Molecular Weight

555.24

Formula

C22H21Cl2IN4O

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

CAS Number

183232-66-8

PubChem ID

2125

InChI Key

BUZAJRPLUGXRAB-UHFFFAOYSA-N

SMILES

CC1=C(N(N=C1C(=O)NN1CCCCC1)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(I)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.52 100
Ethanol 13.88 25

Preparing Stock Solutions for AM 251

The following data is based on the product molecular weight 555.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.80 mL 9.01 mL 18.01 mL
5 mM 0.36 mL 1.80 mL 3.60 mL
10 mM 0.18 mL 0.90 mL 1.80 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 945 publications citing the usage of this product.

Product Documents for AM 251

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AM 251

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for AM 251 (1)

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  • CB1R antagonist AM251 (5 µM)
    Name: Kang Peng
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: auditory brainstem（MNTB）
    Verified Customer | Posted 09/18/2018
    bath application of the CB1R antagonist AM251 (5 µM)

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