Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Biological ActivityTorin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Liu et al.
Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.
Simioni et al.
Citations for Torin 2
The citations listed below are publications that use Tocris products. Selected citations for Torin 2 include:
27 Citations: Showing 1 - 10
HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum.
Authors: Fuqin Et al.
J Physiol 2022;600:4917-4938
mTORC1 and mTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells.
Authors: Rinat R Et al.
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.
Authors: Steven A Et al.
Nat Commun 2022;13:3181
Visual barcodes for clonal-multiplexing of live microscopy-based assays.
Authors: Varda Et al.
Nat Commun 2022;13:2725
Liquid culture system for efficient depletion of the endogenous nutrients in Arabidopsis seedlings.
Authors: Yan Et al.
STAR Protoc 2021;2:100922
Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3.
Authors: Sung Hoon Et al.
Int J Mol Sci 2021;22
Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells.
Authors: Selim Et al.
Int J Med Sci 2021;18:137-149
The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth.
Authors: Pankaj K Et al.
Curr Dev Nutr 2020;4:nzaa131
Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.
Authors: Amy C Et al.
Antiviral Res 2019;167:45-67
Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.
Authors: Ginzberg Et al.
Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL.
Authors: Feehan Et al.
Cell Signal 2018;52:35
Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
Authors: Harari Et al.
Arterioscler Thromb Vasc Biol 2018;38:2217
SYK kinase mediates brown fat differentiation and activation.
Authors: Lei Et al.
Nat Commun 2017;8:2115
Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
Authors: Soliman Et al.
Metabolomics (Los Angel) 2017;6
The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
Authors: Al-Ali Et al.
J Neurosci 2017;37:7079
Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Authors: Jennewein Et al.
PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
Authors: Yu Et al.
BMC Biochem 2015;6:7212
Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.
Authors: Markus A Et al.
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Authors: Toops Et al.
Nat Commun 2015;26:41640
Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
Authors: Hussain Et al.
Mol Med 2015;21:466
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
Mol Biol Cell 2014;88:13149
High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
Authors: Ahmed Et al.
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
Authors: Martin Et al.
Am J Physiol Endocrinol Metab 2014;306:E1397
Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
Authors: Zullo Et al.
Parallel measurement of dynamic changes in translation rates in single cells.
Authors: Han Et al.
Nat Methods 2014;11:86
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
Authors: Hwang Et al.
J Biol Chem 2013;288:32064
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