Torin 2

  ( 11 citations )    
Product Datasheet
Catalog Number:4248
Chemical Name:9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Product Details
Citations (11)
Reviews
Biological Activity
Potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.
Technical Data
  • M.Wt:
    432.4
  • Formula:
    C24H15F3N4O
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1223001-51-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Torin 2 include:

11 Citations: Showing 1 - 10
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  1. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
    Authors: Jennewein Et al.
    Oncotarget  2016;7:20016
  2. PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.
    Authors: Yu Et al.
    BMC Biochem  2015;6:7212
  3. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
    Authors: Toops Et al.
    Nat Commun  2015;26:41640
  4. Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer.
    Authors: Hussain Et al.
    Mol Med  2015;21:466
  5. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
    Authors: Brown Et al.
    Mol Biol Cell  2014;88:13149
  6. High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
    Authors: Ahmed Et al.
    Carcinogenesis  2014;35:1564
  7. mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
    Authors: Martin Et al.
    Am J Physiol Endocrinol Metab  2014;306:E1397
  8. Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
    Authors: Zullo Et al.
    Cell  2014;15:4
  9. Parallel measurement of dynamic changes in translation rates in single cells.
    Authors: Han Et al.
    Nat Methods  2014;11:86
  10. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    J Virol  2013;64:4361
  11. Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
    Authors: Hwang Et al.
    J Biol Chem  2013;288:32064
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