Torin 2

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Torin 2 | CAS No. 1223001-51-1 | mTOR Inhibitors
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Description: Potent and selective mTOR inhibitor

Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

Purity: ≥98%

Product Details
Citations (27)

Biological Activity

Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.

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Citations for Torin 2

The citations listed below are publications that use Tocris products. Selected citations for Torin 2 include:

27 Citations: Showing 1 - 10

  1. HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum.
    Authors: Fuqin Et al.
    J Physiol  2022;600:4917-4938
  2. mTORC1 and mTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells.
    Authors: Rinat R Et al.
    Nutrients  2022;14
  3. RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.
    Authors: Steven A Et al.
    Nat Commun  2022;13:3181
  4. Visual barcodes for clonal-multiplexing of live microscopy-based assays.
    Authors: Varda Et al.
    Nat Commun  2022;13:2725
  5. Liquid culture system for efficient depletion of the endogenous nutrients in Arabidopsis seedlings.
    Authors: Yan Et al.
    STAR Protoc  2021;2:100922
  6. Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3.
    Authors: Sung Hoon Et al.
    Int J Mol Sci  2021;22
  7. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells.
    Authors: Selim Et al.
    Int J Med Sci  2021;18:137-149
  8. The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth.
    Authors: Pankaj K Et al.
    Curr Dev Nutr  2020;4:nzaa131
  9. Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.
    Authors: Amy C Et al.
    Antiviral Res  2019;167:45-67
  10. Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.
    Authors: Ginzberg Et al.
    Elife  2018;7
  11. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL.
    Authors: Feehan Et al.
    Cell Signal  2018;52:35
  12. Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
    Authors: Harari Et al.
    Arterioscler Thromb Vasc Biol  2018;38:2217
  13. SYK kinase mediates brown fat differentiation and activation.
    Authors: Lei Et al.
    Nat Commun  2017;8:2115
  14. Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
    Authors: Soliman Et al.
    Metabolomics (Los Angel)  2017;6
  15. The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
    Authors: Al-Ali Et al.
    J Neurosci  2017;37:7079
  16. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
    Authors: Jennewein Et al.
    Oncotarget  2016;7:20016
  17. PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
    Authors: Yu Et al.
    BMC Biochem  2015;6:7212
  18. Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.
    Authors: Markus A Et al.
    Carcinogenesis  2015;36:487-97
  19. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
    Authors: Toops Et al.
    Nat Commun  2015;26:41640
  20. Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
    Authors: Hussain Et al.
    Mol Med  2015;21:466
  21. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
    Authors: Brown Et al.
    Mol Biol Cell  2014;88:13149
  22. High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
    Authors: Ahmed Et al.
    Carcinogenesis  2014;35:1564
  23. mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
    Authors: Martin Et al.
    Am J Physiol Endocrinol Metab  2014;306:E1397
  24. Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
    Authors: Zullo Et al.
    Cell  2014;15:4
  25. Parallel measurement of dynamic changes in translation rates in single cells.
    Authors: Han Et al.
    Nat Methods  2014;11:86
  26. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    J Virol  2013;64:4361
  27. Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
    Authors: Hwang Et al.
    J Biol Chem  2013;288:32064


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