Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Biological ActivityPotent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Liu et al.
Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.
Simioni et al.
Citations for Torin 2
The citations listed below are publications that use Tocris products. Selected citations for Torin 2 include:
16 Citations: Showing 1 - 10
Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.
Authors: Ginzberg Et al.
Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL.
Authors: Feehan Et al.
Cell Signal 2018;52:35
Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
Authors: Harari Et al.
Arterioscler Thromb Vasc Biol 2018;38:2217
Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
Authors: Soliman Et al.
Metabolomics (Los Angel) 2017;6
The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
Authors: Al-Ali Et al.
J Neurosci 2017;37:7079
Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Authors: Jennewein Et al.
PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
Authors: Yu Et al.
BMC Biochem 2015;6:7212
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Authors: Toops Et al.
Nat Commun 2015;26:41640
Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
Authors: Hussain Et al.
Mol Med 2015;21:466
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
Mol Biol Cell 2014;88:13149
High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
Authors: Ahmed Et al.
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
Authors: Martin Et al.
Am J Physiol Endocrinol Metab 2014;306:E1397
Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
Authors: Zullo Et al.
Parallel measurement of dynamic changes in translation rates in single cells.
Authors: Han Et al.
Nat Methods 2014;11:86
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
Authors: Hwang Et al.
J Biol Chem 2013;288:32064
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100 nM for 1 hour