Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Biological ActivityPotent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Liu et al.
Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.
Simioni et al.
Citations for Torin 2
The citations listed below are publications that use Tocris products. Selected citations for Torin 2 include:
16 Citations: Showing 1 - 10
Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.
Authors: Ginzberg Et al.
Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL.
Authors: Feehan Et al.
Cell Signal 2018;52:35
Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
Authors: Harari Et al.
Arterioscler Thromb Vasc Biol 2018;38:2217
Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
Authors: Soliman Et al.
Metabolomics (Los Angel) 2017;6
The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
Authors: Al-Ali Et al.
J Neurosci 2017;37:7079
Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Authors: Jennewein Et al.
PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
Authors: Yu Et al.
BMC Biochem 2015;6:7212
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Authors: Toops Et al.
Nat Commun 2015;26:41640
Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
Authors: Hussain Et al.
Mol Med 2015;21:466
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
Mol Biol Cell 2014;88:13149
High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
Authors: Ahmed Et al.
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
Authors: Martin Et al.
Am J Physiol Endocrinol Metab 2014;306:E1397
Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
Authors: Zullo Et al.
Parallel measurement of dynamic changes in translation rates in single cells.
Authors: Han Et al.
Nat Methods 2014;11:86
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.
Authors: Hwang Et al.
J Biol Chem 2013;288:32064
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