Torin 2

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Torin 2 | CAS No. 1223001-51-1 | mTOR Inhibitors
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Description: Potent and selective mTOR inhibitor

Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

Purity: ≥98%

Product Details
Citations (16)

Biological Activity

Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.

Product Datasheets

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Citations for Torin 2

The citations listed below are publications that use Tocris products. Selected citations for Torin 2 include:

16 Citations: Showing 1 - 10

  1. Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.
    Authors: Ginzberg Et al.
    Elife  2018;7
  2. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL.
    Authors: Feehan Et al.
    Cell Signal  2018;52:35
  3. Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.
    Authors: Harari Et al.
    Arterioscler Thromb Vasc Biol  2018;38:2217
  4. Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
    Authors: Soliman Et al.
    Metabolomics (Los Angel)  2017;6
  5. The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
    Authors: Al-Ali Et al.
    J Neurosci  2017;37:7079
  6. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
    Authors: Jennewein Et al.
    Oncotarget  2016;7:20016
  7. PI3K/mTORC2 regulates TGF-β/AVNsignalling by modulating Smad2/3 activity via linker phosphorylation.
    Authors: Yu Et al.
    BMC Biochem  2015;6:7212
  8. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
    Authors: Toops Et al.
    Nat Commun  2015;26:41640
  9. Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of cisp. in Epithelial Ovarian Cancer.
    Authors: Hussain Et al.
    Mol Med  2015;21:466
  10. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
    Authors: Brown Et al.
    Mol Biol Cell  2014;88:13149


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