TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody

Novus Biologicals | Catalog # NB100-93535

Novus Biologicals
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Key Product Details

Species Reactivity

Zebrafish

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all TR beta 1/NR1A2 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-DIGSAPIVNAPEGNKVD corresponding to internal region according to Uniprot Zebrafish NP_571415.1.

Epitope

C-DIGSAPIVNAPEGNKVD

Specificity

This antibody is not expected to cross-react to Thra.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody

Western Blot: TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody [NB100-93535]

Western Blot: TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody [NB100-93535]

Western Blot: TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody [NB100-93535] - Staining of Zebrafish adult Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

2 - 5 ug/ml
Application Notes
WB: Approx. 50 kDa band observed in Zebrafish adult heart lysates (calculated MW of 44.3 kDa band according to NP_571415.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TR beta 1/NR1A2

Thyroid Hormone Receptor beta is encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).

Long Name

Thyroid Hormone Receptor beta 1

Alternate Names

NR1A2, THRB, v-ErbA2

Entrez Gene IDs

7068 (Human)

Gene Symbol

THRB

UniProt

NP_571415.1 (Zebrafish)

Additional TR beta 1/NR1A2 Products

Product Documents for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody

Certificate of Analysis

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Product Specific Notices for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody

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