TRAF3IP1 Antibody

Novus Biologicals | Catalog # NBP2-14847

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Primate

Predicted:

Chimpanzee (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all TRAF3IP1 Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 390-440 from human TRAF3IP1 was used as the immunogen for this antibody.

Reactivity Notes

The TRAF3IP1 amino acid sequence used as immunogen for this antibody is 89% in Orangutan, and White-cheeked Gibbon.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRAF3IP1 Antibody

Immunohistochemistry-Paraffin: TRAF3IP1 Antibody [NBP2-14847]

Immunohistochemistry-Paraffin: TRAF3IP1 Antibody [NBP2-14847]

Immunohistochemistry-Paraffin: TRAF3IP1 Antibody [NBP2-14847] - analysis of TRAF3IP1. Human testis probed with TRAF3IP1 antibody at 5 ug/ml.

Applications for TRAF3IP1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAF3IP1

TRAF3IP1, or MIP-T3 functions as a down regulator of type I IFN responses, a critical component of the innate immune defense in viral infection (1, 2). TRAF3IP1 is involved in the suppression of IL-13 and is effected through IL-13 induction of STAT6 phosphorylation (1). TRAF3IP1 interacts and inhibits TRAF3 complex formation and subsequent downstream signaling molecules RIG-I, MDA5 RIG-I like innate immune receptor molecules, VISA and MAVS, a pathway which leads to IRF mediated IFN-g responses. Additionally TRAF3IP1 also interferes with the signaling through TBK1 and IKKe a common juncture between RLR and TLR signaling (3, 4). It is TRAF3 interaction and binding with MAVS and inhibition of this complex in RLR signaling pathways as well as TRAF3IP1 regulation of TLR signaling that highlight a potential new target for studying IFN responses and regulating them. Antibody to TRAF3IP1 provides a unique tool to further development of regulators of IFN production.

Alternate Names

DKFZP434F124, Interleukin-13 receptor alpha 1-binding protein 1, Microtubule-interacting protein associated with TRAF3, microtubule-interacting protein that associates with TRAF3, MIPT3interleukin 13 receptor alpha 1-binding protein-1, MIP-T3microtubule interacting protein that associates with TRAF3, TNF receptor-associated factor 3 interacting protein 1, TRAF3-interacting protein 1

Gene Symbol

TRAF3IP1

UniProt

Q8TDR0 (Human)

Additional TRAF3IP1 Products

Product Documents for TRAF3IP1 Antibody

Certificate of Analysis

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Product Specific Notices for TRAF3IP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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