TRPM7 Antibody

Novus Biologicals | Catalog # NB100-810

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Predicted:

Canine (100%), Human (100%), Porcine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
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Product Specifications

Immunogen

Peptide with sequence C-TKESESTNSVRLML, from the C Terminus of the protein sequence according to NP_060142.3; NP_001288141.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for TRPM7 Antibody

Immunohistochemistry-Paraffin: TRPM7 Antibody [NB100-810]

Immunohistochemistry-Paraffin: TRPM7 Antibody [NB100-810]

Immunohistochemistry-Paraffin: TRPM7 Antibody [NB100-810] - (4ug/ml) staining of paraffin embedded Mouse Hippocampus. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Similar results were obtained after antigen retrieval at pH9.

Applications for TRPM7 Antibody

Application
Recommended Usage

Immunohistochemistry

4 - 6 ug/ml

Immunohistochemistry-Paraffin

4 - 6 ug/ml

Peptide ELISA

Detection Limit 1:8000
Application Notes
IHC-P: Mouse brain shows neuronal staining in the hippocampus. IHC successful usage on rat hippocampus is reported in scientific literature (PMID: 19734892). The observed MW corresponds to earlier findings in scientific literature with different antibodies (PMID: 18365021).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TRPM7

The TRPM7 (Transient Receptor Protein-PhosphoLipase C-Interacting Kinase) protein is a member of the ion channel proteins. It regulates the calcium concentration in cells, which is imperative for such functions as muscle contractions and neuronal firing. TRPM7, however, is unique among the TRP channel proteins because it is bi-functional. It not only controls ion channels but it also acts as a kinase, phosphorylating proteins.

Alternate Names

CHAK, CHAK1FLJ25718, Channel-kinase 1, EC 2.7.11.1, Long transient receptor potential channel 7, LTRPC ion channel family member 7, LTrpC7, LTrpC-7, LTRPC7FLJ20117, transient receptor potential cation channel subfamily M member 7, transient receptor potential cation channel, subfamily M, member 7, transient receptor potential-phospholipase C-interacting kinase, TRP-PLIK

Entrez Gene IDs

54822 (Human)

Gene Symbol

TRPM7

UniProt

NP_060142.3 (Human), NP_001288141.1 (Human)

Additional TRPM7 Products

Product Documents for TRPM7 Antibody

Certificate of Analysis

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Product Specific Notices for TRPM7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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