TTF-1 / NKX2-1 Antibody (G21-G)

Novus Biologicals | Catalog # NBP1-79056

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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # G21-G
View all TTF-1/NKX2-1 Primary Antibodies »

Product Specifications

Immunogen

Peptide derived from N-terminal sequence of human TTF-1 / NKX2-1. Antibody recognizes the epitope between Leu97 - Gly110.

Epitope

Leu97 - Gly110

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

Scientific Data Images for TTF-1 / NKX2-1 Antibody (G21-G)

Immunohistochemistry-Paraffin: TTF-1 / NKX2-1 Antibody (G21-G) [NBP1-79056]

Immunohistochemistry-Paraffin: TTF-1 / NKX2-1 Antibody (G21-G) [NBP1-79056]

Immunohistochemistry-Paraffin: TTF1 / NKX2.1 Antibody (G21-G) [NBP1-79056] - Thyroid papillary carcinoma. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti-TTF1monospecific antibody.
Immunohistochemistry-Paraffin: TTF-1 / NKX2-1 Antibody (G21-G) [NBP1-79056]

Immunohistochemistry-Paraffin: TTF-1 / NKX2-1 Antibody (G21-G) [NBP1-79056]

Immunohistochemistry-Paraffin: TTF1 / NKX2.1 Antibody (G21-G) [NBP1-79056] - Nuclear expression of TTF1 in lung adenocarcinoma. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti-TTF1 monospecific antibody.
Immunohistochemistry-Paraffin: TTF-1 / NKX2-1 Antibody (G21-G) [NBP1-79056]

Immunohistochemistry-Paraffin: TTF-1 / NKX2-1 Antibody (G21-G) [NBP1-79056]

Immunohistochemistry-Paraffin: TTF1 / NKX2.1 Antibody (G21-G) [NBP1-79056] - Nuclear expression of TTF1 in lung adenocarcinoma. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti-TTF1 monospecific antibody.

Applications for TTF-1 / NKX2-1 Antibody (G21-G)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:100-1:200

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

20mM Tris-HCl (pH 8.0) and 20mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TTF-1/NKX2-1

The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype (1). Thyroid dysgenesis (TD) is responsible for most cases of congenital hypothyroidism, a condition that affects about one in 4000 newborns. Mutations in PAX8, TTF1, or FOXE1 may account for congenital hypothyroidism in patients with either isolated TD or TD with associated malformations involving kidney, lung, forebrain, and palate (2). In addition to its presence in thyroid gland epithelium, the human TTF-1 protein was detected by immunohistochemistry in human fetal lung as early as 11 weeks of gestation, being localized in the nuclei of epithelial cells of the developing airways. After birth, TTF-1 was selectively expressed in Type II epithelial cells in the alveoli and in subsets of bronchiolar epithelial cells in the conducting regions of the lung (3).

Long Name

NK2 Homeobox 1

Alternate Names

BCH, BHC, NKX2-1, NKX2.1, NKX2A, T/EBP, TITF1, TTF1

Gene Symbol

NKX2-1

Additional TTF-1/NKX2-1 Products

Product Documents for TTF-1 / NKX2-1 Antibody (G21-G)

Certificate of Analysis

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Product Specific Notices for TTF-1 / NKX2-1 Antibody (G21-G)

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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