TY 52156

Key Product Details

Product Description

TY 52156 is an S1P₃ receptor antagonist (K_i = 110 nM); inhibits S1P-induced Ca²⁺ release in HUVEC cells. Suppresses FTY-720-induced S1P₃ receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.

Product Specifications for TY 52156

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TY 52156

The following data is based on the product molecular weight 364.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.73 mL	27.45 mL
5 mM	0.55 mL	2.75 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.75 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

• Hirata Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR₃ by a ligand-independent Notch activation. Nat.Commun. 2014 PMID: 25254944
• Murakami Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P₃ receptor: investigation based on a new S1P₃ receptor antagonist. Mol.Pharmacol. 2010 PMID: 20097776

Product Documents for TY 52156