Chemical Name: N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
Biological ActivityTY 52156 is a S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist.
Murakami et al.
Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation.
Hirata et al.
Citations for TY 52156
The citations listed below are publications that use Tocris products. Selected citations for TY 52156 include:
5 Citations: Showing 1 - 5
Pro-Inflammatory Role of S1P3 in Macrophages.
Authors: Heo and Im
Biomol Ther (Seoul) 2019;
Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
Authors: H?bner Et al.
Nat Commun 2018;9:4860
A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.
Authors: Ma Et al.
Dev Cell 2017;41:366
Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model.
Authors: Schuhmann Et al.
J Neurosci 2015;16:29454
Fingolimod induces neuroprotective factors in human astrocytes.
Authors: Hoffmann Et al.
J Neuroinflammation 2015;12:184
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