Catalog Number: 5328
Chemical Name: N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
Biological Activity
S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.
Technical Data
  • M.Wt:
    364.27
  • Formula:
    C18H19Cl2N3O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    934369-14-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist.
    Murakami et al.
    Mol.Pharmacol., 2010;77:704
  2. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation.
    Hirata et al.
    Nat.Commun., 2014;25:4806
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TY 52156 include:

2 Citations: Showing 1 - 2
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  1. Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model.
    Authors: Schuhmann Et al.
    J Neurosci 2015;16:29454
  2. Fingolimod induces neuroprotective factors in human astrocytes.
    Authors: Hoffmann Et al.
    J Neuroinflammation 2015;12:184

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