Chemical Name:N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
Biological Activity S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C
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