UACA Antibody

Novus Biologicals | Catalog # NB100-61623

Novus Biologicals
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Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all UACA Primary Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 1075 and 1125 of human uveal autoantigen with coiled-coil domains and ankyrin repeats using the numbering given in entry NP_060473.2 (GeneID 55075).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UACA Antibody

Western Blot: UACA Antibody [NB100-61623]

Western Blot: UACA Antibody [NB100-61623]

Western Blot: UACA Antibody [NB100-61623] - Detection of Mouse and Rat UACA by Western Blot. Samples: Whole cell lysate (50 ug) from NIH3T3, TCMK-1, 4T1, CT26.WT, and rat C6 cells. Antibodies: Affinity purified rabbit anti-UACA antibody was used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Western Blot: UACA Antibody [NB100-61623]

Western Blot: UACA Antibody [NB100-61623]

Western Blot: UACA Antibody [NB100-61623] - Detection of Human UACAon HeLa whole cell lysate using NB100-61623. UACA was also immunoprecipitated by rabbit anti-UACA antibodies NB100-61621 and NB100-61622.

Applications for UACA Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: UACA

UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

Alternate Names

FLJ10128, KIAA1561MGC141969, MGC141967, nuclear membrane binding protein, NUCLING, uveal autoantigen with coiled coil domains and ankyrin repeats, uveal autoantigen with coiled-coil domains and ankyrin repeats

Entrez Gene IDs

55075 (Human)

Gene Symbol

UACA

UniProt

Q9BZF9 (Human)

Additional UACA Products

Product Documents for UACA Antibody

Certificate of Analysis

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Product Specific Notices for UACA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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