Universal Type I IFN Protein

(Recombinant Human IFN-alpha A/D [BglII])
Catalog # Availability Size / Price Qty
11200-1
Product Details
Citations (19)
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Universal Type I IFN Protein Summary

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Background: IFN-alpha

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Long Name
Interferon alpha
Entrez Gene IDs
3440 (Human)
Alternate Names
IFNA; IFNA2; IFNA2b; IFNalpha; IFN-alpha; IFN-alphaA; INFA2; interferon alpha 2

Citations for Universal Type I IFN Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

19 Citations: Showing 1 - 10
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  1. Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
    Authors: U Cytlak, A Resteu, D Bogaert, HS Kuehn, T Altmann, A Gennery, G Jackson, A Kumanovics, KV Voelkerdin, S Prader, M Dullaers, J Reichenbac, H Hill, F Haerynck, SD Rosenzweig, M Collin, V Bigley
    Nat Commun, 2018;9(1):1239.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus
    Authors: K Matsuno, M Kajihara, R Nakao, N Nao, A Mori-Kajih, M Muramatsu, Y Qiu, S Torii, M Igarashi, N Kasajima, K Mizuma, K Yoshii, H Sawa, C Sugimoto, A Takada, H Ebihara
    mSphere, 2018;3(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. IL-15 and IFN-? signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling
    Authors: F Vahedi, AJ Lee, SE Collins, MV Chew, E Lusty, B Chen, A Dubey, CD Richards, JJ Feld, RS Russell, KL Mossman, AA Ashkar
    Cytokine, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL)-1? and IL-18 release
    Authors: X Dai, M Tohyama, M Murakami, K Sayama
    Exp. Dermatol, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
    Nature, 2016;533(7604):493-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Type I IFN counters or promotes Coxiella burnetii replication dependent on tissue
    Authors: JF Hedges, A Robison, E Kimmel, K Christense, E Lucas, A Ramstead, MA Jutila
    Infect Immun, 2016;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  7. ATF3 Is a Key Regulator of Macrophage IFN Responses.
    Authors: Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D
    J Immunol, 2015;195(9):4446-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness.
    Authors: Li X, Jiang L, Chen L, Ding M, Guo H, Zhang W, Zhang H, Ma X, Liu X, Xi X, Chen S, Chen Z, Zhu J
    Mol Cell, 2014;53(3):407-19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.
    Authors: Wang T, Ge Y, Xiao M, Lopez-Coral A, Li L, Roesch A, Huang C, Alexander P, Vogt T, Xu X, Hwang W, Lieu M, Belser E, Liu R, Somasundaram R, Herlyn M, Kaufman R
    J Invest Dermatol, 2014;134(4):1108-18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. An innate immunity-regulating virulence determinant is uniquely encoded by the Andes virus nucleocapsid protein.
    Authors: Cimica V, Dalrymple N, Roth E, Nasonov A, Mackow E
    MBio, 2014;5(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Annexin V incorporated into influenza virus particles inhibits gamma interferon signaling and promotes viral replication.
    Authors: Berri F, Haffar G, Le V, Sadewasser A, Paki K, Lina B, Wolff T, Riteau B
    J Virol, 2014;88(19):11215-28.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.
    Authors: Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H
    PLoS ONE, 2013;8(12):e82586.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
    Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
    Clin Cancer Res, 2013;19(7):1858-72.
    Species: Human
    Sample Types:
  14. BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1).
    Authors: Jones P, Maric M, Madison M, Maury W, Roller R, Okeoma C
    Virology, 2013;438(1):37-49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus.
    Authors: Webster, Brian, Ott, Melanie, Greene, Warner C
    J Virol, 2013;87(24):13354-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival.
    Authors: Cilloniz C, Pantin-Jackwood MJ, Ni C, Carter VS, Korth MJ, Swayne DE, Tumpey TM, Katze MG
    J. Virol., 2012;86(5):2437-46.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  18. Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma.
    Authors: Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C
    PLoS Pathog., 2011;7(4):e1002016.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
    Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
    J. Exp. Med., 2009;206(1):249-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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