Uroplakin IIIB Antibody (DBRRM3.66)

Novus Biologicals | Catalog # NBP3-45117

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Kappa Clone # DBRRM3.66
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Product Specifications

Immunogen

Recombinant human Uroplakin 3B protein fragment (around aa 100-300)

Specificity

Uroplakin 3B is expressed on the surface of urothelial epithelial and mesothelial. Its antibody is very useful in identifying urothelial and mesothelial origin of cancers by immunohistochemistry. This protein encoded by this gene is a member of transmembrane 4 superfamily. The protein mediate signal transduction events that play a role in the regulation of cell development, activation.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Scientific Data Images for Uroplakin IIIB Antibody (DBRRM3.66)

Uroplakin IIIB Antibody (DBRRM3.66)

Immunohistochemistry-Paraffin: Rabbit Uroplakin IIIB mAb (DBRRM3.66) [NBP3-45117]

Formalin fixed paraffin embedded human urothelial carcinoma tissue stained with Uroplakin 3B

Applications for Uroplakin IIIB Antibody (DBRRM3.66)

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4), Tween-20, 0.2% BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Uroplakin IIIB

UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM]

Alternate Names

FLJ32198, MGC10902, p35, UP3b, UPIIIB, UPIIIbP35, uroplakin 3B, Uroplakin IIIb, uroplakin-3b

Gene Symbol

UPK3B

Additional Uroplakin IIIB Products

Product Documents for Uroplakin IIIB Antibody (DBRRM3.66)

Certificate of Analysis

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Product Specific Notices for Uroplakin IIIB Antibody (DBRRM3.66)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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