Vanilloid R1/TRPV1 Antibody

Novus Biologicals | Catalog # NB100-98886

Novus Biologicals
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunocytochemistry/ Immunofluorescence

Cited:

Immunohistochemistry, Western Blot, Immunocytochemistry/ Immunofluorescence, IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all Vanilloid R1/TRPV1 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide from the 1t cytoplasmic loop of human Vanilloid R1/TRPV1 conjugated to blue carrier protein was used as the antigen.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 21515789).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Vanilloid R1/TRPV1 Antibody

Western Blot: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Western Blot: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Vanilloid-R1-TRPV1-Antibody-Western-Blot-NB100-98886-img0009.jpg
Immunocytochemistry/ Immunofluorescence: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunocytochemistry/ Immunofluorescence: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Vanilloid-R1-TRPV1-Antibody-Immunocytochemistry-Immunofluorescence-NB100-98886-img0010.jpg
Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886] - Human hippocampus. HIER: Tris-EDTA, pH 9 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um
Western Blot: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Western Blot: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Vanilloid-R1-TRPV1-Antibody-Western-Blot-NB100-98886-img0008.jpg
Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886] - Human hippocampus. HIER: Tris-EDTA, pH 9 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um.
Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886] - Human hippocampus. HIER: Tris-EDTA, pH 9 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um
Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886] - Human hippocampus. HIER: Tris-EDTA, pH 9 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um
Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886] - Human hippocampus. HIER: Tris-EDTA, pH 9 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um
Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98886] - Human hippocampus. HIER: Tris-EDTA, pH 9 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um

Applications for Vanilloid R1/TRPV1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10-1:500

Immunohistochemistry

1:1000

Immunohistochemistry-Paraffin

1:1000

Western Blot

1:1000
Application Notes
IHC reported in scientific literature (PMID: 31680864). ICC/IF reported in scientific literature (PMID: 21515789).

Formulation, Preparation, and Storage

Purification

Unpurified

Reconstitution

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the sample size is provided in reconstituted format.

Formulation

Lyophilized from whole antisera

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Vanilloid R1/TRPV1

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. FUNCTION: Receptor-activated non-selective calcium permanent cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.

Long Name

Vanilloid Receptor 1/Transient Receptor Potential Cation Channel 1

Alternate Names

Capsaicin Receptor, TRPV1, VanilloidR1, VR1

Entrez Gene IDs

7442 (Human)

Gene Symbol

TRPV1

UniProt

Q8NER1 (Human)

Additional Vanilloid R1/TRPV1 Products

Product Documents for Vanilloid R1/TRPV1 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Vanilloid R1/TRPV1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Vanilloid R1/TRPV1 Antibody

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Protocols

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