Vanilloid R1/TRPV1 Antibody [Biotin]

Novus Biologicals | Catalog # NBP1-97417B

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Invertebrate, Primate

Applications

Western Blot, Immunofluorescence, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Negative)

Label

Biotin

Antibody Source

Polyclonal Rabbit IgG
View all Vanilloid R1/TRPV1 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to an N-terminal portion of the rat TRPV1 protein (between residues 1-50) [Uniprot: O35433]

Reactivity Notes

Reactive to Octopus vulgaris.

Localization

Multi-pass membrane protein. Note: Mostly, but not exclusively expressed in post-synaptic dendritic spines.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Vanilloid R1/TRPV1 Antibody [Biotin]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry (Negative)

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Vanilloid R1/TRPV1

TRPV1 (transient receptor potential cation channel subfamily V member 1, capsaicin receptor, vanilloid receptor, Vr1) is a polymodal nociceptor activated by heat, vanilloids (capsaicin), and protons. It is primarily expressed in the dorsal root ganglia and peripheral nerve endings. TRPV1 antagonists are a potential therapeutic target for many suffering chronic physical and neuropathic pain. However, due to its other role in the regulation of body temperature, these therapies are currently experiencing a barrier. On the other hand, TRPV1 agonists can be used to desensitize nerves after activation, thereby reducing pain. The research around TRPV1 is broad, where it is studied in fields such as anxiety, pain, oxidative stress, taste, inflammation, depression, respiratory disease, and various psychiatric disorders.

Long Name

Vanilloid Receptor 1/Transient Receptor Potential Cation Channel 1

Alternate Names

Capsaicin Receptor, TRPV1, VanilloidR1, VR1

Gene Symbol

TRPV1

Additional Vanilloid R1/TRPV1 Products

Product Documents for Vanilloid R1/TRPV1 Antibody [Biotin]

Certificate of Analysis

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Product Specific Notices for Vanilloid R1/TRPV1 Antibody [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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