VE-Cadherin Antibody (BV13) [Biotin]

Name: VE-Cadherin Antibody (BV13) [Biotin]
Brand: Novus Biologicals
SKU: NBP1-43579
Price: 249 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-43579

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Product Specifications
Scientific Data
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot, Flow Cytometry

Label

Biotin

Antibody Source

Monoclonal Rat IgG₁ Clone # BV13

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Product Specifications

Immunogen

The immunogen for this antibody was CD144.

Marker

Endothelial Cell Marker

Clonality

Monoclonal

Host

Rat

Isotype

IgG₁

Scientific Data Images for VE-Cadherin Antibody (BV13) [Biotin]

Flow Cytometry: VE-Cadherin Antibody (BV13) [Biotin] [NBP1-43579] - Staining of bEnd.3 cell line with 0.5 micrograms of Rat IgG1 k Isotype Control Biotin (blue histogram) or 0.125 micrograms of Anti-Mouse CD144 (VE-Cadherin) Biotin purple histogram) followed by Streptavidin PE. Total viable cells were used for analysis.

Applications for VE-Cadherin Antibody (BV13) [Biotin]

Application

Recommended Usage

Flow Cytometry

1:10-1:1000

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Western Blot

1:100-1:2000

Application Notes

Intravenous injection of BV13 has been shown to induce a concentration- and timedependent increase in vascular permeability in the heart and lungs.

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Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS (pH 7.2) with 0.1% gelatin

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: VE-Cadherin

The BV13 monoclonal antibody reacts with mouse VE-Cadherin (CD144). VE-Cadherin is a 120 kDa member of the type II Cadherin family, characterized by the presence of 5 extracellular cadherin domains (ECD), and anchored to the actin cytoskeleton through their cytoplasmic tail. VE-Cadherin mediates homophilic adhesion between neighbouring endothelial cells and is localized within specialized structures at cell-cell contacts, called adherens junctions. VE-Cadherin is expressed constitutively throughout the entire vasculature, and is required for numerous endothelial cell functions including migration, survival, contact-dependent growth inhibition and endothelial cell assembly into tubular structures. Furthermore, it is thought that VE-Cadherin+CD45- cells from the yolk sac or aorta-gonad-mesonephros (AGM) have the potential to give rise to hematopoietic cells.

Long Name

Vascular Endothelium Cadherin

Alternate Names

Cadherin-5, CD144, CDH5, VECadherin

Gene Symbol

CDH5

Additional VE-Cadherin Products

Product Documents for VE-Cadherin Antibody (BV13) [Biotin]

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Certificate of Analysis

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Product Specific Notices for VE-Cadherin Antibody (BV13) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.