Chemical Name: 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide
Biological ActivitySphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Sphingosine-1-phosphate analogs as receptor antagonists.
Davis et al.
The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3.
Aoki et al.
High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL.
Mihovilovic et al.
J.Lipid Res., 2007;48:806
Citations for VPC 23019
The citations listed below are publications that use Tocris products. Selected citations for VPC 23019 include:
3 Citations: Showing 1 - 3
Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy.
Authors: Willems Et al.
Evid Based Complement Alternat Med 2016;4:28
Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells
Authors: Wirrig Et al.
Biochemical Pharmacology 2016;115:43
Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.
Authors: Miller Et al.
Mol Cell Biol 2008;28:4142
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