Chemical Name: 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide
Biological ActivityVPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Sphingosine-1-phosphate analogs as receptor antagonists.
Davis et al.
The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3.
Aoki et al.
High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL.
Mihovilovic et al.
J.Lipid Res., 2007;48:806
Citations for VPC 23019
The citations listed below are publications that use Tocris products. Selected citations for VPC 23019 include:
8 Citations: Showing 1 - 8
Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease.
Authors: Jolene J Et al.
J Cell Biochem 2021;122:335-348
Neonatal HDL Counteracts Placental Vascular Inflammation via S1P-S1PR1 Axis.
Authors: Christian Et al.
Int J Mol Sci 2020;21
Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature.
Authors: Eva Et al.
Biochim Biophys Acta Mol Cell Biol Lipids 2020;1865:158632
Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse.
Authors: Greig Et al.
Eur J Pharmacol 2019;842:1
Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation.
Authors: Sharma Et al.
Sci Rep 2018;8:6618
Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy.
Authors: Willems Et al.
Evid Based Complement Alternat Med 2016;4:28
Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells
Authors: Wirrig Et al.
Biochemical Pharmacology 2016;115:43
Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.
Authors: Miller Et al.
Mol Cell Biol 2008;28:4142
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