Home / Group I mGluR Modulators / VU 0285683

VU 0285683

4381 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4381/10
4381/50
Group I mGluR Modulators Small Molecule
1 Image
Description: Negative allosteric modulator of mGlu5 receptors

Chemical Name: 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile

Purity: ≥98%

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Biological Activity

Negative allosteric modulator of mGlu5 receptors. Displays high affinity for the MPEP (Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu5 (IC50 = 24.4 nM). Selective for mGlu5 over mGlu1, mGlu3 and mGlu4. Exhibits anxiolytic activity in rodent models of anxiety. Analog available (Cat. No. 4323).

Technical Data

M.Wt:
266.23
Formula:
C14H7FN4O
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
327056-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VersaClone cDNA Plasmids

Human mGluR5 (NP_000833) VersaClone cDNA

RDC1064

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