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VU 0285683

4381 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4381/10
4381/50
Cat.No. 4381 - VU 0285683 | C14H7FN4O | CAS No. 327056-22-4
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Description: Negative allosteric modulator at mGlu5

Chemical Name: 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile

Purity: ≥98%

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Biological Activity

Negative allosteric modulator of mGlu5 receptors. Displays high affinity for the MPEP (Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu5 (IC50 = 24.4 nM). Selective for mGlu5 over mGlu1, mGlu3 and mGlu4. Exhibits anxiolytic activity in rodent models of anxiety. Analog available (Cat. No. 4323).

Technical Data

M.Wt:
266.23
Formula:
C14H7FN4O
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
327056-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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VersaClone cDNA Plasmids

Human mGluR5 (NP_000833) VersaClone cDNA

RDC1064

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