Negative allosteric modulator of mGlu5
receptors. Displays high affinity for the MPEP
(Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu5
= 24.4 nM). Selective for mGlu5
. Exhibits anxiolytic activity in rodent models of anxiety. Analog
available (Cat. No. 4323).
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All Tocris products are intended for laboratory research use only.
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.