WYE 687 dihydrochloride

Catalog # Availability Size / Price Qty
4282/10
4282/50
WYE 687 dihydrochloride | CAS No. 1702364-87-1 | mTOR Inhibitors
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Description: Potent and selective mTOR inhibitor

Chemical Name: N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7 nM). Displays selectivity for mTOR over PI 3-Kα (~100-fold) and PI 3-Kγ (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1α expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis.

Technical Data

M.Wt:
601.53
Formula:
C28H32N8O32HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1702364-87-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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Citation for WYE 687 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for WYE 687 dihydrochloride include:

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