xStAx-VHLL

Catalog # Availability Size / Price Qty
7298/100U
xStAx-VHLL
1 Image
Description: Selective peptide-based β-catenin Degrader (PROTAC®)

Purity: ≥95%

Product Details
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Biological Activity

xStAx-VHLL is a selective peptide-based β-catenin Degrader (PROTAC®). Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids. β-catenin antibodies validated for Simple Western™ (automated Western Blot) instruments and Western Blot also available: Catalog # AF1329 and NBP1-54467.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
3231.89
Formula:
C154H244N48O29
Sequence:
RRWPRXILDXHVRRVWRALAPYIP

(Modifications: Arg-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-6 and X-10 stapled together with a double bond, Arg-17 = Arg-Ahx, Pro-24 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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