xStAx-VHLL

Tocris Bioscience | Catalog # 7298

Selective peptide-based β-catenin Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Selective peptide-based β-catenin Degrader (PROTAC®)
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Product Description

xStAx-VHLL is a selective peptide-based β-catenin Degrader (PROTAC®). Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.

β-catenin antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF1329 and NBP1-54467.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for xStAx-VHLL

Molecular Weight

3231.89

Formula

C154H244N48O29

Storage

Store at -20°C

Purity

≥95% (HPLC)

InChI Key

IAIGOXKADOABIF-BDNJFVESSA-N

SMILES

O=C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@](C)(C(N[C@H](C(N[C@H](C(N[C@H]2CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC/C=C\CCC[C@@](C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@@H](CCC3)C(N[C@H](C(N[C@H](C(N4[C@@H](CCC4)C(N)=O)=O)[C@H](CC)C)=O)CC5=CC=C(O)C=C5)=O)=O)C)=O)CC(C)C)=O)C)=O)=O)CCCNC(N)=N)=O)CC6=CNC7=C6C=CC=C7)=O)C(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C)C)=O)CC8=CN=CN8)=O)NC2=O)=O)CCCNC(N)=N)=O)=O)CC9=CNC%10=C9C=CC=C%10)=O)CCCNC(N)=N)[C@@H](NC(C)=O)CCCNC(N)=N.O=C(N[C@H](C(N[C@H](C(N%11CCC[C@H]%11C(N[C@H](C(N[C@](C)(C(N[C@H](C(N[C@H](C(N[C@H]%12CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC/C=C/CCC[C@@](C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N%13[C@@H](CCC%13)C(N[C@H](C(N[C@H](C(N%14[C@@H](CCC%14)C(N)=O)=O)[C@H](CC)C)=O)CC%15=CC=C(O)C=C%15)=O)=O)C)=O)CC(C)C)=O)C)=O)=O)CCCNC(N)=N)=O)CC%16=CNC%17=C%16C=CC=C%17)=O)C(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C)C)=O)CC%18=CN=CN%18)=O)NC%12=O)=O)CCCNC(N)=N)=O)=O)CC%19=CNC%20=C%19C=CC=C%20)=O)CCCNC(N)=N)[C@@H](NC(C)=O)CCCNC(N)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for xStAx-VHLL

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for xStAx-VHLL

For research use only

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