ZCCHC11/TUT4 Antibody

Name: ZCCHC11/TUT4 Antibody
Brand: Novus Biologicals
SKU: NBP1-42654
Price: 459 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-42654

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

Western Blot, Immunoprecipitation (Negative)

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

View all ZCCHC11/TUT4 Primary Antibodies »

Product Specifications

Immunogen

The immunogen for this product maps to a region between residue 1 and 50 of human zinc finger, CCHC domain containing 11 (NP_056084.1).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ZCCHC11/TUT4 Antibody

Western Blot: ZCCHC11/TUT4 Antibody [NBP1-42654]

Western Blot: ZCCHC11/TUT4 Antibody [NBP1-42654] - Whole cell lysate from HeLa (5, 15 and 50 ug) and 293T (T; 50 ug) cells. Antibody used at 0.04 ug/ml.

Applications for ZCCHC11/TUT4 Antibody

Application

Recommended Usage

Western Blot

1:2000-1:10000

Application Notes

Immunoprecipitation Not recommended

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: ZCCHC11/TUT4

Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28 and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation

Alternate Names

DKFZp779C1943, EC 2.7.7.52, KIAA0191FLJ42878, PAP associated domain containing 3, PAPD3, terminal uridylyltransferase 4, TUT4, TUTase 4, Zinc finger CCHC domain-containing protein 11, zinc finger, CCHC domain containing 11

Entrez Gene IDs

23318 (Human)

Gene Symbol

TUT4

UniProt

Q5TAX3 (Human)

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Product Documents for ZCCHC11/TUT4 Antibody

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Product Specific Notices for ZCCHC11/TUT4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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