Adaptor Proteins in the Akt Pathway
Adaptor proteins are essential molecules that influence signal transduction pathways, governing cross-talk and specificity. They contain protein-binding motifs that facilitate interactions between protein-binding partners and the generation of larger signaling complexes. Many adaptor proteins are required to link molecules via protein interactions within a signal transduction cascade to ensure the appropriate signaling response. The adaptor proteins listed below have been associated with activation of the Akt signaling pathway. This signaling pathway promotes cell growth, survival, and proliferation, regulates autophagy, and plays an important role in metabolism.