Adenosine A3 Receptors

Adenosine A3 Receptor (ADORA3) belongs to the family of adenosine receptors, which are G protein-coupled receptors involved in a variety of intracellular signaling pathways and physiological functions. ADORA3 mediates a sustained cardioprotective function during cardiac ischemia. It is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. ADORA3 has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death.